Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mireia Pastó"'
Autor:
Claudia Cavarischia, Lavinia Silvestri, Mireia Pastó, Marta Écija, Alex Comely, Tommaso Iacoangeli, Guido Furlotti
Publikováno v:
Synthesis. 52:2828-2832
Calcium acamprosate (Campral, N-acetylhomotaurine calcium salt) is a well-established drug for the treatment of alcohol dependence. Its preparation is generally based on a three-step process with some remarkable drawbacks. To avoid these flaws, we ha
Publikováno v:
Tetrahedron: Asymmetry. 17:151-160
Highly modular tridentate Schiff base ligands arising from enantiopure epoxyalcohols have been prepared and evaluated in catalysis using parallel methods. The key structural motifs and experimental parameters have been identified, allowing enantiosel
Publikováno v:
Tetrahedron: Asymmetry. 14:1747-1752
A family of enantiomerically pure ligands based on the cyclobutenedione structure, and containing either an enantiomerically pure amino alcohol or a diamine as the chiral element, has been synthesized. As first examples of their application, these ve
Publikováno v:
Tetrahedron Letters. 40:4977-4980
Double lithiation of bis(tetra-hydroindenyl)iron followed by phosphorylation using Ph 2 PCl affords two different chiral diphosphines having respectively C 1 - and C 2 -symmetry. Following antipode separation, the compounds can be used as ligands in
Publikováno v:
Tetrahedron Letters. 39:1233-1236
Highly enantioenriched cis and trans N-Boc-2,2-dimethyl-oxazolidine-5-carbaldehydes have been efficiently prepared from N-Boc-3-amino-1,2-alkanediols, readily available in enantiopure or enantioenriched form by Sharpless epoxidation methodology. Thes
Publikováno v:
Chem. Commun.. :1327-1329
Cyclocondensation reactions of aminoalcohols and with racemic or prochiral delta-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantio
Publikováno v:
Tetrahedron: Asymmetry. 7:243-262
Both anti- and syn-α-hydroxy-β-amino acids are efficiently synthesized in protected form and high enantiomeric purity from readily available anti-N-Boc-1-tert-butyldimethylsilyl-3-amino-1,2-diols. The preparation of the anti series is straightforwa
Publikováno v:
The Journal of Organic Chemistry. 61:6033-6037
Publikováno v:
Tetrahedron: Asymmetry. 6:2329-2342
An efficient enantioselective synthesis of fully protected anti 3-amino-2-hydroxybutyrates has been developed. Starting from enantiomerically enriched anti N-diphenylmethyl-3-amino-1,2-butanediol, after a change in the nitrogen protecting group, the
Publikováno v:
Tetrahedron Letters. 36:3019-3022
An efficient, stereodivergent and enantioselective synthesis of N-Boc-aminoalkyl epoxides has been developed. Starting from enantiomerically enriched anti N-diphenylmethyl-3-amino-1,2-diols, and after a change in the nitrogen protecting group, an int