Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Miren K. Aiertza"'
Autor:
Pattama Senthong, Geoffrey P. Margison, Oliver J. Wilkinson, Kabir Abdu, Timothy D. Craggs, David M. Williams, Miren K. Aiertza, Andrew C. Povey
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 39:1108-1121
Promutagenic O6-alkylguanine adducts in DNA are repaired in humans by O6-methylguanine-DNA-methyltransferase (MGMT) in an irreversible reaction. Here we describe the synthesis of a phosphoramidite that allows the preparation of oligodeoxyribonucleoti
Autor:
Kabir, Abdu, Miren K, Aiertza, Oliver J, Wilkinson, Pattama, Senthong, Timothy D, Craggs, Andrew C, Povey, Geoffrey P, Margison, David M, Williams
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 39(8)
Promutagenic
Autor:
Adam J. M. Burrell, Geoffrey P. Margison, Dolorès Edmont, Miren K. Aiertza, Harry Adams, David M. Hammond, Takayuki Shibata, David M. Williams, Ana R. Hornillo-Araujo
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 26:1099-1102
The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of O(6)-methylguanine and S(6)-methylthioguanine are described. The crystal structures and pK(a) values of these analogues are reported. In a standard substrate assay with the human
Autor:
David M. Williams, Jane A. Grasby, Andrew C. Povey, Oliver J. Wilkinson, Geoffrey P. Margison, Pattama Senthong, Kabir Abdu, Miren K. Aiertza
Publikováno v:
Chemical communications (Cambridge, England). 48(91)
We show that DNA containing a conformationally-locked anti analogue of O(6)-alkylguanine is a poor substrate for human O(6)-methylguanine-DNA methyltransferase (MGMT) and the alkyltransferase-like protein, Atl1. This highlights the requirement for th
Autor:
Dolorès Edmont, Ana R. Hornillo-Araujo, Adam J. M. Burrell, David M. Hammond, Harry Adams, Miren K. Aiertza, David M. Williams, Takayuki Shibata, Geoffrey P. Margison
Publikováno v:
ChemInform. 39
Autor:
Geoffrey P. Margison, Adam J. M. Burrell, Takayuki Shibata, Ana R. Hornillo-Araujo, Dolorès Edmont, David M. Hammond, Miren K. Aiertza, Harry Adams, David M. Williams
Publikováno v:
Organicbiomolecular chemistry. 4(9)
The syntheses of novel tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine are described. The crystal structures and pKa values of these and related O6-methylguanine analogues are reported. All compounds display higher pKa values tha