Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Mirela, Kuka"'
LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness
Autor:
Isabella Pallavicini, Teresa Maria Frasconi, Carlotta Catozzi, Elena Ceccacci, Silvia Tiberti, Dorothee Haas, Jule Samson, Christoph Heuser-Loy, Carina B. Nava Lauson, Marta Mangione, Elisa Preto, Alberto Bigogno, Eleonora Sala, Matteo Iannacone, Ciro Mercurio, Luca Gattinoni, Ignazio Caruana, Mirela Kuka, Luigi Nezi, Saverio Minucci, Teresa Manzo
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The lysine-specific histone demethylase 1 A (LSD1) is involved in antitumor immunity; however, its role in shaping CD8 + T cell (CTL) differentiation and function remains largely unexplored. Here, we show that pharmacological inhibition of L
Externí odkaz:
https://doaj.org/article/79a6302e7fd8421489f3328a337cb7b0
Autor:
Liat Stoler-Barak, Ethan Harris, Ayelet Peres, Hadas Hezroni, Mirela Kuka, Pietro Di Lucia, Amalie Grenov, Neta Gurwicz, Meital Kupervaser, Bon Ham Yip, Matteo Iannacone, Gur Yaari, John D. Crispino, Ziv Shulman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection throug
Externí odkaz:
https://doaj.org/article/431be3cd018542aa832ba2a735ae482b
Autor:
Francesco Andreata, Camille Blériot, Pietro Di Lucia, Giorgia De Simone, Valeria Fumagalli, Xenia Ficht, Cristian Gabriel Beccaria, Mirela Kuka, Florent Ginhoux, Matteo Iannacone
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100831- (2021)
Summary: Here, we provide detailed protocols for the isolation of mouse Kupffer cells – the liver-resident macrophages – for phenotypic (e.g., via flow cytometry, mass cytometry, or RNA-sequencing) analyses or for functional experiments involving
Externí odkaz:
https://doaj.org/article/789fccb91ed1475794b87f517ec97729
Autor:
Maya Fedeli, Mirela Kuka, Annamaria Finardi, Francesca Albano, Valentina Viganò, Matteo Iannacone, Roberto Furlan, Paolo Dellabona, Giulia Casorati
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 9, Pp n/a-n/a (2021)
Abstract Objective miR‐21 is highly expressed in iNKT and activated T cells, but its T‐cell autonomous functions are poorly defined. We sought to investigate the role of miR‐21 in the development and functions of T and iNKT cells, representing
Externí odkaz:
https://doaj.org/article/6945cde2c3e2426a802bc123cb63abe9
Autor:
Alessandra Fiore, Eleonora Sala, Chiara Laura, Michela Riba, Maria Nelli, Valeria Fumagalli, Federico Oberrauch, Marta Mangione, Claudia Cristofani, Paolo Provero, Matteo Iannacone, Mirela Kuka
TDCare hematopoietic cells that combine dendritic cell (DC) and conventional T cell markers and functional properties. They were identified in secondary lymphoid organs (SLOs) of naïve mice as cells expressing CD11c, major histocompatibility molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd00247ecd20588358017b6a4a4b74b0
https://doi.org/10.1101/2023.04.06.535573
https://doi.org/10.1101/2023.04.06.535573
Autor:
Tatiana Jofra, Giuseppe Galvani, Mirela Kuka, Roberta Di Fonte, Bechara G. Mfarrej, Matteo Iannacone, Shahram Salek-Ardakani, Manuela Battaglia, Georgia Fousteri
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
A genetic variant of the protein tyrosine phosphatase non-receptor 22 (PTPN22) is associated with a wide range of autoimmune diseases; however, the reasons behind its prevalence in the general population remain not completely understood. Recent evide
Externí odkaz:
https://doaj.org/article/e598bea8d3254c658eae189ea8476fe3
Autor:
Liat Stoler-Barak, Ethan Harris, Ayelet Peres, Hadas Hezroni, Mirela Kuka, Amalie Grenov, Neta Gurwicz, Meital Kupervaser, Bon Ham Yip, Matteo Iannacone, Gur Yaari, John Crispino, Ziv Shulman
Protection from viral infections depends on immunoglobulin isotype switching, which endows antibodies with effector functions. Here, we found that the protein kinase DYRK1A is essential for B cell-mediated protection from viral infection and effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ca15005d93b440e758e7f2ec8939241
https://doi.org/10.21203/rs.3.rs-1779641/v1
https://doi.org/10.21203/rs.3.rs-1779641/v1
Autor:
Lisa Sandner, Marlis Alteneder, Ramona Rica, Barbara Woller, Eleonora Sala, Tobias Frey, Anela Tosevska, Ci Zhu, Moritz Madern, Pol Hoffmann, Alexandra Schebesta, Ichiro Taniuchi, Michael Bonelli, Klaus Schmetterer, Matteo Iannacone, Mirela Kuka, Wilfried Ellmeier, Shinya Sakaguchi, Ruth Herbst, Nicole Boucheron
T follicular helper (Tfh) cells are essential for the development of germinal center B cells and high-affinity antibody producing B-cells in human and mice. Here, we identify the guanine nucleotide exchange factor (GEF) Rin-like (Rinl) as a negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98f220eaec046b889f50abf0fee3e14e
https://doi.org/10.1101/2022.06.23.497284
https://doi.org/10.1101/2022.06.23.497284
Autor:
Valeria Fumagalli, Valentina Venzin, Pietro Di Lucia, Federica Moalli, Xenia Ficht, Gioia Ambrosi, Leonardo Giustini, Francesco Andreata, Marta Grillo, Diletta Magini, Micol Ravà, Christin Friedrich, Jason D. Fontenot, Philippe Bousso, Sarah A. Gilmore, Shahzada Khan, Manuel Baca, Eric Vivier, Georg Gasteiger, Mirela Kuka, Luca G. Guidotti, Matteo Iannacone
Publikováno v:
Science Immunology
Science Immunology, 2022, 7 (68), ⟨10.1126/sciimmunol.abi6112⟩
Science Immunology, 2022, 7 (68), ⟨10.1126/sciimmunol.abi6112⟩
Group 1 innate lymphoid cells (ILCs), which comprise both natural killer (NK) cells and ILC1s, are important innate effectors that can also positively and negatively influence adaptive immune responses. The latter function is generally ascribed to th
Autor:
Mirela Kuka, Georgia Fousteri
Publikováno v:
Molecular Immunology. 119:101-105
Our knowledge on the development and functions of CXCR5+ CD8 T cells is rudimentary when confronted to other extensively studied CD8 T cell subsets. A decade ago, it became apparent that CD8 T cells possess two additional and rather unexpected functi