Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Miranda M.C. van der Lee"'
Autor:
Patrick G. Groothuis, Daniëlle C.H. Jacobs, Inge A.T. Hermens, Désirée Damming, Kim Berentsen, Ellen Mattaar-Hepp, Marloes E.M. Stokman, Tinie van Boekel, Myrthe Rouwette, Monique A.J. van der Vleuten, Aloys Sesink, Fred A. Dijcks, Ruud G.E. Coumans, Jan Schouten, Dirk H. Glaudemans, Daniëlle van Wijk, Marion Blomenröhr, Wendela A. Kappers, Ruud Ubink, Miranda M.C. van der Lee, Wim H.A. Dokter
Publikováno v:
Molecular Cancer Therapeutics. :OF1-OF13
MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely overexpressed in various solid cancer types, is an attractive target for the development of antibody-based therapeutics. BYON3521 is a novel site-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dda064791d96fa860d6ffacab7cbe223
https://doi.org/10.1158/1535-7163.mct-22-0596
https://doi.org/10.1158/1535-7163.mct-22-0596
Data from Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody–Drug Conjugate
Autor:
Wim H.A. Dokter, Miranda M.C. van der Lee, Ruud Ubink, Wendela A. Kappers, Marion Blomenröhr, Daniëlle van Wijk, Dirk H. Glaudemans, Jan Schouten, Ruud G.E. Coumans, Fred A. Dijcks, Aloys Sesink, Monique A.J. van der Vleuten, Myrthe Rouwette, Tinie van Boekel, Marloes E.M. Stokman, Ellen Mattaar-Hepp, Kim Berentsen, Désirée Damming, Inge A.T. Hermens, Daniëlle C.H. Jacobs, Patrick G. Groothuis
MET, the cell-surface receptor for the hepatocyte growth factor/scatter factor, which is widely overexpressed in various solid cancer types, is an attractive target for the development of antibody-based therapeutics. BYON3521 is a novel site-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cccdcc8e13ae8eaff0b9bd9148870aa
https://doi.org/10.1158/1535-7163.c.6653598.v1
https://doi.org/10.1158/1535-7163.c.6653598.v1
Autor:
Wim H.A. Dokter, Miranda M.C. van der Lee, Ruud Ubink, Wendela A. Kappers, Marion Blomenröhr, Daniëlle van Wijk, Dirk H. Glaudemans, Jan Schouten, Ruud G.E. Coumans, Fred A. Dijcks, Aloys Sesink, Monique A.J. van der Vleuten, Myrthe Rouwette, Tinie van Boekel, Marloes E.M. Stokman, Ellen Mattaar-Hepp, Kim Berentsen, Désirée Damming, Inge A.T. Hermens, Daniëlle C.H. Jacobs, Patrick G. Groothuis
Supplementary tables and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc6b5544991286afe57ff5b0457379b
https://doi.org/10.1158/1535-7163.22932204.v1
https://doi.org/10.1158/1535-7163.22932204.v1
Autor:
George J. Kahaly, Lisa Steiner, Miranda M.C. van der Lee, Tanja A.E. van Achterberg, Roel J. Arends, Willem F.J. Karstens, Tobias Weirauch, Jil Henseling, Lara Frommer, Jan Wolf, Augustine George
Publikováno v:
Thyroid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb047deb305ba93383d5adb2c0d5f1e0
https://doi.org/10.1089/thy.2022.0694
https://doi.org/10.1089/thy.2022.0694
Autor:
Alessandro D. Santin, Wim H.A. Dokter, C. Marco Timmers, Miranda M.C. van der Lee, Patrick H. Beusker, Peter Goedings, Peter E. Schwartz, Babak Litkouhi, Masoud Azodi, Dan-Arin Silasi, Elena Ratner, Salvatore Lopez, Serena Wong, Pei Hui, Natalia Buza, Emiliano Cocco, Christopher De Haydu, Federica Predolini, Francesca Ferrari, Elena Bonazzoli, Carlton L. Schwab, Stefania Bellone, Gulden Menderes, Jonathan Black
Exposure of all nine cell lines to scalar concentrations of ADC for a total of 6 days. IC50 dose response curves of SYD985, T-DM1 and ADC isotype control in all 9 primary USC cell lines with differential HER2 expression tested in vitro (i.e., three w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab78a65c7648dc7729220df637ca7280
https://doi.org/10.1158/1535-7163.22507497.v1
https://doi.org/10.1158/1535-7163.22507497.v1
Autor:
