Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Miranda Nabben"'
Autor:
Fang Wang, Dietbert Neumann, Dimitris Kapsokalyvas, Martijn F. Hoes, Francesco Schianchi, Jan F. C. Glatz, Miranda Nabben, Joost J. F. P. Luiken
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8131 (2024)
Chronic lipid overconsumption, associated with the Western diet, causes excessive cardiac lipid accumulation, insulin resistance, and contractile dysfunction, altogether termed lipotoxic cardiomyopathy (LCM). Existing treatments for LCM are limited.
Externí odkaz:
https://doaj.org/article/a0e23d30a7f945d8923dd3ba6c13acdb
Autor:
Sofija Vučković, Rafeeh Dinani, Edgar E. Nollet, Diederik W. D. Kuster, Jan Willem Buikema, Riekelt H. Houtkooper, Miranda Nabben, Jolanda van der Velden, Birgit Goversen
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a powerful tool for disease modeling, though their immature nature currently limits translation into clinical practice. Maturation strategies increasi
Externí odkaz:
https://doaj.org/article/bb40feeeeb3d4261ada3ef35f1e56c6f
Autor:
Dimitrios Kapsokalyvas, Rodrigo Rosas, Rob W. A. Janssen, Jo M. Vanoevelen, Miranda Nabben, Martin Strauch, Dorit Merhof, Marc A. M. J. van Zandvoort
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Imaging in three dimensions is necessary for thick tissues and small organisms. This is possible with tomographic optical microscopy techniques such as confocal, multiphoton and light sheet microscopy. All these techniques suffer from anisot
Externí odkaz:
https://doaj.org/article/38577ad5a5eb4a9e84cbcd84b7270387
Publikováno v:
Journal of Lipid and Atherosclerosis, Vol 9, Iss 1, Pp 66-78 (2020)
The heart faces the challenge of adjusting the rate of fatty acid uptake to match myocardial demand for energy provision at any given moment, avoiding both too low uptake rates, which could elicit an energy deficit, and too high uptake rates, which p
Externí odkaz:
https://doaj.org/article/2e276db90111441aa5852d9ba90dc0cf
Autor:
Shujin Wang, Francesco Schianchi, Dietbert Neumann, Li-Yen Wong, Aomin Sun, Frans A. van Nieuwenhoven, Maurice P. Zeegers, Agnieszka Strzelecka, Umare Col, Jan F.C. Glatz, Miranda Nabben, Joost J.F.P. Luiken
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101293- (2021)
Objective: The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H+-ATPase (v-ATPase, functioning as endosomal/lyso
Externí odkaz:
https://doaj.org/article/b07f1d46600c4e0f93aa0b55a7f9c66d
Autor:
Shujin Wang, Dietbert Neumann, B. Daan Westenbrink, Francesco Schianchi, Li-Yen Wong, Aomin Sun, Agnieszka Strzelecka, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 12909 (2022)
The heart is metabolically flexible. Under physiological conditions, it mainly uses lipids and glucose as energy substrates. In uncontrolled diabetes, the heart switches towards predominant lipid utilization, which over time is detrimental to cardiac
Externí odkaz:
https://doaj.org/article/3fefaf116d7846a3b4f7ed0ca3256a62
Autor:
Shujin Wang, Yinying Han, Miranda Nabben, Dietbert Neumann, Joost J. F. P. Luiken, Jan F. C. Glatz
Publikováno v:
Metabolites, Vol 12, Iss 7, p 579 (2022)
The heart is a metabolically flexible omnivore that can utilize a variety of substrates for energy provision. To fulfill cardiac energy requirements, the healthy adult heart mainly uses long-chain fatty acids and glucose in a balanced manner, but whe
Externí odkaz:
https://doaj.org/article/6173d029ddd14f3fb7f60a593e9606ca
Autor:
Ilvy M. E. Geraets, Will A. Coumans, Agnieszka Strzelecka, Patrick Schönleitner, Gudrun Antoons, Francesco Schianchi, Myrthe M. A. Willemars, Dimitrios Kapsokalyvas, Jan F. C. Glatz, Joost J. F. P. Luiken, Miranda Nabben
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3620 (2021)
(1) Background: The exact mechanism(s) underlying pathological changes in a heart in transition to hypertrophy and failure are not yet fully understood. However, alterations in cardiac energy metabolism seem to be an important contributor. We charact
Externí odkaz:
https://doaj.org/article/dc228c9f9206495a8e1bb0573d0e016c
Autor:
Xi Zhong, Zhongwei Zhang, Shujin Wang, Lili Cao, Lin Zhou, Aomin Sun, Zhendong Zhong, Miranda Nabben
Publikováno v:
Frontiers in Microbiology, Vol 9 (2019)
Microbe-derived butyrate plays an important role in the gut health of young mammals during the weaning stage. A greater understanding of how butyrate regulates intestinal development is necessary for overcoming post-weaning diarrheal diseases. We aim
Externí odkaz:
https://doaj.org/article/a8fe0eabd6d744239b8569ef29d1c9c8
Autor:
Francesco Schianchi, Jan F. C. Glatz, Artur Navarro Gascon, Miranda Nabben, Dietbert Neumann, Joost J. F. P. Luiken
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9438 (2020)
In the heart, inhibition of the insulin cascade following lipid overload is strongly associated with contractile dysfunction. The translocation of fatty acid transporter CD36 (SR-B2) from intracellular stores to the cell surface is a hallmark event i
Externí odkaz:
https://doaj.org/article/91e59cceefc444078e7254224db8333b