Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Miranda Wang"'
Autor:
Musaddeque Ahmed, Fraser Soares, Ji-Han Xia, Yue Yang, Jing Li, Haiyang Guo, Peiran Su, Yijun Tian, Hyung Joo Lee, Miranda Wang, Nayeema Akhtar, Kathleen E. Houlahan, Almudena Bosch, Stanley Zhou, Parisa Mazrooei, Junjie T. Hua, Sujun Chen, Jessica Petricca, Yong Zeng, Alastair Davies, Michael Fraser, David A. Quigley, Felix Y. Feng, Paul C. Boutros, Mathieu Lupien, Amina Zoubeidi, Liang Wang, Martin J. Walsh, Ting Wang, Shancheng Ren, Gong-Hong Wei, Housheng Hansen He
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Prostate cancer risk-associated SNPs are enriched in noncoding CREs. Here the authors perform CRISPRi screens of CREs in prostate cancer cell lines to describe a causal mechanism synergistically driven by a risk SNP and DNA methylation-mediated 3D ge
Externí odkaz:
https://doaj.org/article/e7aa25730939461e8ebe506e7b821266
Autor:
Michael Zavortink, Lauren N Rutt, Svetlana Dzitoyeva, Jesslyn C Henriksen, Chloe Barrington, Danielle Y Bilodeau, Miranda Wang, Xiao Xiao Lily Chen, Olivia S Rissland
Publikováno v:
eLife, Vol 9 (2020)
The maternal-to-zygotic transition (MZT) is a conserved step in animal development, where control is passed from the maternal to the zygotic genome. Although the MZT is typically considered from its impact on the transcriptome, we previously found th
Externí odkaz:
https://doaj.org/article/d9c1b57f26f64ef38cdd74811f0c8152
Autor:
Olivia S. Rissland, Alexander O. Subtelny, Miranda Wang, Andrew Lugowski, Beth Nicholson, John D. Laver, Sachdev S. Sidhu, Craig A. Smibert, Howard D. Lipshitz, David P. Bartel
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background All mRNAs are bound in vivo by proteins to form mRNA–protein complexes (mRNPs), but changes in the composition of mRNPs during posttranscriptional regulation remain largely unexplored. Here, we have analyzed, on a transcriptome-
Externí odkaz:
https://doaj.org/article/d95ae799118d42feb5cbf376b05785f8
Autor:
Yong Zeng, Shiyan Wang, Shanshan Gao, Fraser Soares, Musadeqque Ahmed, Haiyang Guo, Miranda Wang, Junjie Tony Hua, Jiansheng Guan, Michael F Moran, Ming Sound Tsao, Housheng Hansen He
Publikováno v:
PLoS Biology, Vol 16, Iss 9, p e2006092 (2018)
N6-Methyladenosine (m6A) accounts for approximately 0.2% to 0.6% of all adenosine in mammalian mRNA, representing the most abundant internal mRNA modifications. m6A RNA immunoprecipitation followed by high-throughput sequencing (MeRIP-seq) is a power
Externí odkaz:
https://doaj.org/article/456757df71c4402bb693d41b4b5b2ef5
Autor:
Miranda Wang, Michael Ly, Andrew Lugowski, John D Laver, Howard D Lipshitz, Craig A Smibert, Olivia S Rissland
Publikováno v:
eLife, Vol 6 (2017)
In animal embryos, control of development is passed from exclusively maternal gene products to those encoded by the embryonic genome in a process referred to as the maternal-to-zygotic transition (MZT). We show that the RNA-binding protein, ME31B, bi
Externí odkaz:
https://doaj.org/article/eaede19c8aa14e899a9a1fb0f6b75940
Autor:
Almudena Bosch, Nayeema Akhtar, Miranda Wang, Yong Zeng, Amina Zoubeidi, Stanley Zhou, Yue Yang, Yijun Tian, Felix Y. Feng, Kathleen E. Houlahan, Shancheng Ren, Sujun Chen, Martin J. Walsh, Hyung Joo Lee, Gong-Hong Wei, Musaddeque Ahmed, Mathieu Lupien, Fraser Soares, Paul C. Boutros, David A. Quigley, Alastair H. Davies, Jing Li, Michael Fraser, Jessica Petricca, Liang Wang, Junjie Tony Hua, Parisa Mazrooei, Peiran Su, Haiyang Guo, Jihan Xia, Ting Wang, Housheng Hansen He
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Prostate cancer (PCa) risk-associated SNPs are enriched in noncoding cis-regulatory elements (rCREs), yet their modi operandi and clinical impact remain elusive. Here, we perform CRISPRi screens of 260 rCREs in PCa cell lines. We find that rCREs harb
Autor:
Diogo Teles, Luke Hao, Jinho Kim, Timothy Chen, Marcus Busub Lee, Alessandro Marturano-Kruik, Alan Chramiec, Keith Yeager, Daniel Naveed Tavakol, Joseph Pak, Gordana Vunjak-Novakovic, Kacey Ronaldson-Bouchard, Miranda Wang, Roberta Lock
Publikováno v:
Lab Chip
Traditional drug screening models are often unable to faithfully recapitulate human physiology in health and disease, motivating the development of microfluidic organs-on-a-chip (OOC) platforms that can mimic many aspects of human physiology and in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec58bdd55b187a2bc594bed0a016be3c
https://europepmc.org/articles/PMC8092329/
https://europepmc.org/articles/PMC8092329/
Autor:
Jesslyn C Henriksen, Michael Zavortink, Miranda Wang, Olivia S. Rissland, Svetlana Dzitoyeva, Lauren N Rutt, Chloe Barrington, Xiao Xiao Lily Chen, Danielle Y. Bilodeau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0da00839fb989b40d9df8584463794
https://doi.org/10.7554/elife.53889.sa2
https://doi.org/10.7554/elife.53889.sa2
Autor:
Svetlana Dzitoyeva, Michael Zavortink, Lauren N Rutt, Chloe Barrington, Olivia S. Rissland, Danielle Y. Bilodeau, Miranda Wang, Xiao Xiao Lily Chen
SUMMARYThe maternal-to-zygotic transition (MZT) is a conserved step in animal development, where control is passed from the maternal genome to the zygotic one. Although the MZT is typically considered from its impact on the transcriptome, we previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57d8e433ab4c7196bb3d5f7c0603d82
Publikováno v:
Evidence-Based Practice. 23:27-28