Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Autor: Sadiku, Pranvera, Willson, Joseph A., Ryan, Eilise M., Sammut, David, Coelho, Patricia, Watts, Emily R., Grecian, Robert, Young, Jason M., Bewley, Martin, Arienti, Simone, Mirchandani, Ananda S., Sanchez Garcia, Manuel A., Morrison, Tyler, Zhang, Ailing, Reyes, Leila, Griessler, Tobias, Jheeta, Privjyot, Paterson, Gordon G., Graham, Christopher J., Thomson, John P., Baillie, Kenneth, Thompson, A.A. Roger, Morgan, Jessie-May, Acosta-Sanchez, Abel, Dardé, Veronica M., Duran, Jordi, Guinovart, Joan J., Rodriguez-Blanco, Gio, Von Kriegsheim, Alex, Meehan, Richard R., Mazzone, Massimiliano, Dockrell, David H., Ghesquiere, Bart, Carmeliet, Peter, Whyte, Moira K.B., Walmsley, Sarah R.

Publikováno v: In Cell Metabolism 2 February 2021 33(2):411-423

A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS­­­

Autor: Reyes, Leila, Sanchez Garcia, Manuel Alejandro, Morrison, Tyler, Howden, Andrew J M, Watts, Emily R, Arienti, Simone, Sadiku, Pranvera, Coelho, Patricia, Mirchandani, Ananda S, Zhang, Ailiang, Hope, David, Clark , Sarah K, Singleton, Jo, Johnston, Shonna, Grecian, Rob, Poon, Azin S., McNamara, Sarah, Harper, Isla, Fourman, Max Head, Brenes, Alejandro J, Pathak, Shalini, Lloyd, Amy, Rodriguez Blanco, Gio, von Kriegsheim, Alexander, Ghesquiere, Bart, Vermaelen, Wesley, Cologna, Camilla T, Dhaliwal, Kevin, Hirani, Nik, Dockrell, David H, Whyte, Moira K B, Griffith, David M, Cantrell, Doreen, Walmsley, Sarah R

Publikováno v: Reyes, L, Sanchez Garcia, M A, Morrison, T, Howden, A J M, Watts, E R, Arienti, S, Sadiku, P, Coelho, P, Mirchandani, A S, Zhang, A, Hope, D, Clark, S K, Singleton, J, Johnston, S, Grecian, R, Poon, A S, McNamara, S, Harper, I, Fourman, M H, Brenes, A J, Pathak, S, Lloyd, A, Rodriguez Blanco, G, von Kriegsheim, A, Ghesquiere, B, Vermaelen, W, Cologna, C T, Dhaliwal, K, Hirani, N, Dockrell, D H, Whyte, M K B, Griffith, D M, Cantrell, D & Walmsley, S R 2021 ' A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS­­­ ' wellcome Open Research . https://doi.org/10.12688/wellcomeopenres.16584.2

Background: Acute respiratory distress syndrome (ARDS) is a severe critical condition with a high mortality that is currently in focus given that it is associated with mortality caused by coronavirus disease 2019 (COVID-19). Neutrophils play a key ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::0af2b9767a8fb588416da568c7dff4b5
https://www.pure.ed.ac.uk/ws/files/197041195/dc84475d_2d61_415e_95a2_2422a59c2804_16584_sarah_walmsley.pdf

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo

Autor: Harris, Alison J, Mirchandani, Ananda S, Lynch, Ruairi W, Delaney, Liam, Small, Donna, Coelho, Patricia, Watts, Emily R, Sadiku, Pranvera, Griffith, David, Dickinson, Rebecca S, Clark, Eilidh, Willson, Joseph A, Morrison, Tyler, Mazzone, Massimilliano, Carmeliet, Peter, Ghesquiere, Bart, O'Kane, Cecilia, McAuley, Danny, Jenkins, Steve J, Whyte, Moira K B, Walmsley, Sarah R

Publikováno v: Harris, A J, Mirchandani, A S, Lynch, R W, Delaney, L, Small, D, Coelho, P, Watts, E R, Sadiku, P, Griffith, D, Dickinson, R S, Clark, E, Willson, J A, Morrison, T, Mazzone, M, Carmeliet, P, Ghesquiere, B, O'Kane, C, McAuley, D, Jenkins, S J, Whyte, M K B & Walmsley, S R 2019, ' IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo ', American Journal of Respiratory and Critical Care Medicine, vol. 200, no. 2, pp. 235 . https://doi.org/10.1164/rccm.201808-1599OC

RATIONALE: Acute respiratory distress syndrome (ARDS) is defined by the presence of systemic hypoxia and consequent upon disordered neutrophilic inflammation. Local mechanisms limiting the duration and magnitude of this neutrophilic response remain p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2607::4af535eb4eadf014b72df707229fc039
https://pure.qub.ac.uk/en/publications/92af9b83-b088-4fff-8f95-bf8d59783eba