Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Miriam, Alb"'
Autor:
Bettina Glatte, Kerstin Wenk, Anja Grahnert, Maik Friedrich, Maximilian Merz, Vladan Vucinic, Luise Fischer, Kristin Reiche, Miriam Alb, Michael Hudecek, Paul Franz, Stephan Fricke, Uwe Platzbecker, Ulrike Koehl, Ulrich Sack, Andreas Boldt, Sunna Hauschildt, Ronald Weiss
Publikováno v:
Blood Advances.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6878a46a78390c69e3743ce7afbf4a41
https://doi.org/10.1182/bloodadvances.2023009714
https://doi.org/10.1182/bloodadvances.2023009714
Autor:
Alexander Mazein, Muhammad Shoaib, Miriam Alb, Christina Sakellariou, Charline Sommer, Katherina Sewald, Kristin Reiche, Patricia Gogesch, Luise A Roser, Samira Ortega Iannazzo, Sapna Sheth, Susanne Schiffmann, Zoe Waibler, Vanessa Neuhaus, Susann Dehmel, Venkata Satagopam, Reinhard Schneider, Marek Ostaszewski, Wei Gu
We address the need for modelling and predicting adverse outcomes in immunotoxicology to improve non-clinical assessments of immunomodulatory therapy safety and efficacy. The integrated approach includes, first, the adverse outcome pathway concept es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a120503547f80780247e0a3025525e0a
https://doi.org/10.1101/2023.03.21.533620
https://doi.org/10.1101/2023.03.21.533620
Autor:
Emmanuel Donnadieu, Maik Luu, Miriam Alb, Brigitte Anliker, Silvia Arcangeli, Chiara Bonini, Biagio De Angelis, Rashmi Choudhary, David Espie, Anne Galy, Cam Holland, Zoltán Ivics, Chahrazade Kantari-Mimoun, Marie Jose Kersten, Ulrike Köhl, Chantal Kuhn, Bruno Laugel, Franco Locatelli, Ibtissam Marchiq, Janet Markman, Marta Angiola Moresco, Emma Morris, Helene Negre, Concetta Quintarelli, Michael Rade, Kristin Reiche, Matthias Renner, Eliana Ruggiero, Carmen Sanges, Hans Stauss, Maria Themeli, Jan Van den Brulle, Michael Hudecek, Monica Casucci
Publikováno v:
Donnadieu, E, Luu, M, Alb, M, Anliker, B, Arcangeli, S, Bonini, C, de Angelis, B, Choudhary, R, Espie, D, Galy, A, Holland, C, Ivics, Z, Kantari-Mimoun, C, Kersten, M J, Köhl, U, Kuhn, C, Laugel, B, Locatelli, F, Marchiq, I, Markman, J, Moresco, M A, Morris, E, Negre, H, Quintarelli, C, Rade, M, Reiche, K, Renner, M, Ruggiero, E, Sanges, C, Stauss, H, Themeli, M, van den Brulle, J, Hudecek, M & Casucci, M 2022, ' Time to evolve : predicting engineered T cell-associated toxicity with next-generation models ', Journal for Immunotherapy of Cancer, vol. 10, no. 5 . https://doi.org/10.1136/jitc-2021-003486
Despite promising clinical results in a small subset of malignancies, therapies based on engineered chimeric antigen receptor and T-cell receptor T cells are associated with serious adverse events, including cytokine release syndrome and neurotoxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cc85efcc512b0862576aa25238c06f
https://pubmed.ncbi.nlm.nih.gov/35577500
https://pubmed.ncbi.nlm.nih.gov/35577500
Autor:
Esther Grueso, Zoltán Ivics, Andreas Mades, Cecilia Zuliani, Csaba Miskey, Markus Machwirth, Michael Hudecek, Irma Querques, Miriam Alb, Hermann Einsele, Tobias Rausch, Orsolya Barabas
Publikováno v:
Nature biotechnology
The Sleeping Beauty (SB) transposon system is an efficient non-viral gene transfer tool in mammalian cells, but its broad use has been hampered by uncontrolled transposase gene activity from DNA vectors, posing a risk of genome instability, and by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab90e90348f6c6390d5e613ed4b09ab8
https://doi.org/10.1038/s41587-019-0291-z
https://doi.org/10.1038/s41587-019-0291-z
Autor:
