Výsledky vyhledávání - "Mirco Fleige"

α-Unsubstituted Pyrroles by NHC-Catalyzed Three-Component Coupling: Direct Synthesis of a Versatile Atorvastatin Derivative

Autor: Mirco Fleige, Frank Glorius

Publikováno v: Chemistry - A European Journal. 23:10773-10776

A practical one-pot cascade reaction protocol provides direct access to valuable 1,2,4-trisubstituted pyrroles. The process involves an N-heterocyclic carbene (NHC)-catalyzed Stetter-type hydroformylation using glycolaldehyde dimer as a novel C1 buil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e35eb8ae81dbc2c3e0a34bb82b0c72e
https://doi.org/10.1002/chem.201703008

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Mechanistic Studies on a Cooperative NHC Organocatalysis/Palladium Catalysis System: Uncovering Significant Lessons for Mixed Chiral Pd(NHC)(PR3) Catalyst Design

Autor: Frank Glorius, Constantin G. Daniliuc, Chang Guo, Daniel Janssen-Müller, Mirco Fleige, Andreas Lerchen

Publikováno v: Journal of the American Chemical Society. 139:4443-4451

A comprehensive investigation of the mechanism of the highly enantioselective Pd(PPh3)4/NHC-catalyzed annulation of vinyl benzoxazinanones and enals has been conducted. A study of reaction orders supports the postulated cooperative catalysis. Interes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2175165d8d48515b22de314eef5efd89
https://doi.org/10.1021/jacs.7b00462

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NHC-Catalyzed Enantioselective Dearomatizing Hydroacylation of Benzofurans and Benzothiophenes for the Synthesis of Spirocycles

Autor: Danny Schlüns, Daniel Janssen-Müller, Constantin G. Daniliuc, Johannes Neugebauer, Marco Wollenburg, Frank Glorius, Mirco Fleige

Publikováno v: ACS Catalysis. 6:5735-5739

Benzofurans and benzothiophenes have been efficiently employed as substrates in an enantioselective intramolecular hydroacylation. Breaking aromaticity in a 5-exo-trig cyclization of easily accessible heteroarenes by NHC-catalyzed hydroacylation give

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f0902c2c7a33632aa3e917b1753d7ed
https://doi.org/10.1021/acscatal.6b01852

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Cooperative N-Heterocyclic Carbene/Palladium-Catalyzed Enantioselective Umpolung Annulations

Autor: Chang Guo, Mirco Fleige, Constantin G. Daniliuc, Daniel Janssen-Müller, Frank Glorius

Publikováno v: Journal of the American Chemical Society. 138:7840-7843

A combination of NHC organocatalysis and transition-metal catalysis gives rise to fundamentally new cooperative reactivity and enables the regio- and enantioselective annulation reaction between enals and vinyl benzoxazinanones. The cooperative umpol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d950e840e6b8169e3dd06963d5a6f1c
https://doi.org/10.1021/jacs.6b04364

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Light-active azaphenalene alkoxyamines: fast and efficient mediators of a photo-induced persistent radical effect

Autor: Kathryn E. Fairfull-Smith, James P. Blinco, Steven E. Bottle, Yohann Guillaneuf, Jean-Louis Clément, Mirco Fleige, Emily M. Simpson, Didier Gigmes

Publikováno v: RSC Advances. 6:80328-80333

Here we report the first example of an alkoxyamine derived from an azaphenalene nitroxide, which when exposed to UV-light, readily undergoes homolysis to efficiently and cleanly re-form a nitroxide. This process selectively cleaves the C–O bond of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8cfa8c57b9c034a551bdfece5c2e90ea
https://doi.org/10.1039/c6ra18500b

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Lewis acid catalysis: catalytic hydroboration of alkynes initiated by Piers' borane

Autor: Frank Glorius, Thorsten vom Stein, Douglas W. Stephan, Mirco Fleige, Juri Möbus

Publikováno v: Chemical Communications. 52:10830-10833

Terminal and internal alkynes are efficiently hydroborated to (E)-alkenyl pinacol boronic esters with excellent yields and selectivities using Piers' borane, (HB(C6F5)2) as a pre-catalyst for the dissymmetrically gem-diborylated catalyst of the form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c5cd4e35565a7fcfbd2d165ca479f4
https://doi.org/10.1039/c6cc05360b

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Switchable selectivity in an NHC-catalysed dearomatizing annulation reaction

Autor: Constantin G. Daniliuc, Mirco Fleige, Chang Guo, Daniel Janssen-Müller, Frank Glorius

Publikováno v: Nature Chemistry. 7:842-847

The development of general catalytic methods for the regio- and stereoselective construction of chiral N-heterocycles in a diversity-oriented fashion remains a formidable challenge in organic synthesis. N-heterocyclic carbene (NHC) catalysis has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee754cbc42c2ababc234077e43b33c99
https://doi.org/10.1038/nchem.2337

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