Výsledky vyhledávání - "Miranda Batchelor"

Mutagenesis of conserved tryptophan residues within the receptor-binding domain of intimin: influence on binding activity and virulence

Autor: Stephen Reece, Christine Hale, Miranda Batchelor, Gad Frankel, Gordon Dougan, Alan D. Phillips, Cameron P. Simmons, Robert J. Fitzhenry, Stephen Matthews

Publikováno v: Scopus-Elsevier

Intimate bacterial adhesion to intestinal epithelium is a pathogenic mechanism shared by several human and animal enteric pathogens, including enteropathogenic and enterohaemorrhagic Escherichia coli and Citrobacter rodentium. The proteins directly i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921286486bd59415d7f4176566b1344f
https://ora.ox.ac.uk/objects/uuid:ec067a92-f365-4794-b307-40f0a216282e

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Identification of CesT, a chaperone for the type III secretion of Tir in enteropathogenic Escherichia coli

Autor: Miranda Batchelor, Stuart Knutton, Steven W. Hutcheson, Jay L. Mellies, Simon J. Elliott, James B. Kaper, Maria S. Dubois, Gad Frankel, Leslie A. Wainwright

Publikováno v: Molecular Microbiology. 33:1176-1189

The locus of enterocyte effacement of enteropathogenic Escherichia coli encodes a type III secretion system, an outer membrane protein adhesin (intimin, the product of eae ) and Tir, a translocated protein that becomes a host cell receptor for intimi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0649021014d611a60ae7c4d8a7cdb0f
https://doi.org/10.1046/j.1365-2958.1999.01559.x

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EspF of Enteropathogenic Escherichia coli Binds Sorting Nexin 9

Autor: Richard Lundmark, Céline Cougoule, Robert K. Shaw, Oliver Marchès, Amit Patel, Takeshi Nagai, Ian F. Connerton, Sven R. Carlsson, Gad Frankel, Miranda Batchelor, Emmanuelle Caron, Nicola J. Cummings, Chihiro Sasakawa, Stuart Knutton

Publikováno v: Journal of Bacteriology
Journal of Bacteriology, American Society for Microbiology, 2006, 188 (8), pp.3110-3115. ⟨10.1128/JB.188.8.3110-3115.2006⟩

EspF of enteropathogenic Escherichia coli targets mitochondria and subverts a number of cellular functions. EspF consists of six putative Src homology 3 (SH3) domain binding motifs. In this study we identified sorting nexin 9 (SNX9) as a host cell Es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b1056221a34c0c2dead843882e1f97
https://europepmc.org/articles/PMC1447016/

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Host protein interactions with enteropathogenic Escherichia coli (EPEC): 14-3-3tau binds Tir and has a role in EPEC-induced actin polymerization

Autor: Ian F. Connerton, Thierry Dubois, Nicola J. Cummings, Miranda Batchelor, Gad Frankel, Amit Patel, Phillip J. Hill, Kenneth H. Mellits

Publikováno v: Cellular microbiology. 8(1)

Summary Enteropathogenic Escherichia coli (EPEC) cause infantile diarrhoea and are characterized by their ability to produce attaching and effacing lesions on the surface of intestinal epithelial cells. EPEC employ a filamentous type III secretion sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6118958c59fea141141cf2a09fc67e14
https://pubmed.ncbi.nlm.nih.gov/16367866

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Persistence of Escherichia coli O157 isolates on bovine farms in England and Wales

Autor: Claire Cassar, Miranda Batchelor, I. McLaren, Ernesto Liebana, G. A. Paiba, R. P. Smith, Felicity A. Clifton-Hadley

Publikováno v: Journal of clinical microbiology. 43(2)

We performed pulsed-field gel electrophoresis on Escherichia coli O157 isolates ( n = 318) from 199 healthy animals in a longitudinal study carried out on nine farms. Investigation of the restriction types proved that at the farm level, the same clon

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https://pubmed.ncbi.nlm.nih.gov/15695700

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Antibody response of patients infected with verocytotoxin-producing Escherichia coli to protein antigens encoded on the LEE locus

Autor: Claire Jenkins, Robin M. Delahay, G. Dougan, Gad Frankel, Henry R. Smith, Elizabeth L. Hartland, Miranda Batchelor, Henrik Chart

Publikováno v: Europe PubMed Central
Monash University

Sera from patients infected with verocytotoxin-producing Escherichia coli (VTEC) O157, from patients with antibodies to E. coli O157 lipopolysaccharide (LPS) and from healthy controls were examined for antibodies to proteins involved in expressing th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05acd25972cc7d812b2ff2c1a7ad3012
https://pubmed.ncbi.nlm.nih.gov/10628831

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Development of a universal intimin antiserum and PCR primers

Autor: Veronika Huter, Gad Frankel, Alfredo Caprioli, Miranda Batchelor, Gordon Dougan, Stuart Knutton, Mazlina Zanial

Publikováno v: Journal of clinical microbiology. 37(12)

Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) constitute a significant risk to human health worldwide. A hallmark of both pathogens is their ability to produce characteristic attaching-and-effacing (A/E) lesions in int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dbe3b1911828b99b7eba8f29d6198c8
https://pubmed.ncbi.nlm.nih.gov/10565891

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Binding of intimin from enteropathogenic Escherichia coli to Tir and to host cells

Autor: Gordon Dougan, Gad Frankel, Robin M. Delahay, Elizabeth L. Hartland, Ian F. Connerton, Miranda Batchelor, Stephen Matthews, Christine Hale, Stuart Knutton

Publikováno v: Molecular microbiology. 32(1)

Enteropathogenic Escherichia coli (EPEC) induce characteristic attaching and effacing (A/E) lesions on epithelial cells. This event is mediated, in part, by binding of the bacterial outer membrane protein, intimin, to a second EPEC protein, Tir (tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b06151693cd048beb0102c658f2854e
https://pubmed.ncbi.nlm.nih.gov/10216868

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Generation of Escherichia coli intimin derivatives with differing biological activities using site-directed mutagenesis of the intimin C-terminus domain

Autor: Susan Hicks, Gordon Dougan, Gad Frankel, Alan D. Philips, Miranda Batchelor, Michaela Novakova

Publikováno v: Molecular microbiology. 29(2)

Intimins, encoded by eae genes, are outer membrane proteins involved in attaching–effacing (A/E) lesion formation and host cell invasion by pathogenic bacteria, including enteropathogenic Escherichia coli (EPEC) and Citrobacter rodentium. A series

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ec2339ff72f59ae536bc5fc9a071a64
https://pubmed.ncbi.nlm.nih.gov/9720872

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Involvement of the intermediate filament protein cytokeratin‐18 in actin pedestal formation during EPEC infection

Autor: Nicola J. Cummings, Miranda Batchelor, Stuart Knutton, Amit Patel, Julie Guignot, Ian F. Connerton, David W. Holden, Jennifer Cleary, Gad Frankel

Publikováno v: EMBO reports. 5:219-219

While remaining extracellular, enteropathogenic Escherichia coli (EPEC) establish direct links with the cytoskeleton of the target epithelial cell leading to the formation of actin-rich pedestals underneath attached bacteria. The translocated adaptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356d755e25a0024dceb2e926f95c0979
https://doi.org/10.1038/sj.embor.7400087

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