Elena Kromidas, Michael Hudecek, Madalena Cipriano, Cécile Zaupa, Lars Wallstabe, Peter Loskill, Birgit Fogal, Tengku Ibrahim Maulana, Miriam Alb
The advances in cancer immunotherapy come with several obstacles, limiting its widespread use and benefits so far only to a small subset of patients. One of the underlying challenges remains to be the lack of representative nonclinical models that tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c430e403d48b88cf5407abfe3be617dd
https://publica.fraunhofer.de/handle/publica/268253
https://publica.fraunhofer.de/handle/publica/268253
Autor:
Julia, Wallstabe, Lydia, Bussemer, Florian, Groeber-Becker, Lukas, Freund, Miriam, Alb, Mariola, Dragan, Ana Maria, Waaga-Gasser, Rafael, Jakubietz, Hermann, Kneitz, Andreas, Rosenwald, Silke, Rebhan, Heike, Walles, Stephan, Mielke
Publikováno v:
ALTEX. 37(3)
With cellular products being on the front run there is a rising demand for non-animal-based test platforms to predict, study and treat undesired immunity. Here, we generated human organotypic skin models from human biopsies isolating and expanding ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3ed418e1e977ba41301940473423cf4
https://pubmed.ncbi.nlm.nih.gov/32302003
https://pubmed.ncbi.nlm.nih.gov/32302003
Autor:
Miriam Alb, Julia Lange, Szymon Kurdyn, Silke Rebhan, Götz Gelbrich, Hermann Kneitz, Frederik Weil, Heike Walles, Stephan Mielke, Florian Groeber, Christoph Riegler
Publikováno v:
Biotechnology Journal. 11:1352-1361
Human artificial skin models are increasingly employed as non-animal test platforms for research and medical purposes. However, the overall histopathological quality of such models may vary significantly. Therefore, the effects of manufacturing proto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd148279860f755b1e6481c781da1b7
https://doi.org/10.1002/biot.201600360
https://doi.org/10.1002/biot.201600360
Autor:
Miriam Alb, Peter U. Heuschmann, Hermann Einsele, Ulrike Kämmerer, Stephan Mielke, Mathias Lutz, Andrea Worschech, Laura Bernhard, Sabine Gahn, Michael Schwab, Erdwine Klinker, Stefanie Obermeier, Christoph Otto
Publikováno v:
Blood. 125:261-272
Background The therapeutic potential of allogeneic hematopoietic stem cell transplantation (HSCT) mainly relies on graft-versus-leukemia effects mediated by donor-derived T cells targeting both minor histocompatibility antigens and tumor-associated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b51e55d2c26c62afb333d55aa12f2c
https://doi.org/10.1182/blood-2014-09-601302
https://doi.org/10.1182/blood-2014-09-601302
Publikováno v:
Cancer Immunology, Immunotherapy
Grm1-transgenic mice spontaneously develop cutaneous melanoma. This model allowed us to scrutinize the generic immune responses over the course of melanoma development. To this end, lymphocytes obtained from spleens, unrelated lymph nodes and tumor-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18737d843146ecf1ce87af60f8b6a9c0
http://europepmc.org/articles/PMC3506202
http://europepmc.org/articles/PMC3506202
Autor:
Christoph Willmes, David Schrama, Lena Völkert, Roland Houben, Miriam Alb, Christian Adam, Juergen C. Becker
Publikováno v:
Cancer Research. 72:2120-2128
Merkel cell carcinoma (MCC) is a rare and highly aggressive skin cancer associated with the Merkel cell polyomavirus (MCV). As MCC cell lines show oncogene addiction to the MCV T antigens, pharmacologic interference of the large T antigen (LTA) may r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff69065381c8988a064919212ba6c9e
https://doi.org/10.1158/0008-5472.can-11-2651
https://doi.org/10.1158/0008-5472.can-11-2651