Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mirco Galié"'
Autor:
Cristina Andreani, Caterina Bartolacci, Giuseppe Persico, Francesca Casciaro, Stefano Amatori, Mirco Fanelli, Marco Giorgio, Mirco Galié, Daniele Tomassoni, Junbiao Wang, Xiaoting Zhang, Gregory Bick, Roberto Coppari, Cristina Marchini, Augusto Amici
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract The histone deacetylase sirtuin 6 (SIRT6) has been endowed with anti-cancer capabilities in many tumor types. Here, we investigate the impact of SIRT6-overexpression (SIRT6-OE) in Delta16HER2 mice, which are a bona fide model of HER2-positiv
Externí odkaz:
https://doaj.org/article/8139fbb56d614a27a117f5c1c6e0780d
Autor:
Rafael M. Ioris, Mirco Galié, Giorgio Ramadori, Jason G. Anderson, Anne Charollais, Georgia Konstantinidou, Xavier Brenachot, Ebru Aras, Algera Goga, Nicholas Ceglia, Carlos Sebastián, Denis Martinvalet, Raul Mostoslavsky, Pierre Baldi, Roberto Coppari
Publikováno v:
Cell Reports, Vol 18, Iss 8, Pp 1858-1868 (2017)
Cancer stem cells (CSCs) have high tumorigenic capacity. Here, we show that stem-like traits of specific human cancer cells are reduced by overexpression of the histone deacetylase sirtuin 6 (SIRT6). SIRT6-sensitive cancer cells bear mutations that a
Externí odkaz:
https://doaj.org/article/e7cf775d005b4cbea795b0e078e48453
Autor:
Ebru Aras, Giorgio Ramadori, Kenichiro Kinouchi, Yu Liu, Rafael M. Ioris, Xavier Brenachot, Sanda Ljubicic, Christelle Veyrat-Durebex, Silvia Mannucci, Mirco Galié, Pierre Baldi, Paolo Sassone-Corsi, Roberto Coppari
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2385-2398.e3 (2019)
Summary: Loss of synchrony between geophysical time and insulin action predisposes to metabolic diseases. Yet the brain and peripheral pathways linking proper insulin effect to diurnal changes in light-dark and feeding-fasting inputs are poorly under
Externí odkaz:
https://doaj.org/article/7bf84bd976e1468ca62e2d4016c78a01
ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 10, Pp 2402-2426 (2024)
Abstract Mutated KRAS serves as the oncogenic driver in 30% of non-small cell lung cancers (NSCLCs) and is associated with metastatic and therapy-resistant tumors. Focal Adhesion Kinase (FAK) acts as a mediator in sustaining KRAS-driven lung tumors,
Externí odkaz:
https://doaj.org/article/6d906eadefba4aea98f43f8cb1de0cbe
Autor:
Sylwia Dabrowska, Ermanna Turano, Ilaria Scambi, Federica Virla, Alice Nodari, Francesco Pezzini, Mirco Galiè, Bruno Bonetti, Raffaella Mariotti
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5707 (2024)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of upper and lower motor neurons (MNs) in the brain and spinal cord, leading to progressive paralysis and death. Increasing evidenc
Externí odkaz:
https://doaj.org/article/3299967ab1484a0ca9570015d7cf81b4
Autor:
Luigi Cerulo, Nunziana Pezzella, Francesca Pia Caruso, Paola Parente, Andrea Remo, Guido Giordano, Nicola Forte, Johan Busselez, Federico Boschi, Mirco Galiè, Brunella Franco, Massimo Pancione
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106602- (2023)
Summary: Ribonucleoprotein (RNP) condensates are crucial for controlling RNA metabolism and splicing events in animal cells. We used spatial proteomics and transcriptomic to elucidate RNP interaction networks at the centrosome, the main microtubule-o
Externí odkaz:
https://doaj.org/article/98c0da06e0e643cf9cfed81f62aa9753
Autor:
Ilaria Scambi, Daniele Peroni, Alice Nodari, Flavia Merigo, Donatella Benati, Federico Boschi, Silvia Mannucci, Andrea Frontini, Silvia Visonà, Andrea Sbarbati, Mauro Krampera, Mirco Galiè
Publikováno v:
European Journal of Cell Biology, Vol 101, Iss 2, Pp 151206- (2022)
Multipotent stem cells persist within the stromal vascular fraction (SVF) of adipose tissue during adulthood. These cells, commonly referred to as adipose-derived stromal cells (ASC), have been extensively investigated over the past years as a promis
Externí odkaz:
https://doaj.org/article/3b34431397ed449bbbc0753c382b390e
Autor:
Mirco Galiè
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Externí odkaz:
https://doaj.org/article/671bc50143c3445dbe3385fd214fade1
Autor:
Mirco Galiè
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Oncogenic activation of RAS isoforms leads tumor initiation and progression in many types of cancers and is gaining increasing interest as target for novel therapeutic strategies. In sharp contrast with other types of cancer, the importance of RAS in
Externí odkaz:
https://doaj.org/article/5d34e444572440a5b8bcc4db4d6b7218
Autor:
Barbara Cisterna, Manuela Costanzo, Maria Assunta Lacavalla, Mirco Galiè, Osvaldo Angelini, Gabriele Tabaracci, Manuela Malatesta
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 10133 (2021)
Oxygen–ozone (O2–O3) therapy is increasingly applied as a complementary/adjuvant treatment for several diseases; however, the biological mechanisms accounting for the efficacy of low O3 concentrations need further investigations to understand the
Externí odkaz:
https://doaj.org/article/1f5924b2aec84bc298b11a9bf1c7fdd0