Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Miranda van Eck"'
Autor:
Menno Hoekstra, Miranda Van Eck
Publikováno v:
Atherosclerosis Plus, Vol 53, Iss , Pp 33-41 (2023)
Background and aims: Non-alcoholic fatty liver disease (NAFLD), a high incidence liver pathology, is associated with a ∼1.5-fold higher cardiovascular disease risk. This phenomenon is generally attributed to the NAFLD-associated increase in circula
Externí odkaz:
https://doaj.org/article/fa9a10c731fa48989ff35ce7d7468ae2
Autor:
Menno Hoekstra, Laura M. de Jong, Rick van der Geest, Lidewij R. de Leeuw, Rani Krisnamurthi, Janine J. Geerling, Miranda Van Eck
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 429 (2024)
Preclinical studies regarding the potential of liver X receptor (LXR) agonists to inhibit macrophage foam cell formation and the development of atherosclerotic lesions are generally executed in mice fed with Western-type diets enriched in cholesterol
Externí odkaz:
https://doaj.org/article/81278c42970048989268f38ff1cfb5fb
Autor:
Ronald J. van der Sluis, Tim van den Aardweg, Timothy J. P. Sijsenaar, Miranda Van Eck, Menno Hoekstra
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1287 (2023)
The steroid 11beta-hydroxylase inhibitor metyrapone is able to effectively reverse the hypercortisolemia detected in human Cushing’s Syndrome patients. In this current preclinical study, we investigated whether metyrapone monotherapy can also rever
Externí odkaz:
https://doaj.org/article/21c69ebc2045410995388d56d0e55659
Autor:
Laura M. de Jong, Zhengzheng Zhang, Yvette den Hartog, Timothy J. P. Sijsenaar, Renata Martins Cardoso, Martijn L. Manson, Thomas Hankemeier, Peter W. Lindenburg, Daniela C. F. Salvatori, Miranda Van Eck, Menno Hoekstra
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Protein arginine methyltransferase 3 (PRMT3) is a co-activator of liver X receptor capable of selectively modulating hepatic triglyceride synthesis. Here we investigated whether pharmacological PRMT3 inhibition can diminish the hepatic steat
Externí odkaz:
https://doaj.org/article/2acc68e974784fab8a54729f6409f243
Autor:
Menno Hoekstra, Baoyan Ren, Pirkka-Pekka Laurila, Reeni B. Hildebrand, Jarkko Soronen, Vanessa Frodermann, Zhuang Li, Mariëtte R. Boon, Janine J. Geerling, Patrick C. N. Rensen, Matti Jauhiainen, Miranda Van Eck
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Total body upstream stimulatory factor 1 (USF1) deficiency in mice is associated with brown adipose tissue activation and a marked protection against the development of obesity and atherosclerotic lesions. Functional expression of USF1 has a
Externí odkaz:
https://doaj.org/article/17a14d3adad549cc9cc447dc81e3bc71
Autor:
Josefien W. Hommes, Rachel M. Kratofil, Sigrid Wahlen, Carla J. C. de Haas, Reeni B. Hildebrand, G. Kees Hovingh, Micheal Otto, Miranda van Eck, Menno Hoekstra, Suzanne J. A. Korporaal, Bas G. J. Surewaard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Staphylococcus aureus virulence has been associated with the production of phenol-soluble modulins (PSMs). These PSMs have distinct virulence functions and are known to activate, attract and lyse neutrophils. These PSM-associated biological
Externí odkaz:
https://doaj.org/article/d79e59c52eb7439aaa4c53dd098bcdb8
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1205 (2022)
2-Hydroxypropyl-beta-cyclodextrin (2HPβCD) is able to bind and solubilize unesterified cholesterol and may therefore be able to reverse the deposition of cholesterol in macrophages within the aortic vessel wall, a hallmark of atherosclerotic cardiov
Externí odkaz:
https://doaj.org/article/26f82ccad1024aa2bcaa767b307d2eb0
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 9, p 110 (2021)
The genetic disorder Down syndrome is associated with a decreased susceptibility for atherosclerotic cardiovascular disease. Hematological and immune abnormalities occur frequently in Down syndrome patients. We evaluated, in a preclinical setting, th
Externí odkaz:
https://doaj.org/article/4a3ed1ce072a438499c8533aece40bec
Autor:
Menno Hoekstra, Miranda Van Eck
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 4, Pp 631-637 (2016)
The contribution of HDL to adrenal steroidogenesis appears to be different between mice and humans. In the current study, we tested the hypothesis that a difference in lipoprotein profile may be the underlying cause. Hereto, we determined the impact
Externí odkaz:
https://doaj.org/article/113ec7fb473541969ba60162910a6ed1
Autor:
Thomas Gautier, Willeke de Haan, Jacques Grober, Dan Ye, Matthias J. Bahr, Thierry Claudel, Niels Nijstad, Theo J.C. Van Berkel, Louis M. Havekes, Michael P. Manns, Stefan M. Willems, Pancras C.W. Hogendoorn, Laurent Lagrost, Folkert Kuipers, Miranda Van Eck, Patrick C.N. Rensen, Uwe J.F. Tietge
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 8, Pp 2195-2205 (2013)
Cholesteryl ester transfer protein (CETP) activity results in a proatherogenic lipoprotein profile. In cholestatic conditions, farnesoid X receptor (FXR) signaling by bile acids (BA) is activated and plasma HDL cholesterol (HDL-C) levels are low. Thi
Externí odkaz:
https://doaj.org/article/70b732072eac42ef9a7951d48e70bab0