Anaphylatoxin C5a Regulates 6-Sulfo-LacNAc Dendritic Cell Function in Human through Crosstalk with Toll-Like Receptor-Induced CREB Signaling

Autor: Anouk Zaal, Miranda Dieker, Manon Oudenampsen, Annelies W. Turksma, Suzanne N. Lissenberg-Thunnissen, Diana Wouters, S. Marieke van Ham, Anja ten Brinke

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

Activation of antigen-presenting dendritic cells (DCs) and the complement system are essential early events in the immune defense against invading pathogens. Recently, we and others demonstrated immunological crosstalk between signaling from receptor

Externí odkaz: https://doaj.org/article/e2297845a94b4bcab2ed9499856b2c75

TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kβ, SGK1, and FOXO transcription factors

Autor: Miranda Dieker, S. Marieke van Ham, Benjamin Nota, Anouk Zaal, Anja ten Brinke, Kat S. Moore

Publikováno v: Journal of leukocyte biology, 102(4), 1035-1054. FASEB
Journal of Leukocyte Biology, 102(4), 1035-1054. FASEB
Zaal, A, Nota, B, Moore, K S, Dieker, M, van Ham, S M & Ten Brinke, A 2017, ' TLR4 and C5aR crosstalk in dendritic cells induces a core regulatory network of RSK2, PI3Kβ, SGK1, and FOXO transcription factors ', Journal of Leukocyte Biology, vol. 102, no. 4, pp. 1035-1054 . https://doi.org/10.1189/jlb.2MA0217-058R

Crosstalk between complement component 5a receptors (C5aRs) and TLRs in dendritic cells (DCs) occurs upon pathogen invasion; however, studies on C5aR and TLR crosstalk mainly focused on the modulating effect of C5a on TLR-induced cytokine production.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792700fe9daaa98dbc3fdc88e7f7cdc6
https://pubmed.ncbi.nlm.nih.gov/28733463

The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization

Autor: Miranda Dieker, Jaap Jan Zwaginga, S. Marieke van Ham, Miriam L. Karsten, Anja ten Brinke

Publikováno v: Vaccine, 25(41), 7145-7152. Elsevier BV

Ex vivo generated monocyte-derived dendritic cells (DCs) are used as a cellular vaccine against cancer in clinical trials. In order to be able to induce an efficient tumour-specific CTL response during immunotherapy, DCs have to be able to migrate to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadc953e59797dc8770d524b6c3eafc6
https://pure.amc.nl/en/publications/the-clinical-grade-maturation-cocktail-monophosphoryl-lipid-a-plus-ifngamma-generates-monocytederived-dendritic-cells-with-the-capacity-to-migrate-and-induce-th1-polarization(e587efee-d36f-4107-8be9-5285adb5033c).html

The major grass pollen group 5 allergen from Dactylis glomerata and its C-terminal split product both behave as dimers: Implications for allergen standardization

Autor: Erica van Oort, Miranda Dieker, Ronald van Ree, Rob C. Aalberse, Pleuni G. de Heer, Gabriel Peltre

Publikováno v: International archives of allergy and immunology, 136(2), 113-122. S. Karger AG

Background: On SDS-PAGE grass pollen group-5 allergens migrate as a doublet with an apparent molecular mass (Mr) of 25 kDa. Immunoblot analysis revealed additional group 5 reactivity at double and half this Mr. The aim of this study was to investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c1a0040e8b22219fca0cf892b5186b
https://pure.amc.nl/en/publications/the-major-grass-pollen-group-5-allergen-from-dactylis-glomerata-and-its-cterminal-split-product-both-behave-as-dimers-implications-for-allergen-standardization(7c64e6a1-0002-425d-8816-6be5f7171d4c).html