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Autor:
Theodore R. Holman, Melinee D’silva, Harman S. Brah, Wan-Chen Tsai, Jennyfer Tena, Ansari Mukhtar Aleem, Chakrapani Kalyanaraman, Mirella Rivera-Velazquez, Sarvind Tripathi, Matthew P. Jacobson, Jerry L. Nadler
Publikováno v:
Bioorganic & Medicinal Chemistry. 46:116347
Human platelet 12-(S)-Lipoxygenase (12-LOX) is a fatty acid metabolizing oxygenase that plays an important role in platelet activation and cardiometabolic disease. ML355 is a specific 12-LOX inhibitor that has been shown to decrease thrombosis withou