Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Miranda M. Sung"'
Autor:
Beshay N Zordoky, Miranda M Sung, Justin Ezekowitz, Rupasri Mandal, Beomsoo Han, Trent C Bjorndahl, Souhaila Bouatra, Todd Anderson, Gavin Y Oudit, David S Wishart, Jason R B Dyck, Alberta HEART
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0124844 (2015)
Heart failure (HF) with preserved ejection fraction (HFpEF) is increasingly recognized as an important clinical entity. Preclinical studies have shown differences in the pathophysiology between HFpEF and HF with reduced ejection fraction (HFrEF). The
Externí odkaz:
https://doaj.org/article/5691576af65d4fb18a7bd3345080df69
Autor:
Miranda M. Sung, Karen Madsen, Jonathan D. Schertzer, Suresh C. Bairwa, Nirmal Parajuli, Carrie-Lynn M. Soltys, Ty T. Kim, Jason R.B. Dyck, Jody Levasseur, David S. Wishart
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 315:E511-E519
Oral administration of resveratrol attenuates several symptoms associated with the metabolic syndrome, such as impaired glucose homeostasis and hypertension. Recent work has shown that resveratrol can improve glucose homeostasis in obesity via change
Autor:
John M. Seubert, Kelvin E. Jones, Jonathan D. Schertzer, Ian M. Robertson, Carrie-Lynn M. Soltys, Victor Samokhvalov, David Fung, Nikole J. Byrne, Jody Levasseur, Neil Tyreman, Miranda M. Sung, Emmanuel Denou, Ty T. Kim, Jason R.B. Dyck
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H842-H853
We investigated whether treatment of mice with established pressure overload-induced heart failure (HF) with the naturally occurring polyphenol resveratrol could improve functional symptoms of clinical HF such as fatigue and exercise intolerance. C57
Autor:
Ian M. Robertson, Carrie-Lynn M. Soltys, Donna L. Beker, Jason R.B. Dyck, Grant Masson, Miranda M. Sung, Shereen M. Hamza, Nobutoshi Matsumura
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H561-H570
Since left ventricular hypertrophy (LVH) increases the susceptibility for the development of other cardiac conditions, pharmacotherapy that mitigates pathological cardiac remodeling may prove to be beneficial in patients with LVH. Previous work has s
Autor:
Jamie Boisvenue, Ty T. Kim, Jason R.B. Dyck, Nikole J. Byrne, Jody Levasseur, Maria Febbraio, Miranda M. Sung, Grant Masson
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 312:H552-H560
Previous studies have shown that loss of CD36 protects the heart from dysfunction induced by pressure overload in the presence of diet-induced insulin resistance and/or obesity. The beneficial effects of CD36 ablation in this context are mediated by
Autor:
Grant Masson, David S. Wishart, Shereen M. Hamza, Heekuk Park, Karen L. Madsen, Ty T. Kim, Jason R.B. Dyck, Jonathan D. Schertzer, Nikole J. Byrne, Carrie-Lynn M. Soltys, Miranda M. Sung, Emmanuel Denou
Publikováno v:
Diabetes. 66:418-425
Oral administration of resveratrol is able to improve glucose homeostasis in obese individuals. Herein we show that resveratrol ingestion produces taxonomic and predicted functional changes in the gut microbiome of obese mice. In particular, changes
Autor:
Miranda M. Sung, Jason R.B. Dyck, Ferrante S. Gragasin, Sareh Panahi, Sandra T. Davidge, Stephane L. Bourque, Alison S. Care
Publikováno v:
Hypertension. 67:1038-1044
This study was undertaken to determine whether perinatal maternal resveratrol (Resv)—a phytoalexin known to confer cardiovascular protection—could prevent the development of hypertension and improve vascular function in adult spontaneously hypert
Autor:
Jason R.B. Dyck, Miranda M. Sung
Publikováno v:
Annals of the New York Academy of Sciences. 1348:32-45
Despite existing therapies, patients with heart failure have a very poor quality of life and a high 1-year mortality rate. Given the impact of this syndrome on health outcomes, research is being directed toward identifying novel strategies to treat h
Publikováno v:
Antioxidants & Redox Signaling. 22:1606-1630
Cardiovascular complications in diabetes are particularly serious and represent the primary cause of morbidity and mortality in diabetic patients. Despite early observations of cardiac dysfunction in diabetic humans, cardiomyopathy unique to diabetes
Autor:
Vernon W. Dolinsky, Jason R.B. Dyck, Beshay N M Zordoky, Martin E. Young, Mark J. Haykowsky, Kyle J. Rogan, Miranda M. Sung, Lee W. Jones
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 305:E243-E253
Because doxorubicin (DOX)-containing chemotherapy causes left ventricular (LV) dysfunction and remodeling that can progress to heart failure, strategies to alleviate DOX cardiotoxicity are necessary to improve health outcomes of patients surviving ca