Výsledky vyhledávání - "Miranda M. Y. Sung"

Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female mice

Autor: Ty T. Kim, Jason R.B. Dyck, Jeevan Nagendran, Beshay N M Zordoky, Martin E. Young, Miranda M. Y. Sung, Petra C. Kienesberger, Thomas Pulinilkunnil

Publikováno v: Heart. 99:1041-1047

Anthracyclines such as doxorubicin are an effective class of antineoplastic agents. Despite its efficacy in the treatment of a variety of cancers, the clinical use of doxorubicin is limited by cardiac side effects. While it has been suggested that do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5866e3a20aaed135b36fdf55a0cced
https://doi.org/10.1136/heartjnl-2013-303843

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Improved cardiac metabolism and activation of the RISK pathway contributes to improved post-ischemic recovery in calorie restricted mice

Autor: Grant Masson, Jamie Boisvenue, Carrie-Lynn M. Soltys, Jason R.B. Dyck, Miranda M. Y. Sung

Publikováno v: Journal of Molecular Medicine. 89:291-302

Recent evidence has suggested that activation of AMP-activated protein kinase (AMPK) induced by short-term caloric restriction (CR) protects against myocardial ischemia-reperfusion (I/R) injury. Because AMPK plays a central role in regulating energy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adead2c322058fefdd7179a94489a992
https://doi.org/10.1007/s00109-010-0703-5

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Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance

Autor: Deborah M. Muoio, Vernon W. Dolinsky, Jason R.B. Dyck, Miranda M. Y. Sung, Timothy R. Koves, Debby P.Y. Koonen, Peter E. Light, Dennis E. Vance, Maria Febbraio, Olga Ilkayeva, René L. Jacobs, Cindy K. Kao

Publikováno v: Diabetes, 59(6), 1366-1375. AMER DIABETES ASSOC
Diabetes

OBJECTIVE Although advanced age is a risk factor for type 2 diabetes, a clear understanding of the changes that occur during middle age that contribute to the development of skeletal muscle insulin resistance is currently lacking. Therefore, we sough

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220d0a51b5fe6f18b19a6a69b6a33564
https://doi.org/10.2337/db09-1142

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Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction

Autor: Jason R.B. Dyck, Erin E. Kershaw, Miranda M. Y. Sung, Peter E. Light, Martin E. Young, Guenter Haemmerle, Rudolf Zechner, Petra C. Kienesberger, Jeevan Nagendran, Gavin Y. Oudit, Thomas Pulinilkunnil

Publikováno v: Molecular and cellular biology. 32(4)

Alterations in myocardial triacylglycerol content have been associated with poor left ventricular function, suggesting that enzymes involved in myocardial triacylglycerol metabolism play an important role in regulating contractile function. Myocardia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71acaff065da5b25624d75c7e228f373
https://pubmed.ncbi.nlm.nih.gov/22158969

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Autor: Jason R.B. Dyck, Miranda M. Y. Sung

Publikováno v: Heart failure reviews. 17(4-5)

Aging is a well-recognized risk factor in the development of cardiovascular disease, which is the primary cause of death and disability in the elderly population. The normal process of aging is associated with progressive deterioration in structure a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9a03bd8e8285c42bf9457fab9795d4
https://pubmed.ncbi.nlm.nih.gov/22095297

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Increased CD36 expression in middle-aged mice contributes to obesity-related cardiac hypertrophy in the absence of cardiac dysfunction

Autor: Carrie Lynn M Soltys, Maria Febbraio, Debby P.Y. Koonen, Jason R.B. Dyck, Miranda M. Y. Sung, René L. Jacobs

Publikováno v: Journal of Molecular Medicine, 89(5), 459-469. SPRINGER HEIDELBERG

As aging is a significant risk factor for the development of left ventricular hypertrophy and cardiovascular disease, we hypothesized that hearts from middle-aged mice may be more sensitive to the effects of a high fat (HF) diet than hearts from youn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46d7fcd18b59cbd1bb163e0d16c86cf
https://research.rug.nl/en/publications/06d7a9e7-89b0-488d-9ee4-356fedf89864

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Adiponectin gene therapy ameliorates high-fat, high-sucrose diet-induced metabolic perturbations in mice

Autor: Jamie Boisvenue, A D Kandasamy, Amy J. Barr, Miranda M. Y. Sung, Jason R.B. Dyck

Publikováno v: Nutrition & Diabetes

Background and Design: Adiponectin is an adipokine secreted primarily from adipose tissue that can influence circulating plasma glucose and lipid levels through multiple mechanisms involving a variety of organs. In humans, reduced plasma adiponectin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b61517865568200cd592d175944a81
http://europepmc.org/articles/PMC3461354

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