Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Miranda Mele"'
Autor:
Miranda Mele, Ricardo Vieira, Bárbara Correia, Pasqualino De Luca, Filipe V. Duarte, Paulo S. Pinheiro, Carlos B. Duarte
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Cell culture models are important tools to study epileptogenesis mechanisms. The aim of this work was to characterize the spontaneous and synchronized rhythmic activity developed by cultured hippocampal neurons after transient incubation in
Externí odkaz:
https://doaj.org/article/3e6dc83da6f64a38871222111d585ee4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
GABAA receptors (GABAAR) are the major players in fast inhibitory neurotransmission in the central nervous system (CNS). Regulation of GABAAR trafficking and the control of their surface expression play important roles in the modulation of the streng
Externí odkaz:
https://doaj.org/article/0fc23c7867a1441596d39ee226e53290
Autor:
Marta M. Vieira, Jeannette Schmidt, Joana S. Ferreira, Kevin She, Shinichiro Oku, Miranda Mele, Armanda E. Santos, Carlos B. Duarte, Ann Marie Craig, Ana Luísa Carvalho
Publikováno v:
Neurobiology of Disease, Vol 89, Iss , Pp 223-234 (2016)
Global cerebral ischemia induces selective degeneration of specific subsets of neurons throughout the brain, particularly in the hippocampus and cortex. One of the major hallmarks of cerebral ischemia is excitotoxicity, characterized by overactivatio
Externí odkaz:
https://doaj.org/article/7d7460193e4a4df9af34319a6e70f012
Autor:
Ivan Salazar, Miranda Mele, Margarida Caldeira, Rui Costa, Bárbara Correia, Simone Frisari, Carlos Duarte
Publikováno v:
Bio-Protocol, Vol 7, Iss 18 (2017)
This protocol aims at standardizing the procedure to obtain primary cultures of hippocampal and cerebrocortical neurons for in vitro experiments. Cultures should be prepared from cells isolated during embryonic development when neuronal precursor cel
Externí odkaz:
https://doaj.org/article/31eab83ae4314fff83c4b7f653421942
Publikováno v:
Neurobiology of Disease, Vol 65, Iss , Pp 220-232 (2014)
Cerebral ischemia is characterized by an early disruption of GABAergic neurotransmission contributing to an imbalance of the excitatory/inhibitory equilibrium and neuronal death, but the molecular mechanisms involved are not fully understood. Here we
Externí odkaz:
https://doaj.org/article/b665a26886ee4d448e102070dff635cd
Autor:
Andrea C. Lobo, João R. Gomes, Tatiana Catarino, Miranda Mele, Pedro Fernandez, Ana R. Inácio, Ben A. Bahr, Armanda E. Santos, Tadeusz Wieloch, Ana Luísa Carvalho, Carlos B. Duarte
Publikováno v:
Neurobiology of Disease, Vol 44, Iss 3, Pp 292-303 (2011)
Glutamate is loaded into synaptic vesicles by vesicular glutamate transporters (VGLUTs), and alterations in the transporters expression directly regulate neurotransmitter release. We investigated changes in VGLUT1 and VGLUT2 protein levels after isch
Externí odkaz:
https://doaj.org/article/4dada7c13056462ba5e4212bced3e21c
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53793 (2013)
BDNF is a pro-survival protein involved in neuronal development and synaptic plasticity. BDNF strengthens excitatory synapses and contributes to LTP, presynaptically, through enhancement of glutamate release, and postsynaptically, via phosphorylation
Externí odkaz:
https://doaj.org/article/1368c2629e274c7e8971238ab94100df
Publikováno v:
Journal of Molecular Neuroscience. 72:1500-1515
Epilepsy is a neurological disease characterized by abnormal or synchronous brain activity causing seizures, which may produce convulsions, minor physical signs, or a combination of symptoms. These disorders affect approximately 65 million people wor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856261a0b4b6b86d0589dcbb41242c67
https://doi.org/10.1007/s12031-022-02041-7
https://doi.org/10.1007/s12031-022-02041-7
Autor:
Paulo S. Pinheiro, Ana Rita Santos, Carlos B. Duarte, Ivan L. Salazar, Marta Vieira, Miranda Mele, Pasqualino De Luca
Publikováno v:
The FASEB Journal. 35
The synaptic expression of glutamate receptors of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) type is dynamically controlled by interaction with binding partners and auxiliary proteins. These proteins can be regulated by posttran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb81b0359d983ea1f27ee071512087f9
https://doi.org/10.1096/fj.201903061rr
https://doi.org/10.1096/fj.201903061rr
Autor:
Bárbara Correia, Filipe V. Duarte, Miranda Mele, Paulo S. Pinheiro, Pasqualino De Luca, Ricardo Vieira, Carlos B. Duarte
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Cell culture models are important tools to study epileptogenesis mechanisms. The aim of this work was to characterize the spontaneous and synchronized rhythmic activity developed by cultured hippocampal neurons after transient incubation in zero Mg2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7732f04b80c4730b7f3db890b27e80e
https://doi.org/10.1038/s41598-021-90486-y
https://doi.org/10.1038/s41598-021-90486-y