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Oncometabolites suppress DNA repair by disrupting local chromatin signalling.

Autor: Sulkowski PL; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Oeck S; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Medical Oncology, University of Duisburg-Essen, Essen, Germany., Dow J; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Economos NG; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Mirfakhraie L; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA., Liu Y; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA., Noronha K; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, USA., Bao X; Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA., Li J; Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA., Shuch BM; Department of Urology, University of California at Los Angeles, Los Angeles, CA, USA., King MC; Department of Cell Biology, Yale University School of Medicine, New Haven, CT, USA., Bindra RS; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA. ranjit.bindra@yale.edu.; Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. ranjit.bindra@yale.edu., Glazer PM; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA. peter.glazer@yale.edu.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. peter.glazer@yale.edu.

Publikováno v: Nature [Nature] 2020 Jun; Vol. 582 (7813), pp. 586-591. Date of Electronic Publication: 2020 Jun 03.

Tricarboxylic Acid Cycle Relationships with Non-Metabolic Processes: A Short Story with DNA Repair and Its Consequences on Cancer Therapy Resistance.

Autor: Álvarez-González, Enol^1,2,3 (AUTHOR) enolalvglez@hotmail.com, Sierra, Luisa María^1,2,3 (AUTHOR) lmsierra@uniovi.es

Publikováno v: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 16, p9054. 25p.

Identification of mIDH1 R132C/S280F Inhibitors from Natural Products by Integrated Molecular Docking, Pharmacophore Modeling and Molecular Dynamics Simulations.

Autor: Zhang, Weitong¹ (AUTHOR) 222031711625@email.sntcm.edu.cn, Bai, Hailong¹ (AUTHOR) 223040011852@email.sntcm.edu.cn, Wang, Yifan¹ (AUTHOR) 222031712627@email.sntcm.edu.cn, Wang, Xiaorui² (AUTHOR) wangxr2018@lzu.edu.cn, Jin, Ruyi¹ (AUTHOR) jinruyi335588@163.com, Guo, Hui¹ (AUTHOR) guohui@sntcm.edu.cn, Lai, Huanling³ (AUTHOR) laihl910@126.com, Tang, Yuping¹ (AUTHOR) yupingtang@sntcm.edu.cn, Wang, Yuwei¹ (AUTHOR) wangyw09@gmail.com

Publikováno v: Pharmaceuticals (14248247). Mar2024, Vol. 17 Issue 3, p336. 20p.

Ribosomal S6 kinase (RSK) plays a critical role in DNA damage response via the phosphorylation of histone lysine demethylase KDM4B.

Autor: Wu, Wenwen, Zhu, Jing, Nihira, Naoe Taira, Togashi, Yukiko, Goda, Atsushi, Koike, Junki, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Tomita, Takuya, Saeki, Yasushi, Johmura, Yoshikazu, Nakanishi, Makoto, Miyoshi, Yasuo, Ohta, Tomohiko

Publikováno v: Breast Cancer Research; 10/21/2024, Vol. 26 Issue 1, p1-14, 14p