Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Miranda Aalderink"'
Autor:
Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Smyth et al. use tissue microarrays from Alzheimer’s disease (AD) patient brains to show that PDGF-BB:PDGFRβ signalling components are reduced in AD. They then use primary human brain pericytes to elucidate a pathway by which PDGF-BB:PDGFRβ signa
Externí odkaz:
https://doaj.org/article/ac4315ac00c245ed917bf0edddaef79a
Autor:
Amy M. Smith, Thomas In-Hyeup Park, Miranda Aalderink, Robyn L. Oldfield, Peter S. Bergin, Edward W. Mee, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The study of microglia isolated from adult human brain tissue provides unique insight into the physiology of these brain immune cells and their role in adult human brain disorders. Reports of microglia in post-mortem adult human brain tissue show reg
Externí odkaz:
https://doaj.org/article/c5eff623830540a29eefa250fa8e6004
Autor:
Deidre Jansson, Victor Birger Dieriks, Justin Rustenhoven, Leon C. D. Smyth, Emma Scotter, Miranda Aalderink, Sheryl Feng, Rebecca Johnson, Patrick Schweder, Edward Mee, Peter Heppner, Clinton Turner, Maurice Curtis, Richard Faull, Mike Dragunow
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Jansson et al. design a high content screening system to target inflammation in human brain cells of the blood–brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers. They identify cardiac glycosides as powerful regulato
Externí odkaz:
https://doaj.org/article/16813cdb8f5946e8a7e3b8526d12998c
Autor:
Justin Rustenhoven, Amy M. Smith, Leon C. Smyth, Deidre Jansson, Emma L. Scotter, Molly E. V. Swanson, Miranda Aalderink, Natacha Coppieters, Pritika Narayan, Renee Handley, Chris Overall, Thomas I. H. Park, Patrick Schweder, Peter Heppner, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-16 (2018)
Abstract Background Microglia play critical roles in the brain during homeostasis and pathological conditions. Understanding the molecular events underpinning microglial functions and activation states will further enable us to target these cells for
Externí odkaz:
https://doaj.org/article/61d01fe126004e1d9256ea1766c25fa5
Autor:
E Scott Graham, Kerhan K Woo, Miranda Aalderink, Sandie Fry, Jeffrey M Greenwood, Michelle Glass, Mike Dragunow
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72011 (2013)
HEK293 cells have been used extensively to generate stable cell lines to study G protein-coupled receptors, such as muscarinic acetylcholine receptors (mAChRs). The activation of M1 mAChRs in various cell types in vitro has been shown to be protectiv
Externí odkaz:
https://doaj.org/article/b5d068d9909949768e81ab33fea29383
Autor:
Thomas I.-H. Park, Leon C. D. Smyth, Miranda Aalderink, Zoe R. Woolf, Justin Rustenhoven, Kevin Lee, Deidre Jansson, Amy Smith, Sheryl Feng, Jason Correia, Peter Heppner, Patrick Schweder, Edward Mee, Mike Dragunow
Publikováno v:
Nature Protocols. 17:190-221
When modeling disease in the laboratory, it is important to use clinically relevant models. Patient-derived human brain cells grown in vitro to study and test potential treatments provide such a model. Here, we present simple, highly reproducible coo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01203b468e4e91b5c4fff19aab190b44
https://doi.org/10.1038/s41596-021-00637-8
https://doi.org/10.1038/s41596-021-00637-8
Autor:
Leon C. D. Smyth, Blake Highet, Deidre Jansson, Jane Wu, Justin Rustenhoven, Miranda Aalderink, Adelie Tan, Susan Li, Rebecca Johnson, Natacha Coppieters, Renee Handley, Pritika Narayan, Malvindar K. Singh-Bains, Patrick Schweder, Clinton Turner, Edward W. Mee, Peter Heppner, Jason Correia, Thomas I.-H. Park, Maurice A. Curtis, Richard L. M. Faull, Mike Dragunow
Publikováno v:
Communications biology. 5(1)
Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment and pericyte loss in Alz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78707940c98a299d8b9bf86c4461856f
https://pubmed.ncbi.nlm.nih.gov/35301433
https://pubmed.ncbi.nlm.nih.gov/35301433
Autor:
Mike Dragunow, Emma L. Scotter, Clinton Turner, Peter Heppner, Victor Birger Dieriks, Maurice A. Curtis, Patrick Schweder, Miranda Aalderink, Deidre Jansson, Leon Smyth, Justin Rustenhoven, Rebecca Johnson, Richard L.M. Faull, Sheryl Feng, Edward W. Mee
Neuroinflammation is a key component of virtually all neurodegenerative diseases; preceding neuronal loss and associating directly with cognitive impairment. Neuroinflammatory signals can originate and be amplified at barrier tissues such as brain va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bd1654a940a9361aa95a1dc3b3c536
https://doi.org/10.1101/2020.04.15.043588
https://doi.org/10.1101/2020.04.15.043588
Synthesis of peptide homo‐ and heterodimers as potential mimics of platelet‐derived growth factor BB
Autor:
Louise A. Stubbing, Mike Dragunow, Miranda Aalderink, Harveen Kaur, Margaret A. Brimble, Sheryl Feng
Publikováno v:
Peptide Science. 112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c407a7351efe738c3db073d63707cfff
https://doi.org/10.1002/pep2.24150
https://doi.org/10.1002/pep2.24150
Autor:
Peter Heppner, Mike Dragunow, Thomas I. H. Park, Patrick Schweder, Miranda Aalderink, Natacha Coppieters, Richard L.M. Faull, Molly E. V. Swanson, Amy M. Smith, Pritika Narayan, Maurice A. Curtis, Deidre Jansson, Emma L. Scotter, Christopher C. Overall, Justin Rustenhoven, