Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mirela Milescu"'
Autor:
Marco A Navarro, Autoosa Salari, Jenna L Lin, Luke M Cowan, Nicholas J Penington, Mirela Milescu, Lorin S Milescu
Publikováno v:
eLife, Vol 9 (2020)
Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in
Externí odkaz:
https://doaj.org/article/24456da1dd444b96a12bd4105188c12d
Autor:
Kanchan Gupta, Maryam Zamanian, Chanhyung Bae, Mirela Milescu, Dmitriy Krepkiy, Drew C Tilley, Jon T Sack, Vladimir Yarov-Yarovoy, Jae Il Kim, Kenton J Swartz
Publikováno v:
eLife, Vol 4 (2015)
Tarantula toxins that bind to voltage-sensing domains of voltage-activated ion channels are thought to partition into the membrane and bind to the channel within the bilayer. While no structures of a voltage-sensor toxin bound to a channel have been
Externí odkaz:
https://doaj.org/article/2a3a2a4aa18b41e9b71934a7e5d3b457
Publikováno v:
Methods in Molecular Biology ISBN: 9781071617663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fc5d51b0bea7f1153e0e00a2efd3c60
https://doi.org/10.1007/978-1-0716-1767-0_17
https://doi.org/10.1007/978-1-0716-1767-0_17
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2385
Ion channels play a central role in membrane physiology, but to fully understand how they operate, one must have accurate kinetic mechanisms. Estimating kinetics is not trivial when the mechanism is complex, and a large number of parameters must be e
Publikováno v:
Journal of General Physiology. 151:275-278
The Boa constrictor uses its powerful muscles to suffocate and kill its prey. Unlike the mighty Goliath, smart little David—spiders, scorpions, and other venomous creatures—uses an arsenal of toxins to inflict pain, paralyze, and kill. In the ion
Autor:
Autoosa Salari, Nicholas J. Penington, Marco A. Navarro, Luke M Cowan, Mirela Milescu, Jenna L. Lin, Lorin S. Milescu
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Voltage-gated sodium channels play a critical role in cellular excitability, amplifying small membrane depolarizations into action potentials. Interactions with auxiliary subunits and other factors modify the intrinsic kinetic mechanism to result in
Publikováno v:
The Journal of General Physiology
In their preceding paper, Salari et al. describe a formalism that allows existing knowledge to be enforced into kinetic models. Here, Navarro et al. present a penalty-based optimization mechanism to incorporate arbitrary parameter relationships and c
Autor:
Andriy Anishkin, Marzie Amirshenava, Mirela Milescu, Lorin S. Milescu, Aditi Mishra, Sergei Sukharev
Publikováno v:
Biophysical Journal. 118:276a
Publikováno v:
The Journal of General Physiology
New mathematical tools are needed to incorporate existing knowledge into kinetic models of ion channels and other proteins. Salari et al. describe an algebraic transformation that can enforce linearly interdependent parameters into kinetic models in