Alessandro D. Santin, Wim H.A. Dokter, C. Marco Timmers, Miranda M.C. van der Lee, Patrick H. Beusker, Peter Goedings, Peter E. Schwartz, Babak Litkouhi, Masoud Azodi, Dan-Arin Silasi, Elena Ratner, Salvatore Lopez, Serena Wong, Pei Hui, Natalia Buza, Emiliano Cocco, Christopher De Haydu, Federica Predolini, Francesca Ferrari, Elena Bonazzoli, Carlton L. Schwab, Stefania Bellone, Gulden Menderes, Jonathan Black
Uterine serous carcinoma (USC) is an aggressive form of endometrial cancer. Up to 35% of USC may overexpress the HER2/neu oncogene at strong (i.e., 3+) levels by IHC while an additional 40% to 50% express HER2/neu at moderate (2+) or low (1+) levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96803aeb0319979ba122bff602aec038
https://doi.org/10.1158/1535-7163.c.6538710.v1
https://doi.org/10.1158/1535-7163.c.6538710.v1
Autor:
Alessandro D. Santin, Wim H.A. Dokter, C. Marco Timmers, Miranda M.C. van der Lee, Patrick H. Beusker, Peter Goedings, Peter E. Schwartz, Babak Litkouhi, Masoud Azodi, Dan-Arin Silasi, Elena Ratner, Salvatore Lopez, Serena Wong, Pei Hui, Natalia Buza, Emiliano Cocco, Christopher De Haydu, Federica Predolini, Francesca Ferrari, Elena Bonazzoli, Carlton L. Schwab, Stefania Bellone, Gulden Menderes, Jonathan Black
Cathepsin B expression. Expression of CTSB vs GAPDH in the primary USC cell lines used for in in vitro validation experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcb104cd92d2f0894168c7c28a76f30
https://doi.org/10.1158/1535-7163.22507494
https://doi.org/10.1158/1535-7163.22507494
Autor:
Wim H.A. Dokter, Marco Timmers, Jacques M. Lemmens, Gijs F.M. Verheijden, Peter Goedings, Patrick H. Beusker, Diels van den Dobbelsteen, David F. Egging, Myrthe Rouwette, Daniëlle C.H. Jacobs, Désirée Damming, Eline M. Loosveld, Tanja A. van Achterberg, Monique A.J. van der Vleuten, Ruud Ubink, Patrick G. Groothuis, Miranda M.C. van der Lee
Table S1. Summary of status of tumors used in cell line and patient-derived xenograft models. Table S2. SYD985 and T-DM1 IC50, 95% confidence interval and % efficacy values from the in vitro cytotoxicity assays as depicted in Figure 1B. Table S3. Pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3603b07bdb54b39a88efa101b6977359
https://doi.org/10.1158/1535-7163.22501852
https://doi.org/10.1158/1535-7163.22501852
Autor:
Wim H.A. Dokter, Patrick G. Groothuis, Monique A.J. van der Vleuten, Olivier Raguin, Francis Bichat, Miranda M.C. van der Lee, Kim Berentsen, Tanja A. van Achterberg, Eline M. Loosveld, David F. Egging, Ingrid Janssen, Ebo S. Bos, Myrthe Rouwette, Eef H.C. Dirksen, Ruud Ubink
Carboxylesterase 1c (CES1c) is responsible for linker-drug instability and poor pharmacokinetics (PK) of several antibody–drug conjugates (ADC) in mice, but not in monkeys or humans. Preclinical development of these ADCs could be improved if the PK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a47be8803401330d64a7a19efd9882f0
https://doi.org/10.1158/1535-7163.c.6537982.v1
https://doi.org/10.1158/1535-7163.c.6537982.v1
Autor:
Wim H.A. Dokter, Patrick G. Groothuis, Monique A.J. van der Vleuten, Olivier Raguin, Francis Bichat, Miranda M.C. van der Lee, Kim Berentsen, Tanja A. van Achterberg, Eline M. Loosveld, David F. Egging, Ingrid Janssen, Ebo S. Bos, Myrthe Rouwette, Eef H.C. Dirksen, Ruud Ubink
Figure S1: In vitro kinetics of SYD985. Total antibody concentration during 96-hour incubation of 100 mg/mL SYD985 at 37°C in human, monkey, rat and mouse plasma (mean +/- SEM). Figure S2: Ion trap MS/MS fragmentation spectrum (HCD @30 eV) of three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58738cbeb5ef165fe450c71d01c6022a
https://doi.org/10.1158/1535-7163.22505194.v1
https://doi.org/10.1158/1535-7163.22505194.v1