Molecular pathology, developmental changes and synaptic dysfunction in (pre-) symptomatic human C9ORF72-ALS/FTD cerebral organoids

Autor: Astrid T. van der Geest, Channa E. Jakobs, Tijana Ljubikj, Christiaan F. M. Huffels, Marta Cañizares Luna, Renata Vieira de Sá, Youri Adolfs, Marina de Wit, Daan H. Rutten, Marthe Kaal, Maria M. Zwartkruis, Mireia Carcolé, Ewout J. N. Groen, Elly M. Hol, Onur Basak, Adrian M. Isaacs, Henk-Jan Westeneng, Leonard H. van den Berg, Jan H. Veldink, Domino K. Schlegel, R. Jeroen Pasterkamp

Publikováno v: Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-31 (2024)

Abstract A hexanucleotide repeat expansion (HRE) in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Human brain imaging and experimental studies indicate early changes in brain struct

Externí odkaz: https://doaj.org/article/081ca424a8b945aa9f02a6c9589c4317

Blockade of the Sigma-1 Receptor Relieves Cognitive and Emotional Impairments Associated to Chronic Osteoarthritis Pain

Autor: Mireia Carcolé, Daniel Zamanillo, Manuel Merlos, Begoña Fernández-Pastor, David Cabañero, Rafael Maldonado

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Osteoarthritis is the most common musculoskeletal disease worldwide, often characterized by degradation of the articular cartilage, chronic joint pain and disability. Cognitive dysfunction, anxiety and depression are common comorbidities that impact

Externí odkaz: https://doaj.org/article/2c37017385bc4983814fd67aacab6c8b

Development of a sensitive trial-ready poly(GP) CSF biomarker assay for

Autor: Katherine M, Wilson, Eszter, Katona, Idoia, Glaria, Mireia, Carcolé, Imogen J, Swift, Aitana, Sogorb-Esteve, Carolin, Heller, Arabella, Bouzigues, Amanda J, Heslegrave, Ashvini, Keshavan, Kathryn, Knowles, Saurabh, Patil, Susovan, Mohapatra, Yuanjing, Liu, Jaya, Goyal, Raquel, Sanchez-Valle, Robert Jr, Laforce, Matthis, Synofzik, James B, Rowe, Elizabeth, Finger, Rik, Vandenberghe, Christopher R, Butler, Alexander, Gerhard, John C, Van Swieten, Harro, Seelaar, Barbara, Borroni, Daniela, Galimberti, Alexandre, de Mendonça, Mario, Masellis, M Carmela, Tartaglia, Markus, Otto, Caroline, Graff, Simon, Ducharme, Jonathan M, Schott, Andrea, Malaspina, Henrik, Zetterberg, Ramakrishna, Boyanapalli, Jonathan D, Rohrer, Adrian M, Isaacs, Miren, Zulaica

Publikováno v: Journal of neurology, neurosurgery, and psychiatry. 93(7)

A GGGGCC repeat expansion in theWe used the single molecule array (Simoa) platform to develop an immunoassay for measuring poly(GP) dipeptide repeat proteins (DPRs) generated by theWe show the assay to be highly sensitive and robust, passing extensiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::79bb98e10e36c5abc2fb0ed5ebeebce1
https://pubmed.ncbi.nlm.nih.gov/35379698

Blockade of the sigma-1 receptor relieves cognitive and emotional impairments associated to chronic osteoarthritis pain

Autor: David Cabañero, Mireia Carcolé, Daniel Zamanillo, Rafael Maldonado, Manuel Merlos, Begoña Fernández-Pastor

Publikováno v: Frontiers in Pharmacology
Recercat. Dipósit de la Recerca de Catalunya
instname
Frontiers in Pharmacology, Vol 10 (2019)

Osteoarthritis is the most common musculoskeletal disease worldwide, often characterized by degradation of the articular cartilage, chronic joint pain and disability. Cognitive dysfunction, anxiety and depression are common comorbidities that impact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55fa6a397c8822b78664849623829774
http://hdl.handle.net/10230/42253

The Induction of heme oxygenase 1 decreases painful diabetic neuropathy and enhances the antinociceptive effects of morphine in diabetic mice

Autor: Mireia Carcolé, Sergi Leánez, Olga Pol, Sílvia Castany

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0146427 (2016)
PLoS One
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

Painful diabetic neuropathy is a common complication of diabetes mellitus which is poorly controlled by conventional analgesics. This study investigates if treatment with an heme oxygenase 1 (HO-1) inducer, cobalt protoporphyrin IX (CoPP), could modu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd949ead758c188078f7a74bf0acee7
https://ddd.uab.cat/record/146736