Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Miranda R M Baert"'
Autor:
Machteld M Tiemessen, Miranda R M Baert, Tom Schonewille, Martijn H Brugman, Farbod Famili, Daniela C F Salvatori, Jules P P Meijerink, Ugur Ozbek, Hans Clevers, Jacques J M van Dongen, Frank J T Staal
Publikováno v:
PLoS Biology, Vol 10, Iss 11, p e1001430 (2012)
The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1(-/-) mice have previously been characterized and show developmental blocks at the CD4-CD8- double negative (DN) to CD4+
Externí odkaz:
https://doaj.org/article/d01e65ab97f9410c99e8a9d22ab94577
Autor:
Sandra A. Vloemans, Karin Pike-Overzet, Erik B. van den Akker, Marja C.J.A. van Eggermond, Martijn Cordes, Marcel J. T. Reinders, Laura Garcia-Perez, Frank J. T. Staal, Miranda R. M. Baert
Publikováno v:
Bioinformatics
Bioinformatics, 36(6), 1930-1932. OXFORD UNIV PRESS
Bioinformatics, 36(6), 1930-1932. OXFORD UNIV PRESS
Summary An effective immune system is characterized by a diverse immune repertoire. There is a strong demand for accurate and quantitative methods to assess the diversity of the immune repertoire for various (pre-)clinical applications, including the
Autor:
Suzanne P. M. Welten, Machteld M. Tiemessen, Miranda R. M. Baert, Sandra A. Vloemans, Frank J. T. Staal, Anke Redeker, Ramon Arens
Publikováno v:
Journal of Immunology, 195(10), 4792-4801
Adequate responsiveness of CD8+ T cell populations is of utmost importance for the efficacy of many vaccines and immunotherapeutic strategies against intracellular pathogens and cancer. In this study, we show in mouse models that the relative number
Autor:
Mjt Reinders, Martijn H. Brugman, Adrian J. Thrasher, Gerard Wagemaker, Miranda R. M. Baert, Denise T. D. de Ridder, J J M van Dongen, Monique M.A. Verstegen, Frank Jakob Theodor Staal, Floor Weerkamp, Steven J. Howe, Karin Pike-Overzet
Publikováno v:
Leukemia, 21(4), 754-763. Nature Publishing Group
The occurrence of leukemia in a gene therapy trial for SCID-X1 has highlighted insertional mutagenesis as an adverse effect. Although retroviral integration near the T-cell acute lymphoblastic leukemia (T-ALL) oncogene LIM-only protein 2 (LMO2) appea
Autor:
Martijn H. Brugman, Willem A. Dik, Gerard Wagemaker, Edwin F. E. de Haas, Floor Weerkamp, Miranda R. M. Baert, Trudi P. Visser, Jacques J.M. van Dongen, Christianne J.M. de Groot, Frank J. T. Staal
Publikováno v:
Blood, 107(8), 3131-3137. American Society of Hematology
It is a longstanding question which bone marrow–derived cell seeds the thymus and to what level this cell is committed to the T-cell lineage. We sought to elucidate this issue by examining gene expression, lineage potential, and self-renewal capaci
Autor:
Floor Weerkamp, Marcel J. T. Reinders, Esther E. L. Koster, Jacques J.M. van Dongen, Anton W. Langerak, Willem A. Dik, Peter J. van der Spek, Miranda R. M. Baert, Dick de Ridder, Karin Pike-Overzet, Frank J. T. Staal, Edwin F. E. de Haas
Publikováno v:
Journal of Experimental Medicine, 201(11), 1715-1723. Rockefeller University Press
The Journal of Experimental Medicine
The Journal of Experimental Medicine
To gain more insight into initiation and regulation of T cell receptor (TCR) gene rearrangement during human T cell development, we analyzed TCR gene rearrangements by quantitative PCR analysis in nine consecutive T cell developmental stages, includi
Autor:
Miranda R. M. Baert, Edwin F. E. de Haas, Frank J. T. Staal, Mascha van Noort, Jacques J.M. van Dongen, Caroline M. M. van den Burg, Floor Weerkamp
Publikováno v:
The Journal of Immunology. 172:1099-1108
The thymus is seeded by very small numbers of progenitor cells that undergo massive proliferation before differentiation and rearrangement of TCR genes occurs. Various signals mediate proliferation and differentiation of these cells, including Wnt si
Autor:
Frank J. T. Staal, Peter J. van den Elsen, Machteld M. Tiemessen, Lianne Kok, Ramon Arens, Miranda R. M. Baert, Marja C.J.A. van Eggermond
Publikováno v:
Journal of Immunology, 193(11), 5480-5487. American Association of Immunologists
Tiemessen, M M, Baert, M R M, Kok, L, van Eggermond, M C J A, van den Elsen, P J, Arens, R & Staal, F J T 2014, ' T Cell Factor 1 Represses CD8+ Effector T Cell Formation and Function ', Journal of Immunology, vol. 193, no. 11, pp. 5480-5487 . https://doi.org/10.4049/jimmunol.1303417
Journal of Immunology, 193(11), 5480-5487
Tiemessen, M M, Baert, M R M, Kok, L, van Eggermond, M C J A, van den Elsen, P J, Arens, R & Staal, F J T 2014, ' T Cell Factor 1 Represses CD8+ Effector T Cell Formation and Function ', Journal of Immunology, vol. 193, no. 11, pp. 5480-5487 . https://doi.org/10.4049/jimmunol.1303417
Journal of Immunology, 193(11), 5480-5487
The Wnt-responsive transcription factor T cell factor 1 (Tcf1) is well known for its role in thymic T cell development and the formation of memory CD8+ T cells. However, its role in the initial phases of CD8+ T effector cell formation has remained un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99efcde80a4811fd5fb6de0c68efe7d
https://research.vumc.nl/en/publications/3c563ff3-3f4b-4381-a925-dfc23b2e0992
https://research.vumc.nl/en/publications/3c563ff3-3f4b-4381-a925-dfc23b2e0992
Autor:
Johan Garssen, Adri van Oudenaren, Andre Boonstra, Harry van Steeg, Pieter J. M. Leenen, Miranda R. M. Baert, Gijsbertus T. J. van der Horst, Jan H.J. Hoeijmakers, Huub F. J. Savelkoul
Publikováno v:
Journal of Investigative Dermatology, 117, 141-146. Nature Publishing Group
Ultraviolet B irradiation has serious consequences for cellular immunity and can suppress the rejection of skin tumors and the resistance to infectious diseases. DNA damage plays a crucial role in these immunomodulatory effects of ultraviolet B, as i
Autor:
Ugur Ozbek, Machteld M. Tiemessen, Martijn H. Brugman, Daniela C.F. Salvatori, Tom Schonewille, Farbod Famili, Hans Clevers, Jules P.P. Meijerink, Jacques J.M. van Dongen, Miranda R. M. Baert, Frank J. T. Staal
Publikováno v:
PLoS Biology, Vol 10, Iss 11, p e1001430 (2012)
PLoS Biology, 10(11). Public Library of Science
PLoS Biology
PLoS Biology, 10(11). Public Library of Science
PLoS Biology
Tcf1 is known to function as a transcriptional activator of Wnt-induced proliferation during T cell development in the thymus. Evidence for an additional contrasting role for Tcf1 as a T-cell specific tumor suppressor gene is now presented.
The
The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7d256a2b348b853784ba073c113c79
https://hdl.handle.net/1887/97649
https://hdl.handle.net/1887/97649