Výsledky vyhledávání - "Mireille H. G. Indemans"

A top-down analysis of Xa- and Xi-territories reveals differences of higher order structure at ≥ 20 Mb genomic length scales

Autor: Thomas Cremer, Rogier Versteeg, Doris Illner, Corella S. Casas-Delucchi, Mireille H. G. Indemans, Kathrin Teller, Stefanie Thamm, Marion Cremer

Publikováno v: Nucleus (Austin, Tex.), 2(5), 465-477. Landes Bioscience

The active and inactive X (Xa;Xi) territory with its seemingly highly compacted Barr body in nuclei of female mammalian cells provide a key example for studies of structure/function relationships in homologous chromosomes with different functional pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65f28fb9e8bcf375e6dab20a620f811
https://doi.org/10.4161/nucl.2.5.17862

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Domain-wide regulation of gene expression in the human genome

Autor: Hinco J. Gierman, Roel van Driel, Jan Koster, Mireille H. G. Indemans, Dirk Geerts, Sandra Goetze, Rogier Versteeg, Jurgen Seppen

Publikováno v: Gierman, H J, Indemans, M H G, Koster, J, Goetze, S, Seppen, J, Geerts, D, van Driel, R & Versteeg, R 2007, ' Domain-wide regulation of gene expression in the human genome ', Genome Research, vol. 17, no. 9, pp. 1286-95 . https://doi.org/10.1101/gr.6276007
Genome research, 17(9), 1286-1295. Cold Spring Harbor Laboratory Press
Genome Research, 17(9), 1286-95. Cold Spring Harbor Laboratory Press
Genome Research, 17(9), 1286-1295. Cold Spring Harbor Laboratory Press

Transcription factor complexes bind to regulatory sequences of genes, providing a system of individual expression regulation. Targets of distinct transcription factors usually map throughout the genome, without clustering. Nevertheless, highly and we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dca61161186418f9bbc2b5f0afbdbf7
https://doi.org/10.1101/gr.6276007

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Spatially confined folding of chromatin in the interphase nucleus

Autor: Pernette J. Verschure, Osdilly Giromus, Sandra Goetze, Erik M. M. Manders, Julio Mateos-Langerak, Dieter W. Heermann, Roel van Driel, Hinco J. Gierman, Manfred Bohn, Wim C. de Leeuw, Mireille H. G. Indemans

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 106(10), 3812-3817. National Academy of Sciences

Genome function in higher eukaryotes involves major changes in the spatial organization of the chromatin fiber. Nevertheless, our understanding of chromatin folding is remarkably limited. Polymer models have been used to describe chromatin folding. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffd16568c1e9edb1f2954eeb798cd8
https://dare.uva.nl/personal/pure/en/publications/spatially-confined-folding-of-chromatin-in-the-interphase-nucleus(a0d66949-ee6f-49fa-b467-76cbb71aee70).html

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The three-dimensional structure of human interphase chromosomes is related to the transcriptome map

Autor: Hinco J. Gierman, Sandra Goetze, Vladan Ondrej, Osdilly Giromus, Julio Mateos-Langerak, Rogier Versteeg, Mireille H. G. Indemans, Roel van Driel, Wim de Leeuw, Jan Koster

Publikováno v: Molecular and cellular biology, 27(12), 4475-4487. American Society for Microbiology
Molecular and Cellular Biology, 27(12), 4475-4487. American Society for Microbiology

The three-dimensional (3D) organization of the chromosomal fiber in the human interphase nucleus is an important but poorly understood aspect of gene regulation. Here we quantitatively analyze and compare the 3D structures of two types of genomic dom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49fb311391a7db480f388ce918b58af
https://pure.amc.nl/en/publications/the-threedimensional-structure-of-human-interphase-chromosomes-is-related-to-the-transcriptome-map(ee10f2ce-67e2-4a3b-9e56-4613a0262a4a).html

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