Insight into the Folding and Dimerization Mechanisms of the N-Terminal Domain from Human TDP-43

Autor: Mirella Vivoli-Vega, Prandvera Guri, Fabrizio Chiti, Francesco Bemporad

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 17, p 6259 (2020)

TAR DNA-binding protein 43 (TDP-43) is a 414-residue long nuclear protein whose deposition into intraneuronal insoluble inclusions has been associated with the onset of amyotrophic lateral sclerosis (ALS) and other diseases. This protein is physiolog

Externí odkaz: https://doaj.org/article/e04bf9182b664d30af90067507c06022

Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major

Autor: Jua Iwasaki, Donald D. Lorimer, Mirella Vivoli-Vega, Emily A. Kibble, Christopher S. Peacock, Jan Abendroth, Stephen J. Mayclin, David M. Dranow, Phillip G. Pierce, David Fox, Maria Lewis, Nicole M. Bzdyl, Sofie S. Kristensen, Timothy J. J. Inglis, Charlene M. Kahler, Charles S. Bond, Anja Hasenkopf, Florian Seufert, Jens Schmitz, Laura E. Marshall, Andrew E. Scott, Isobel H. Norville, Peter J. Myler, Ulrike Holzgrabe, Nicholas J. Harmer, Mitali Sarkar-Tyson

Publikováno v: Journal of Antimicrobial Chemotherapy. 77:1625-1634

Background The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in a wide range of pathogenic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ca13736e17f6f376896275651f4a70
https://doi.org/10.1093/jac/dkac065

Conversion of the Native N-Terminal Domain of TDP-43 into a Monomeric Alternative Fold with Lower Aggregation Propensity

Autor: Matteo Moretti, Isabella Marzi, Cristina Cantarutti, Mirella Vivoli Vega, Walter Mandaliti, Maria Chiara Mimmi, Francesco Bemporad, Alessandra Corazza, Fabrizio Chiti

Publikováno v: Molecules; Volume 27; Issue 13; Pages: 4309
Moretti, M, Marzi, I, Cantarutti, C, Vivoli Vega, M, Mandaliti, W, Mimmi, M C, Bemporad, F & Chiti, F 2022, ' Conversion of the Native N-Terminal Domain of TDP-43 into a Monomeric Alternative Fold with Lower Aggregation Propensity. ', Molecules, vol. 27, no. 13, 4309 . https://doi.org/10.3390/molecules27134309

TAR DNA-binding protein 43 (TDP-43) forms intraneuronal cytoplasmic inclusions associated with amyotrophic lateral sclerosis and ubiquitin-positive frontotemporal lobar degeneration. Its N-terminal domain (NTD) can dimerise/oligomerise with the head-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3e39b9fc825aaaf89c5b09dbf088c6

The ROK kinase N-acetylglucosamine kinase uses a sequential random enzyme mechanism with successive conformational changes upon each substrate binding

Autor: Sumita Roy, Mirella Vivoli Vega, Jessica R. Ames, Nicole Britten, Amy Kent, Kim Evans, Michail N. Isupov, Nicholas J. Harmer

Publikováno v: Journal of Biological Chemistry. 299:103033

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0215d3c3e65e0a38daf080ca92ba70e1
https://doi.org/10.1016/j.jbc.2023.103033

No-nonsense: insights into the functional interplay of nonsense-mediated mRNA decay factors

Autor: Justine Mailliot, Mirella Vivoli-Vega, Christiane Schaffitzel

Publikováno v: Mailliot, J M, Vivoli Vega, M & Berger-Schaffitzel, C H 2022, ' No-nonsense : insights into the functional interplay of nonsense-mediated mRNA decay factors ', Biochemical Journal, vol. 479, no. 9, pp. 973-993 . https://doi.org/10.1042/BCJ20210556

Nonsense-mediated messenger RNA decay (NMD) represents one of the main surveillance pathways used by eukaryotic cells to control the quality and abundance of mRNAs and to degrade viral RNA. NMD recognises mRNAs with a premature termination codon (PTC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fada9c315f09fb750ee49c0092b45f1
https://pubmed.ncbi.nlm.nih.gov/35551602