Spastin regulates ER-mitochondrial contact sites and mitochondrial homeostasis

Autor: Amelie Raby, Sonia Missiroli, Peggy Sanatine, Dominique Langui, Julien Pansiot, Nissai Beaude, Lucie Vezzana, Rachelle Saleh, Martina Marinello, Mireille Laforge, Paolo Pinton, Ana Buj-Bello, Andrea Burgo

Publikováno v: iScience, Vol 27, Iss 9, Pp 110683- (2024)

Summary: Mitochondria-endoplasmic reticulum (ER) contact sites (MERCs) emerged to play critical roles in numerous cellular processes, and their dysregulation has been associated to neurodegenerative disorders. Mutations in the SPG4 gene coding for sp

Externí odkaz: https://doaj.org/article/7c8d77dc77d541b690d64de75d52c7d1

Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

Autor: Laura Le Pelletier, Matthieu Mantecon, Jennifer Gorwood, Martine Auclair, Roberta Foresti, Roberto Motterlini, Mireille Laforge, Michael Atlan, Bruno Fève, Jacqueline Capeau, Claire Lagathu, Veronique Bereziat

Publikováno v: eLife, Vol 10 (2021)

Aging is associated with central fat redistribution and insulin resistance. To identify age-related adipose features, we evaluated the senescence and adipogenic potential of adipose-derived stromal cells (ASCs) from abdominal subcutaneous fat obtaine

Externí odkaz: https://doaj.org/article/6426a1846c5b47f480f27f4a3ce2239c

Translocator Protein-Mediated Stabilization of Mitochondrial Architecture during Inflammation Stress in Colonic Cells.

Autor: Leeyah Issop, Mariano A Ostuni, Sunghoon Lee, Mireille Laforge, Gabriel Péranzi, Pierre Rustin, Jean-François Benoist, Jérome Estaquier, Vassilios Papadopoulos, Jean-Jacques Lacapère

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0152919 (2016)

UNLABELLED:Chronic inflammation of the gastrointestinal tract increasing the risk of cancer has been described to be linked to the high expression of the mitochondrial translocator protein (18 kDa; TSPO). Accordingly, TSPO drug ligands have been show

Externí odkaz: https://doaj.org/article/664bf669013d4244b481a8ec31acb30a

Antileishmanial Drugs Modulate IL-12 Expression and Inflammasome Activation in Primary Human Cells

Autor: Jérôme Estaquier, Sonia André, Jane MacDougall, Anabela Cordeiro-da-Silva, Mireille Laforge, Sarah Pemberton, Yasmina Fortier, Vasco Rodrigues

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2020, 204 (7), pp.1869-1880. ⟨10.4049/jimmunol.1900590⟩

Leishmaniases are neglected tropical diseases. The treatment of leishmaniasis relies exclusively on chemotherapy including amphotericin B (AmB), miltefosine (hexadecylphosphocholine), and pentamidine. Besides the fact that these molecules are harmful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4daca5e4ccf8b35e0def7ed0f469bba7
https://doi.org/10.4049/jimmunol.1900590

Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques.

Autor: Félicien Moukambi, Henintsoa Rabezanahary, Vasco Rodrigues, Gina Racine, Lynda Robitaille, Bernard Krust, Guadalupe Andreani, Calayselvy Soundaramourty, Ricardo Silvestre, Mireille Laforge, Jérôme Estaquier

Publikováno v: PLoS Pathogens, Vol 11, Iss 12, p e1005287 (2015)

Follicular T helper cells (Tfh), a subset of CD4 T lymphocytes, provide crucial help to B cells in the production of antigen-specific antibodies. Although several studies have analyzed the dynamics of Tfh cells in peripheral blood and lymph nodes (LN

Externí odkaz: https://doaj.org/article/02cb8889eb034f64b27ad3d64662f078