Extracellular Release of Mitochondrial DNA: Triggered by Cigarette Smoke and Detected in COPD

Autor: Luca Giordano, Alyssa D. Gregory, Mireia Pérez Verdaguer, Sarah A. Ware, Hayley Harvey, Evan DeVallance, Tomasz Brzoska, Prithu Sundd, Yingze Zhang, Frank C. Sciurba, Steven D. Shapiro, Brett A. Kaufman

Publikováno v: Cells, Vol 11, Iss 3, p 369 (2022)

Cigarette smoke (CS) is the most common risk factor for chronic obstructive pulmonary disease (COPD). The present study aimed to elucidate whether mtDNA is released upon CS exposure and is detected in the plasma of former smokers affected by COPD as

Externí odkaz: https://doaj.org/article/750a2b2719a0434fb06e5f38c0023a63

Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex

Autor: Sara R. Roig, Mireia Pérez-Verdaguer, Daniel Sastre, Magalí Colomer-Molera, Michael M. Tamkun, Albert Vallejo-Gracia, Antonio Felipe, M. Pilar Lillo, Laura Solé

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Cells
Volume 9
Issue 5
Cells, Vol 9, Iss 1128, p 1128 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
instname

© 2020 by the authors.
The voltage-gated potassium channel Kv1.3 plays a crucial role during the immune response. The channel forms oligomeric complexes by associating with several modulatory subunits. KCNE4, one of the five members of the KCNE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512c2cbc6a61a7ee437d3f0f129df508
http://hdl.handle.net/10261/212524

Ubiquitination mediates Kv1.3 endocytosis as a mechanism for protein Kinase C-dependent modulation

Autor: Katarzyna Styrczewska, Mireia Pérez-Verdaguer, Alexander Sorkin, Albert Vallejo-Gracia, Ramón Martínez-Mármol, Antonio Felipe, Núria Comes

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports

The voltage-dependent potassium channel Kv1.3 plays essential physiological functions in the immune system. Kv1.3, regulating the membrane potential, facilitates downstream Ca2+ -dependent pathways and becomes concentrated in specific membrane microd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d205e1a19d5e97cf9cc8d607a5066473
http://hdl.handle.net/2445/120567

ERK1/2 Mediates EGF-Dependent Kv1.3 Endocytosis

Autor: Lluís Pujadas, Irene Estadella, Katarzyna Styrczewska, Mireia Pérez-Verdaguer, Eduardo Soriano, Antonio Felipe, Núria Comes, Ramón Martínez-Mármol, Alexander Sorkin

Publikováno v: Biophysical Journal. 112:251a-252a

The voltage-gated potassium channel Kv1.3 participates in immunity, axonal growth targeting, sensory discrimination, metabolism and insulin resistance. Kv1.3 regulation by phosphorylation has been extensively studied. EGF, via binding to the EGF rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ccb4776e720872a9466a7cbb81f5990c
https://doi.org/10.1016/j.bpj.2016.11.1374

The voltage-gated potassium channel Kv1.3 is a promising multitherapeutic target against human pathologies

Autor: Clara Serrano-Novillo, Antonio Felipe, Mireia Pérez-Verdaguer, Jesusa Capera, Daniel Sastre, Irene Estadella

Publikováno v: Expert opinion on therapeutic targets. 20(5)

The voltage-dependent potassium channel Kv1.3 is mainly present in the nervous and immune systems. In leukocytes, Kv1.3 fine-tunes the activation and proliferation of the immune response. However, Kv1.3 is also present in other tissues where its phys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf2c3b486e50f1be345aa0e213d7623
https://pubmed.ncbi.nlm.nih.gov/26634786