Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mirela Matecic"'
Autor:
Mirela Matecic, Daniel L Smith, Xuewen Pan, Nazif Maqani, Stefan Bekiranov, Jef D Boeke, Jeffrey S Smith
Publikováno v:
PLoS Genetics, Vol 6, Iss 4, p e1000921 (2010)
Model organisms have played an important role in the elucidation of multiple genes and cellular processes that regulate aging. In this study we utilized the budding yeast, Saccharomyces cerevisiae, in a large-scale screen for genes that function in t
Externí odkaz:
https://doaj.org/article/1863f3cc50554275afff2d5bad3101f2
Autor:
Anindya Dutta, Christopher A. Moskaluk, Roderick V. Jensen, Clive Evans, Mirela Matecic, Hak Kyun Kim, Ankit Malhotra, Yong Sun Lee, Dandan Sun
Supplementary Tables 1-4, Figures 1-11 from miR-99 Family of MicroRNAs Suppresses the Expression of Prostate-Specific Antigen and Prostate Cancer Cell Proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c437c9e7310b8b0b9440e39f801788
https://doi.org/10.1158/0008-5472.22385969.v1
https://doi.org/10.1158/0008-5472.22385969.v1
Autor:
Margaret B. Wierman, Jeffrey S. Smith, Veena Valsakumar, Stefan Bekiranov, Mirela Matecic, Mingguang Li, Daniel L. Smith
Publikováno v:
Aging (Albany NY)
Yeast chronological lifespan (CLS) is extended by multiple genetic and environmental manipulations, including caloric restriction (CR). Understanding the common changes in molecular pathways induced by such manipulations could potentially reveal cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6b72f79e65f129fc788456a36d80b1
https://doi.org/10.18632/aging.100729
https://doi.org/10.18632/aging.100729
Autor:
Dandan Sun, Clive Evans, Yong Sun Lee, Christopher A. Moskaluk, Anindya Dutta, Mirela Matecic, Roderick V. Jensen, Hak Kyun Kim, Ankit Malhotra
Publikováno v:
Cancer Research. 71:1313-1324
MicroRNAs (miRNA) have been globally profiled in cancers but there tends to be poor agreement between studies including in the same cancers. In addition, few putative miRNA targets have been validated. To overcome the lack of reproducibility, we prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f678bf1c773a6c4647aa1c65d74aa70e
https://doi.org/10.1158/0008-5472.can-10-1031
https://doi.org/10.1158/0008-5472.can-10-1031
Autor:
Daniel L. Smith, Christopher M. Gallo, Mirela Matecic, Stephen W. Buck, Jeffrey S. Smith, Robert D. Hontz, Frances G. Racette, Julie M. McClure
Publikováno v:
Genetics. 180:797-810
The histone deacetylase activity of Sir2p is dependent on NAD+ and inhibited by nicotinamide (NAM). As a result, Sir2p-regulated processes in Saccharomyces cerevisiae such as silencing and replicative aging are susceptible to alterations in cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835731877480174cf8126d53911755f7
https://doi.org/10.1534/genetics.108.091090
https://doi.org/10.1534/genetics.108.091090
Publikováno v:
Aging Cell. 6:649-662
Calorie restriction (CR) extends the mean and maximum lifespan of a wide variety of organisms ranging from yeast to mammals, although the molecular mechanisms of action remain unclear. For the budding yeast Saccharomyces cerevisiae reducing glucose i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab920d64351976e0329823ade4dc3b6b
https://doi.org/10.1111/j.1474-9726.2007.00326.x
https://doi.org/10.1111/j.1474-9726.2007.00326.x
Autor:
Scott G. Holmes, Jason C. Tanny, Danesh Moazed, Mirela Matecic, Merrit Hickman, Kristen Martins-Taylor
Publikováno v:
Genetics. 173:1939-1950
The establishment of transcriptional silencing in yeast requires cell-cycle progression, but the nature of this requirement is unknown. Sir2 is a protein deacetylase that is required for gene silencing in yeast. We have used temperature-sensitive all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783d38818d0d95d600d7b15060758c70
https://doi.org/10.1534/genetics.106.055491
https://doi.org/10.1534/genetics.106.055491
Publikováno v:
Journal of Virology. 71:6842-6849
We have examined mechanisms of recombination in mammalian cells infected with herpes simplex virus type 1 (HSV-1). Amplification of plasmids containing a viral origin of replication, oriS, in cells superinfected with HSV-1 revealed that linear DNA co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23597e5b1d18f2d7d3480f2200e5493d
https://doi.org/10.1128/jvi.71.9.6842-6849.1997
https://doi.org/10.1128/jvi.71.9.6842-6849.1997
Summary Aging research has developed rapidly over the past decade, identifying individual genes and molecular mechanisms of the aging process through the use of model organisms and high throughput technologies. Calorie restriction (CR) is the most wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7e9615bb5873457f08bf76b19824a4
https://europepmc.org/articles/PMC3163344/
https://europepmc.org/articles/PMC3163344/
Autor:
Mirela Matecic, Nazif Maqani, Jef D. Boeke, Daniel L. Smith, Stefan Bekiranov, Jeffrey S. Smith, Xuewen Pan
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 6, Iss 4, p e1000921 (2010)
PLoS Genetics, Vol 6, Iss 4, p e1000921 (2010)
Model organisms have played an important role in the elucidation of multiple genes and cellular processes that regulate aging. In this study we utilized the budding yeast, Saccharomyces cerevisiae, in a large-scale screen for genes that function in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe690886fe4a35e878cdf05e24375b7
https://pubmed.ncbi.nlm.nih.gov/20421943
https://pubmed.ncbi.nlm.nih.gov/20421943