Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mireille, Giner"'
Autor:
Frank Lezoualc'h, Céline Rivière, Jean-Louis Soulier, Jean-Pierre Monti, Olivier Russo, Sames Sicsic, Marthe Cachard-Chastel, Isabelle Berque-Bestel, Tristan Richard, Mireille Giner, Magali Berthouze
Publikováno v:
Journal of Medicinal Chemistry. 52:2214-2225
Serotonin 5-HT(4) receptor (5-HT(4)R) agonists are of particular interest for the treatment of Alzheimer's disease because of their ability to ameliorate cognitive deficits and to modulate production of amyloid beta-protein (Abeta). However, despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f92df50bc84ffa6d24be4d7e4425ed
https://doi.org/10.1021/jm801327q
https://doi.org/10.1021/jm801327q
Autor:
Lucie Rivail, Bernard Maigret, Mireille Giner, Monique Gastineau, Isabelle Berque-Bestel, Frank Lezoualc'h, Sames Sicsic, Magali Berthouze, Rodolphe Fischmeister, Jean-Louis Soulier
Publikováno v:
British Journal of Pharmacology. 143:361-370
A body of evidences suggests that a hydrophobic pocket of the human 5-HT4 receptor contributes to the high affinity of some bulky 5-HT4 ligands. A thorough study of this pocket was performed using mutagenesis and molecular modeling. Ligand binding or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db6caed5b198b1ab0daf29235e59f0a
https://doi.org/10.1038/sj.bjp.0705950
https://doi.org/10.1038/sj.bjp.0705950
Publikováno v:
Leukemia Research. 25:487-492
Changes in beta1-integrin expression have been involved in abnormal cellular interactions between malignant lymphocytes from Sézary (Sz) patients and keratinocytes. In this paper, we compare the activity of both distal and proximal promoters of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af246a54bb4520d25a68da4caa092e3
https://doi.org/10.1016/s0145-2126(00)00149-1
https://doi.org/10.1016/s0145-2126(00)00149-1
Autor:
Ivan Zahradnik, Mireille Giner, Michel Langlois, Sames Sicsic, Isabelle Berque-Bestel, Jeanne Mialet, Jean-Louis Soulier, Rodolphe Fischmeister, Frank Lezoualc'h, Sophie Curtet, Patrick Donzeau-Gouge
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, 2000, 43 (20), pp.3761-3769. ⟨10.1021/jm0009538⟩
Journal of Medicinal Chemistry, 2000, 43 (20), pp.3761-3769. ⟨10.1021/jm0009538⟩
International audience; New derivatives of arylpiperazine 9 were designed from ML 10302, a potent 5-HT 4 receptor agonist in the gastrointestinal system. Compounds were synthesized by condensation of a number of available arylpiperazines or heteroary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e623e3fa2d26bb562759e326bd87db
https://doi.org/10.1021/jm0009538
https://doi.org/10.1021/jm0009538
Autor:
Monique Gastineau, Rodolphe Fischmeister, Patrick Donzeau-Gouge, Mireille Giner, Yamina Dahmoune, Johan Hoebeke, Pierre Eftekhari, Michel Langlois, Isabelle Berque-Bestel, Frank Lezoualc'h, Jeanne Mialet, Sames Sicsic
Publikováno v:
British Journal of Pharmacology. 129:771-781
RT–PCR technique was used to clone the human 5-HT4(e) receptor (h5-HT4(e)) from heart atrium. We showed that this h5-HT4(e) receptor splice variant is restricted to brain and heart atrium. Recombinant h5-HT4(e) receptor was stably expressed in CHO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ded86e23aadf48480158fab635fe8134
https://doi.org/10.1038/sj.bjp.0703101
https://doi.org/10.1038/sj.bjp.0703101
Autor:
Jacqueline Pichon, Josiane Wantyghem, Malika Boukhelifa, J. Font, Michèle Aubery, F. Braut-Boucher, Mireille Giner, Yolene Paulin
Publikováno v:
Journal of Investigative Dermatology. 111(4):650-655
Data from the literature indicate that ICAM-1 molecules play an important role in keratinocyte interactions with lymphocytes via the lymphocyte function-associated-1 lymphocyte-adhesion molecule. We examined the role of beta1 integrins in keratinocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2aa002ef67b9e6cd486629ce1c51f0
Autor:
Michèle Aubery, Jacqueline Font, J. Wantyghem, Mireille Giner, M. P. Muriel, F. Braut-Boucher, J. Pichon
Publikováno v:
Toxicology in Vitro. 11:601-611
To assess the molecular and cellular events that occur in the skin during biological and pharmaco-toxicological processes, we developed different in vitro models. Two major systems are described: (1) relatively simple ones such as normal human kerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fa63b626d9f67f456618af63d21910
https://doi.org/10.1016/s0887-2333(97)00067-2
https://doi.org/10.1016/s0887-2333(97)00067-2
Autor:
Mireille Giner, Sames Sicsic, Isabelle Berque-Bestel, Olivier Russo, Magali Berthouze, Jean-Louis Soulier, Frank Lezoualc'h, Ralf Jockers, Lucie Rivail
Publikováno v:
Journal of medicinal chemistry. 50(18)
G-protein-coupled receptor dimerization directs the design of new drugs that specifically bind to receptor dimers. Here, we generated a targeted series of homobivalent ligands for serotonin 5-HT(4) receptor (5-HT(4)R) dimers composed of two 5-HT(4)R-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7444a10a2871aa88423bf05fc4765ca
https://pubmed.ncbi.nlm.nih.gov/17676726
https://pubmed.ncbi.nlm.nih.gov/17676726
Autor:
Bernard Maigret, Sames Sicsic, Lucie Rivail, Sandrine Ongeri, Frank Lezoualc'h, Rodolphe Fischmeister, Jean-Louis Soulier, Magali Berthouze, Olivier Russo, Isabelle Berque-Bestel, Mireille Giner
Publikováno v:
Journal of medicinal chemistry. 48(20)
Recently, human 5-HT4 receptors have been demonstrated to form constitutive dimers in living cells. To evaluate the role of dimerization on the 5-HT4 receptor function, we investigated the conception and the synthesis of bivalent molecules able to in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5439429336236532be0ead8ef302a855
https://pubmed.ncbi.nlm.nih.gov/16190749
https://pubmed.ncbi.nlm.nih.gov/16190749
Autor:
Lucie, Rivail, Mireille, Giner, Monique, Gastineau, Magali, Berthouze, Jean-Louis, Soulier, Rodolphe, Fischmeister, Frank, Lezoualc'h, Bernard, Maigret, Sames, Sicsic, Isabelle, Berque-Bestel
Publikováno v:
British journal of pharmacology. 143(3)
A body of evidences suggests that a hydrophobic pocket of the human 5-HT(4) receptor contributes to the high affinity of some bulky 5-HT(4) ligands. A thorough study of this pocket was performed using mutagenesis and molecular modeling. Ligand bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4768765bd9c83b780ad109b96a9114e
https://pubmed.ncbi.nlm.nih.gov/15351779
https://pubmed.ncbi.nlm.nih.gov/15351779