The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo

Autor: Michael H. J. Rhodin, Archie C. Reyes, Anand Balakrishnan, Nalini Bisht, Nicole M. Kelly, Joyce Sweeney Gibbons, Jonathan Lloyd, Michael Vaine, Tessa Cressey, Miranda Crepeau, Ruichao Shen, Nathan Manalo, Jonathan Castillo, Rachel E. Levene, Daniel Leonard, Tianzhu Zang, Lijuan Jiang, Kellye Daniels, Robert M. Cox, Carolin M. Lieber, Josef D. Wolf, Richard K. Plemper, Sarah R. Leist, Trevor Scobey, Ralph S. Baric, Guoqiang Wang, Bryan Goodwin, Yat Sun Or

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract The COVID-19 pandemic has led to the deaths of millions of people and severe global economic impacts. Small molecule therapeutics have played an important role in the fight against SARS-CoV-2, the virus responsible for COVID-19, but their ef

Externí odkaz: https://doaj.org/article/b18ce07e716a43029667919f23fb41e5

Fish kills and insecticides: historical water quality patterns in 10 agricultural watersheds in Prince Edward Island, Canada (2002–2022)

Autor: Miranda Crawford, Alexa C. Alexander

Publikováno v: Frontiers in Sustainable Food Systems, Vol 8 (2024)

Global pesticide use has resulted in widespread environmental degradation, persistent contamination of surface and ground waters, bioaccumulation of these contaminants in food webs, and unintended impacts on non-target species (e.g., fish kills). Mix

Externí odkaz: https://doaj.org/article/4fe76f19e14f4d08a7f94322d4049a23

Cerebral venous sinus thrombosis with an acute subdural hematoma treated with endovascular intervention: A case report

Autor: Miranda Crouch, Nathan Quig, Edward Yap, Winnie Lau

Publikováno v: Frontiers in Neurology, Vol 13 (2022)

We report two cases of endovascular intervention for management of cerebral venous sinus thrombosis complicated by an acute intracranial hemorrhage during treatment with therapeutic anticoagulation. The first patient developed an acute subdural hemat

Externí odkaz: https://doaj.org/article/62387fb69b3e4e4ba8ecb2d205f835ff

Mechanical strength and coordination defects in compressed silica glass: Molecular dynamics simulations

Autor: Liang, YF, Miranda, CR, Scandolo, S

Publikováno v: 75 (2007).
info:cnr-pdr/source/autori:Liang, YF; Miranda, CR; Scandolo, S/titolo:Mechanical strength and coordination defects in compressed silica glass: Molecular dynamics simulations/doi:/rivista:/anno:2007/pagina_da:/pagina_a:/intervallo_pagine:/volume:75

Contrary to ordinary solids, which are normally known to harden by compression, the compressibility of SiO2 (silica) glass has a maximum at about 2-4 GPa and its mechanical strength shows a minimum around 10 GPa. At this pressure, the compression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::2111972e4db98004889ed32a452dbae1
https://publications.cnr.it/doc/2227

A computational study of elastic properties of disordered systems with voids

Autor: Miranda, CR, Tretiakov, KV, Scandolo, S

Publikováno v: Journal of non-crystalline solids 352 (2006): 4283–4286.
info:cnr-pdr/source/autori:Miranda, CR; Tretiakov, KV; Scandolo, S/titolo:A computational study of elastic properties of disordered systems with voids/doi:/rivista:Journal of non-crystalline solids/anno:2006/pagina_da:4283/pagina_a:4286/intervallo_pagine:4283–4286/volume:352

We present a computational study of elastic properties of disordered systems with voids. The influence of hydrogen and voids on the elastic properties has been investigated by means of atomistic simulations using empirical potentials for hydrogenated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::9a78833ab1ef98ed5f6361a4cfc7e8cf
https://publications.cnr.it/doc/217