Výsledky vyhledávání - "Mireia Gómez-Angelats"

Pharmacological Characterization of Abediterol, a Novel Inhaled β2-Adrenoceptor Agonist with Long Duration of Action and a Favorable Safety Profile in Preclinical Models

Autor: Mireia Gómez-Angelats, Jordi Gras, Dolors Vilella, Amadeu Gavaldà, Marisa Viñals, Montserrat Miralpeix, Jorge Beleta, Esteban J. Morcillo, Hamish Ryder, Raquel Otal, Israel Ramos, Julio Cortijo, Jorge De Alba, Carla Carcasona, Carlos Puig, Mònica Aparici

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 342:497-509

Abediterol is a novel potent, long-acting inhaled β(2)-adrenoceptor agonist in development for the treatment of asthma and chronic obstructive pulmonary disease. Abediterol shows subnanomolar affinity for the human β(2)-adrenoceptor and a functiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a640102e2d09b4a5c973d0e4dfbe7bb0
https://doi.org/10.1124/jpet.112.193284

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Molecular evidence for the nuclear localization of FADD

Autor: John A. Cidlowski, Mireia Gómez-Angelats

Publikováno v: Cell Death & Differentiation. 10:791-797

The Fas-associated death domain (FADD) adaptor protein FADD/Mort-1 is recruited by several members of the tumor necrosis factor receptor (TNFR) superfamily during cell death activated via death receptors. Since most studies have focused on the intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfb85b95c2c0404b080c29aa1633fff
https://doi.org/10.1038/sj.cdd.4401237

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Invited Review: Cell Volume Control and Signal Transduction in Apoptosis

Autor: John A. Cidlowski, Mireia Gómez-Angelats

Publikováno v: Toxicologic Pathology. 30:541-551

Apoptosis is a physiological form of death in which cells turn-on an intrinsic genetic program that eventually leads to their destruction in a highly regulated manner. This process renders elimination of “unwanted cells” in the body, and accounts

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63ee5d6b0426d3677af0722977f8d261
https://doi.org/10.1080/01926230290105820

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Protein Kinase C Regulates FADD Recruitment and Death-inducing Signaling Complex Formation in Fas/CD95-induced Apoptosis

Autor: Mireia Gómez-Angelats, John A. Cidlowski

Publikováno v: Journal of Biological Chemistry. 276:44944-44952

Activation of protein kinase C (PKC) triggers cellular signals that inhibit Fas/CD95-induced cell death in Jurkat T-cells by poorly defined mechanisms. Previously, we have shown that one effect of PKC on Fas/CD95-dependent cell death occurs through i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb7461d6613e7451bc0835f81f6760a
https://doi.org/10.1074/jbc.m104919200

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Plasma Membrane Depolarization without Repolarization Is an Early Molecular Event in Anti-Fas-induced Apoptosis

Autor: Mireia Gómez-Angelats, John A. Cidlowski, Carl D. Bortner

Publikováno v: Journal of Biological Chemistry. 276:4304-4314

The movement of intracellular monovalent cations has previously been shown to play a critical role in events leading to the characteristics associated with apoptosis. A loss of intracellular potassium and sodium occurs during apoptotic cell shrinkage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b83c73b8c4020c428cc29b91c4f3406
https://doi.org/10.1074/jbc.m005171200

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Protein Kinase C (PKC) Inhibits Fas Receptor-induced Apoptosis through Modulation of the Loss of K+ and Cell Shrinkage

Autor: John A. Cidlowski, Mireia Gómez-Angelats, Carl D. Bortner

Publikováno v: Journal of Biological Chemistry. 275:19609-19619

Cell shrinkage and loss of intracellular K+ are early requisite features for the activation of effector caspases and apoptotic nucleases in Fas receptor-mediated apoptosis of Jurkat cells, although the mechanisms responsible for both process remain u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64088dafa865a99c1616049050dc8c2b
https://doi.org/10.1074/jbc.m909563199

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Discovery of substituted phenyl urea derivatives as novel long-acting β2-adrenoreceptor agonists

Autor: Maribel Crespo, Daniel I. Pérez, Montserrat Miralpeix, Laia Sole, Raquel Otal, Amadeu Gavaldà, Maria Prat, Elena Calama, Mireia Gómez-Angelats, Carles Puig, Carla Carcasona

Publikováno v: Bioorganicmedicinal chemistry letters. 21(5)

The synthesis of diverse functionalized ureas in a semi-parallel fashion is described, as well as their β(1)/β(2)-adrenergic activities and the corresponding structure-activity relationship (SAR). We have focused on lipophilicity and duration of ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11976633d1df9ac51915e5d31e60ce81
https://pubmed.ncbi.nlm.nih.gov/21277205

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