Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy.

Autor: Oscar Murcia, Míriam Juárez, María Rodríguez-Soler, Eva Hernández-Illán, Mar Giner-Calabuig, Miren Alustiza, Cecilia Egoavil, Adela Castillejo, Cristina Alenda, Víctor Barberá, Carolina Mangas-Sanjuan, Ana Yuste, Luís Bujanda, Joan Clofent, Montserrat Andreu, Antoni Castells, Xavier Llor, Pedro Zapater, Rodrigo Jover

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203051 (2018)

OBJECTIVE:The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype's response to

Externí odkaz: https://doaj.org/article/16decb5c201c4161a4fffd312ee4174c

Clinical significance of a microRNA signature for the identification and predicting prognosis in colorectal cancers with mucinous differentiation

Autor: Francesc Balaguer, Juan Ruiz-Bañobre, Miren Alustiza Fernández, Miguel Pera, Roshni Roy, Ajay Goel, Rodrigo Jover, Rafael López-López, Oscar Murcia

Publikováno v: Carcinogenesis

Accumulating evidence supports the fact that the mere presence of mucinous differentiation in colorectal cancer (CRC), rather than its proportion, is a more accurate representative of a particular CRC subtype with distinct clinical and molecular feat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38211d37e36af068974c6fa135b935ee
https://doi.org/10.1093/carcin/bgaa097

Increased Th17-Related Cytokine Serum Levels in Patients With Multiple Polyps of Unexplained Origin

Autor: Luisa De-Castro, Alejandro Martínez-Roca, Claudia Martínez-Cardona, Miren Alustiza, Rubén Francés, Alberto Herreros-de-Tejada, Francisco Rodríguez-Moranta, Paula Giménez, Mar Giner-Calabuig, Cristina Mira, Fernando Fernández-Bañares, Joaquín Cubiella, Oscar Murcia, Luis Bujanda, David Nicolás-Pérez, Miriam Juárez, Eva Hernández-Illán, Rodrigo Jover, JC Marín-Gabriel

Publikováno v: Clinical and Translational Gastroenterology
Addi. Archivo Digital para la Docencia y la Investigación
instname
Dipòsit Digital de la UB
Universidad de Barcelona

OBJECTIVES: Most patients with multiple colonic polyps do not have a known genetic or hereditary origin. Our aim was to analyze the presence of inflammatory cytokines and levels of glucose, insulin, and C-reactive protein (CRP) in patients with multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea26de8fedf3907c98ca906cdc30021
http://europepmc.org/articles/PMC7145049

Effects of Somatic Methylation in Colonic Polyps on Risk of Developing Metachronous Advanced Colorectal Lesions

Autor: Cristina Alenda, Rodrigo Jover, Maria Rodriguez-Soler, Francisco Antonio Ruiz-Gómez, Alejandro Martínez-Roca, Sandra Baile-Maxía, Artemio Payá, Cristina Mira, Miren Alustiza, Eva Serrano, Miriam Juárez, Oscar Murcia, Pedro Zapater, Carolina Mangas-Sanjuan, Lucía Medina, Mar Giner-Calabuig

Publikováno v: Cancers
Volume 13
Issue 2
Cancers, Vol 13, Iss 246, p 246 (2021)

The utility of molecular markers for predicting the risk of metachronous advanced colorectal lesions (MACLs) remains poorly investigated. We examined the relationship between somatic hypermethylation in polyps at baseline and the risk of developing M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2cbcb5bf5835654382a9fa9a1f69830
https://doi.org/10.3390/cancers13020246

Clinical and Pathological Characterization of Lynch-Like Syndrome

Autor: Teresa Ramón y Cajal, Ariadna Sánchez, Maria Pellise, Mar Giner-Calabuig, Francesc Balaguer, Maite Herraiz, Luis Bujanda, Adela Castillejo, Cristina Alenda, Leticia Moreira, María Dolores Picó, Rodrigo Jover, Lucía Cid, Adrià López-Fernández, Marta Garzon, Miren Alustiza, Marta Ponce, Antoni Castells, Cristina Alvarez-Urturi, Carmen Poves, Inmaculada Salces, Luis Hernández-Villalba, Laura Rivas, Catalina Garau, Oscar Murcia, Daniel Rodríguez-Alcalde, Carmen Yagüe, Joaquín Cubiella, José-Luis Soto, Carlos Dolz, Alexandra Gisbert-Beamud, Gemma Llort, Marta Carrillo-Palau

Publikováno v: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
r-FISABIO. Repositorio Institucional de Producción Científica
instname
Clinical Gastroenterology and Hepatology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante

BACKGROUND & AIMS: Lynch syndrome is characterized by DNA mismatch repair (MMR) deficiency. Some patients with suspected Lynch syndrome have DNA MMR deficiencies but no detectable mutations in genes that encode MMR proteins-this is called Lynch-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ddff44ec51a141212a4a8c9bb5abf7c
https://doi.org/10.1016/j.cgh.2019.06.012