Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Mireille H, Lahoud"'
Autor:
Rajan Venkatraman, Katherine R. Balka, Wilson Wong, Jananipriya Sivamani, Zoe Magill, Kirsteen M. Tullett, Rachael M. Lane, Tahnee L. Saunders, Maximilien Tailler, Peter J. Crack, Linda M. Wakim, Mireille H. Lahoud, Kate E. Lawlor, Benjamin T. Kile, Meredith O’Keeffe, Dominic De Nardo
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110693- (2024)
Summary: The cGAS-STING pathway responds to cytosolic DNA to elicit host immunity to infection. The activation of stimulator of interferon genes (STING) can trigger a number of critical cellular responses including inflammation, noncanonical autophag
Externí odkaz:
https://doaj.org/article/4f6ffb7d172c46ffbb14376dc21aae1e
Autor:
Christophe Macri, Matthew Paxman, Devi Jenika, Xiao Peng Lin, Zahra Elahi, Paul A. Gleeson, Irina Caminschi, Mireille H. Lahoud, Jose A. Villadangos, Justine D. Mintern
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-12 (2024)
Abstract Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to specific DC subsets. The neonatal Fc receptor (FcRn) is a non-classical Fc receptor that bi
Externí odkaz:
https://doaj.org/article/52c49ac6819c466499f29a3bc9350bfe
Autor:
Mitra Ashayeripanah, Javier Vega-Ramos, Daniel Fernandez-Ruiz, Shirin Valikhani, Aaron T.L. Lun, Jason T. White, Louise J. Young, Atefeh Yaftiyan, Yifan Zhan, Linda Wakim, Irina Caminschi, Mireille H. Lahoud, Andrew M. Lew, Ken Shortman, Gordon K. Smyth, William R. Heath, Justine D. Mintern, Antoine Roquilly, Jose A. Villadangos
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113754- (2024)
Summary: Blood-borne pathogens can cause systemic inflammatory response syndrome (SIRS) followed by protracted, potentially lethal immunosuppression. The mechanisms responsible for impaired immunity post-SIRS remain unclear. We show that SIRS trigger
Externí odkaz:
https://doaj.org/article/531a91054c1e4bb68aeda10b35050804
Autor:
Runqiu Song, Mariam Bafit, Kirsteen M. Tullett, Peck Szee Tan, Mireille H. Lahoud, Meredith O’Keeffe, Anthony W. Purcell, Asolina Braun
Publikováno v:
Methods and Protocols, Vol 7, Iss 2, p 20 (2024)
The generation of bone-marrow-derived dendritic cells is a widely used approach in immunological research to study antigen processing and presentation, as well as T-cell activation responses. However, the initial step of isolating the bone marrow can
Externí odkaz:
https://doaj.org/article/542cc4b101824deaaea3f74857518e9f
Autor:
Haiyin Liu, Kayla R. Wilson, Ashley M. Firth, Christophe Macri, Patrick Schriek, Annabelle B. Blum, Javiera Villar, Samuel Wormald, Mitch Shambrook, Bangyan Xu, Hui Jing Lim, Hamish E. G. McWilliam, Andrew F. Hill, Laura E. Edgington-Mitchell, Irina Caminschi, Mireille H. Lahoud, Elodie Segura, Marco J. Herold, Jose A. Villadangos, Justine D. Mintern
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Regulated trafficking of major histocompatibility complex class II and CD86 is a prerequisite of antigen presenting cell functionality. Authors show here that ubiquitin-like protein 3 is critically involved in the ubiquitination process that controls
Externí odkaz:
https://doaj.org/article/e0c1150585254283885c639c972afad3
Autor:
Matthias H. Enders, Ganchimeg Bayarsaikhan, Sonia Ghilas, Yu Cheng Chua, Rose May, Maria N. de Menezes, Zhengyu Ge, Peck Szee Tan, Anton Cozijnsen, Vanessa Mollard, Katsuyuki Yui, Geoffrey I. McFadden, Mireille H. Lahoud, Irina Caminschi, Anthony W. Purcell, Ralf B. Schittenhelm, Lynette Beattie, William R. Heath, Daniel Fernandez-Ruiz
Publikováno v:
Current Research in Immunology, Vol 2, Iss , Pp 79-92 (2021)
Thorough understanding of the role of CD4 T cells in immunity can be greatly assisted by the study of responses to defined specificities. This requires knowledge of Plasmodium-derived immunogenic epitopes, of which only a few have been identified, es
Externí odkaz:
https://doaj.org/article/ae70f072848a4eb3bfa16dbb9ca365ca
Autor:
Hayley A. McNamara, Mireille H. Lahoud, Yeping Cai, Jessica Durrant-Whyte, James H. O’Connor, Irina Caminschi, Ian A. Cockburn
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Upon encountering cognate antigen, B cells can differentiate into short-lived plasmablasts, early memory B cells or germinal center B cells. The factors that determine this fate decision are unclear. Past studies have addressed the role of B cell rec
Externí odkaz:
https://doaj.org/article/aa11f575e13d4bf1b19c06aeac5d47e7
Autor:
Guillaume Paré, Julien Vitry, Michael L. Merchant, Myriam Vaillancourt, Andréa Murru, Yunyun Shen, Sabine Elowe, Mireille H. Lahoud, Paul H. Naccache, Kenneth R. McLeish, Maria J. Fernandes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The myeloid inhibitory C-type lectin receptor CLEC12A limits neutrophil activation, pro-inflammatory pathways and disease in mouse models of inflammatory arthritis by a molecular mechanism that remains poorly understood. We addressed how CLEC12A-medi
Externí odkaz:
https://doaj.org/article/1f3c2a23cdff4a229abc11afc23913e5
Autor:
Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, Marnie E Blewitt, William R Heath, Ken Shortman, Anthony W Purcell, Nicos A Nicola, Jian-Guo Zhang, Mireille H Lahoud
Publikováno v:
eLife, Vol 9 (2020)
The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8+ T cell immune responses. Here, we show that this process is regulated by E3 ubiquitin ligase RNF41 and
Externí odkaz:
https://doaj.org/article/ce7301ac4e2c47ffba46b495f1882e5b
Autor:
Oscar L Haigh, Kirsteen M Tullett, Carina Walpole, Jonathon Cebon, Christopher Schmidt, Liam O'Brien, Nikita Rosendahl, Ghazal Daraj, Irina Caminschi, Eric H Gschweng, Roger P Hollis, Donald B Kohn, Mireille H Lahoud
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Dendritic cells (DCs) are crucial for the efficacy of cancer vaccines, but current vaccines do not harness the key cDC1 subtype required for effective CD8+ T-cell-mediated tumor immune responses. Vaccine immunogenicity could be enhanced by
Externí odkaz:
https://doaj.org/article/11cf9f6bcce340f58753253d7529688c