Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mirco Glitscher"'
Autor:
Mirco Glitscher, Inga Mareike Spannaus, Fabiane Behr, Robin Oliver Murra, Kathrin Woytinek, Daniela Bender, Eberhard Hildt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 4, Pp 589-605 (2024)
Background: A peculiar feature of the hepatitis E virus (HEV) is its reliance on the exosomal route for viral release. Genomic replication is mediated via the viral polyprotein pORF1, yet little is known about its subcellular localization. Methods: S
Externí odkaz:
https://doaj.org/article/d7e61af89377460ca741b230e6b20336
Autor:
Daniela Bender, Alexandra Koulouri, Xingjian Wen, Mirco Glitscher, Anja Schollmeier, Liliana Fernandes da Costa, Robin Oliver Murra, Gert Paul Carra, Vanessa Haberger, Gerrit J K Praefcke, Eberhard Hildt
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011976 (2024)
Viral infections trigger the expression of interferons (IFNs) and interferon stimulated genes (ISGs), which are crucial to modulate an antiviral response. The human guanylate binding protein 1 (GBP1) is an ISG and exhibits antiviral activity against
Externí odkaz:
https://doaj.org/article/12db4dd436b9413394872c091c0e886f
Autor:
Qingyan Wu, Mirco Glitscher, Susanne Tonnemacher, Anja Schollmeier, Jan Raupach, Tobias Zahn, Regina Eberle, Jacomine Krijnse-Locker, Michael Basic, Eberhard Hildt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 1, Pp 237-259 (2023)
Background & Aims: Hepatitis B virus (HBV) was identified as an enveloped DNA virus with a diameter of 42 nm. Multivesicular bodies play a central role in HBV egress and exosome biogenesis. In light of this, it was studied whether intact virions wrap
Externí odkaz:
https://doaj.org/article/cdea57c472a2429dbc1ff347218eb19c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4964 (2023)
The hepatitis B virus (HBV) counts as a major global health problem, as it presents a significant causative factor for liver-related morbidity and mortality. The development of hepatocellular carcinomas (HCC) as a characteristic of a persistent, chro
Externí odkaz:
https://doaj.org/article/e30a55009b9540b19a24031d685ff900
Autor:
Mirco Glitscher, David Heiler Martín, Kathrin Woytinek, Benjamin Schmidt, Denna Tabari, Catharina Scholl, Julia C. Stingl, Evelyn Seelow, Mira Choi, Eberhard Hildt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 159-180 (2021)
Background and aims: The Hepatitis E virus hijacks the endosomal system for its release. These structures are highly dependent on cholesterol. Hence, this study investigates the impact of HEV on cholesterol-metabolism, the effect of intracellular cho
Externí odkaz:
https://doaj.org/article/2c82aa411d1e43f98ee6cfc17d95c727
Autor:
Mirco Glitscher, Eberhard Hildt
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Cholesterol has gained tremendous attention as an essential lipid in the life cycle of virtually all viruses. These seem to have developed manifold strategies to modulate the cholesterol metabolism to the side of lipid uptake and de novo synthesis. I
Externí odkaz:
https://doaj.org/article/95639d6952f842458c3da267067c6107
Autor:
Kai-Henrik Peiffer, Catrina Spengler, Michael Basic, Bingfu Jiang, Lisa Kuhnhenn, Wiebke Obermann, Tobias Zahn, Mirco Glitscher, Alessandro Loglio, Floriana Facchetti, Gert Carra, Alica Kubesch, Johannes Vermehren, Viola Knop, Christiana Graf, Julia Dietz, Fabian Finkelmeier, Eva Herrmann, Jonel Trebicka, Arnold Grünweller, Stefan Zeuzem, Christoph Sarrazin, Pietro Lampertico, Eberhard Hildt
Publikováno v:
JCI Insight, Vol 5, Iss 22 (2020)
Many mutation analyses of the HBV genome have been performed in the search for new prognostic markers. However, the Kozak sequence preceding precore was covered only infrequently in these analyses. In this study, the HBV core promoter/precore region
Externí odkaz:
https://doaj.org/article/ad965b77b3ad42bfb034cd0860b5610d
Autor:
Lisa Marie Kaiser, Mirja Harms, Daniel Sauter, Vijay P. S. Rawat, Mirco Glitscher, Eberhard Hildt, Daniel Tews, Zachary Hunter, Jan Münch, Christian Buske
Publikováno v:
Cancers, Vol 13, Iss 4, p 826 (2021)
CXCR4 expression and downstream signaling have been identified as key factors in malignant hematopoiesis. Thus, up to 40% of all patients with Waldenström’s macroglobulinemia (WM) carry an activating mutation of CXCR4 that leads to a more aggressi
Externí odkaz:
https://doaj.org/article/f34d45128f3d422eba08cc8ec17369d8
Autor:
Mirco Glitscher, Kiyoshi Himmelsbach, Kathrin Woytinek, Reimar Johne, Andreas Reuter, Jelena Spiric, Luisa Schwaben, Arnold Grünweller, Eberhard Hildt
Publikováno v:
Viruses, Vol 10, Iss 6, p 301 (2018)
Every year, there are about 20 Mio hepatitis E virus (HEV) infections and 60,000 deaths that are associated with HEV worldwide. At the present, there exists no specific therapy for HEV. The natural compound silvestrol has a potent antiviral effect ag
Externí odkaz:
https://doaj.org/article/d72cd70562524de0ac15c6d5a9ba7866
Publikováno v:
Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz, 65(2):228-237
Worldwide, the hepatitis B and hepatitis C viruses (HBV, HCV) are the most relevant causative viral agents of a chronic hepatitis (inflammation of the liver). At present, more than 250 million people suffer from a chronic HBV infection globally, resu