Zobrazeno 1 - 10 of 38 pro vyhledávání: '"Mireia Rodriguez-Zubiri"'
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Development of a continuous flow synthesis of FGIN-1-27 enabled by in-line 19F NMR analyses and optimization algorithms
Autor: Daniel Cortés-Borda, Elvina Barré, Ehu Camille Aka, Mireia Rodriguez-Zubiri, Eric Wimmer, Jonathan Farjon, N. Vasudevan, François-Xavier Felpin, Patrick Giraudeau
Publikováno v: Reaction Chemistry & Engineering. 6:1983-1992
A straightforward continuous flow synthesis of FGIN-1-27, a compound with potent anxiolytic effects, is described from inexpensive and commercially available starting materials. The four-step synthesis includes the direct C–H arylation of an indole
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b63a4dd87cc812189bf866bcf243cf6
https://doi.org/10.1039/d1re00220a
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3
Direct C−H Arylation of Indole‐3‐Acetic Acid Derivatives Enabled by an Autonomous Self‐Optimizing Flow Reactor
Autor: Eric Wimmer, N. Vasudevan, Daniel Cortés-Borda, Mireia Rodriguez-Zubiri, François-Xavier Felpin, Elvina Barré
Publikováno v: Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2021, 363 (3), pp.791-799. ⟨10.1002/adsc.202001217⟩
International audience; Described herein is a continuous‐flow strategy for the palladium‐catalyzed direct C−H arylation of indole‐3‐acetic acid derivatives with arenediazonium salts. A fully autonomous self‐optimizing flow platform was us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cbac4c321049833102b12f042fd1ca
https://hal.archives-ouvertes.fr/hal-03143311/file/AdvSynthCatal2021_Manuscript-Felpin-11112020.pdf
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4
Merging Gradient-Based Methods to Improve Benchtop NMR Spectroscopy: A New Tool for Flow Reaction Optimization
Autor: François-Xavier Felpin, Shrikant Kunjir, Vincent Coeffard, Mireia Rodriguez-Zubiri, Patrick Giraudeau, Jonathan Farjon
Publikováno v: HAL
ChemPhysChem
ChemPhysChem, Wiley-VCH Verlag, 2020
ChemPhysChem, Wiley-VCH Verlag, 2020, 21 (20), pp.2311-2319. ⟨10.1002/cphc.202000573⟩
International audience; Emerging low cost, compact NMR spectrometers that can be connected in-line to a flow reactor are suited to study reaction mixtures. The main limitation of such spectrometers arises from their lower magnetic field inducing a re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933759471ff746f8b336aeac6c982049
https://pubmed.ncbi.nlm.nih.gov/32955173
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5
Comparing Gas–Liquid Segmented and Tube-in-Tube Setups for the Aerobic Dimerization of Desmethoxycarpacine with an Automated Flow Platform
Autor: Elvina Barré, Lynda Ekou, Mireia Rodriguez-Zubiri, Ehu Camille Aka, François-Xavier Felpin, Daniel Cortés-Borda, Eric Wimmer, Tchirioua Ekou
Publikováno v: Organic Process Research and Development
Organic Process Research and Development, American Chemical Society, 2020, 24 (5), pp.745-751. ⟨10.1021/acs.oprd.9b00525⟩
The hazardous nature of molecular oxygen can be mitigated with the use of flow reactors of small size, which in turn accelerate the gas-to-liquid mass transfer rate. In this contribution, we describe a reconfigurable automated flow platform integrati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::803eea9bf7ed00c3d89fcb9d3337aafa
https://hal.archives-ouvertes.fr/hal-03003776/file/Manuscript-Felpin-10012020.pdf
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6
Reconfigurable Flow Platform for Automated Reagent Screening and Autonomous Optimization for Bioinspired Lignans Synthesis
Autor: Eric Wimmer, Daniel Cortés-Borda, François-Xavier Felpin, N. Vasudevan, Elvina Barré, Tchirioua Ekou, Mireia Rodriguez-Zubiri, Ehu Camille Aka, Lynda Ekou
Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2019, 84 (21), pp.14101-14112. ⟨10.1021/acs.joc.9b02263⟩
International audience; Naturally occurring benzoxanthenones, which belong to the vast family of lignans, are promising biologically relevant targets. They are biosynthetically produced by the oxidative dimerization of 2-propenyl phenols. In this man
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15abe24f47c49465682d2b7e2c696624
https://hal.archives-ouvertes.fr/hal-02371113
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7
Optimizing the Heck–Matsuda Reaction in Flow with a Constraint-Adapted Direct Search Algorithm
Autor: Marina E. Trusova, Françoise Zammattio, François-Xavier Felpin, Daniel Cortés-Borda, Mireia Rodriguez-Zubiri, Corentin Jamet, Charlotte Truchet, Ksenia Kutonova
Publikováno v: Organic Process Research and Development
Organic Process Research and Development, American Chemical Society, 2016, 20 (11), pp.1979-1987. ⟨10.1021/acs.oprd.6b00310⟩
International audience; The optimization of a palladium-catalyzed Heck Matsuda reaction using an optimization algorithm is presented. We modified and implemented the Nelder-Mead method in order to perform constrained optimizations in a multidimension
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fa740d558f129d5ca4c24c97331165
https://doi.org/10.1021/acs.oprd.6b00310
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8
Ultrafast 2D NMR on a benchtop spectrometer: Applications and perspectives
Autor: François-Xavier Felpin, Benoît Charrier, Serge Akoka, Patrick Giraudeau, Boris Gouilleux, Mireia Rodriguez-Zubiri
Publikováno v: Trends in Analytical Chemistry
Trends in Analytical Chemistry, Elsevier, 2016, 83, pp.65-75. ⟨10.1016/j.trac.2016.01.014⟩
Benchtop NMR spectrometers are associated with significant resolution losses, as peak overlaps become ubiquitous at low field. 2D spectroscopy offers an appealing solution to this issue. However 2D NMR is associated with long experimental times which
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44123a3fd1f074d3b3ec233923f74eb
https://doi.org/10.1016/j.trac.2016.01.014
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9
Ultra-fast Suzuki and Heck reactions for the synthesis of styrenes and stilbenes using arenediazonium salts as super-electrophiles
Autor: François-Xavier Felpin, Mireia Rodriguez-Zubiri, Nicole Jung, Pavel S. Postnikov, Stefan Bräse, Ksenia Kutonova, Marina E. Trusova
Publikováno v: Organic Chemistry Frontiers
Organic Chemistry Frontiers, Royal Society of Chemistry, 2018, 5 (1), pp.41-45. ⟨10.1039/c7qo00750g⟩
International audience; The super-electrophilic properties of arenediazonium salts have been exploited for achieving ultra-fast palladium-catalyzed coupling reactions with turnover frequencies up to 16 200 h(-1). These ultra-fast coupling reactions h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb4317b0d0aa1a668ed2ece926511be
https://hal.archives-ouvertes.fr/hal-02141027/document
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10
Real-time reaction monitoring by ultrafast 2D NMR on a benchtop spectrometer
Autor: Benoît Charrier, Mireia Rodriguez-Zubiri, Patrick Giraudeau, Jean-Nicolas Dumez, Boris Gouilleux, François-Xavier Felpin, Ernesto Danieli, Serge Akoka
Publikováno v: Analyst
Analyst, Royal Society of Chemistry, 2015, 140 (23), pp.7854-7858. ⟨10.1039/c5an01998b⟩
International audience; Reaction monitoring is widely used to follow chemical processes in a broad range of application fields. Recently, the development of robust benchtop NMR spectrometers has brought NMR under the fume hood, making it possible to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7c1e1149679b8798ac5f058a337575
https://doi.org/10.1039/c5an01998b
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