EF24, a schistosomicidal curcumin analog: Insights from its synthesis and phenotypic, biochemical and cytotoxic activities

Autor: Fernanda R. Badoco, Lucas A.L. Paula, Renato P. Orenha, Tiago M.F. Mendes, Iara S. Squarisi, Nelly El-Sakkary, Messias C. Loiola, Naftale Katz, Denise C. Tavares, Mirela I. Sairre, Renato Luis T. Parreira, Fernanda Janku Cabral, Silmara M. Alegretti, Conor R. Caffrey, Lizandra G. Magalhães

Publikováno v: Chemico-Biological Interactions. 368:110191

Praziquantel (PZQ) is the only drug available for community-based control programs which aim to reduce the prevalence and morbidity associated with schistosomiasis. Here, we synthesized and evaluated the schistosomicidal, biochemical and cytotoxic ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f5848aabe69c932a86a3a8711b735b
https://doi.org/10.1016/j.cbi.2022.110191

ChemInform Abstract: New Approach to the Synthesis of the Natural Product Aripuanin

Autor: Paulo Marcos Donate, Mirela I. Sairre, Aline S. Lazaro, Pedro H. Zana Ribeiro

Publikováno v: ChemInform. 46

Aripuanin is a megastigmane that exists in the leaves of Ficus aripuanensis C.C. Berg (Moraceae). The present study describes a new approach to the total synthesis of this natural product starting from the readily available β-ionone. The proposed sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::671188b92658518779e61eac3ddd751e
https://doi.org/10.1002/chin.201535224

Synthesis of analogues of thyroid hormones: nuclear receptor modulators

Autor: Paulo Marcos Donate, Mirela I. Sairre, Carlos Frederico Duarte Rocha, Vitor Lacerda Sanches, Rosangela da Silva de Laurentiz, Guilherme Vieira de Castro, Igor Polikarpov, Pedro H. Zana Ribeiro

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Orbital: The Electronic Journal of Chemistry, Vol 7, Iss 3, Pp 282-291 (2015)

Made available in DSpace on 2018-11-26T16:05:25Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-07-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb7e640b2570a82b8ce2c239b4f4705

Conformational influence on intramolecular cyclization for a β-ketoester containing oxirane ring: A theoretical and experimental study

Autor: Erika S. Bronze-Uhle, Paulo Marcos Donate, Mirela I. Sairre, Cláudio F. Tormena

Publikováno v: Journal of Molecular Structure. 794:221-224

Conformational preference for the (oxiran-2-ylmethyl 3-oxobutanoate) ( 11 ) (β-ketoester) was studied using theoretical calculation and experimental data to demonstrate the influence of the conformation on the absence of intramolecular cyclization r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d777071a753298f54dab4ba8fb49b0b6
https://doi.org/10.1016/j.molstruc.2006.02.017

A new approach to the synthesis of natural product Aripuanin

Autor: Mirela I. Sairre, Paulo Marcos Donate, Aline Simões Lazaro

Publikováno v: Proceedings of the 14th Brazilian Meeting on Organic Synthesis Proceedings.

Scheme 1. Preparation of the Aripuanin (1). RESULTS AND DISCUSSION According to Scheme 1, the β-ionone (2) was submitted to a bromination reaction using Nbromosuccinimide (NBS) in carbon tetrachloride, under the heating of a tungsten lamp of 100 W.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e81c2693329626d6a01e4b115888e76
https://doi.org/10.5151/chempro-14bmos-r0301-2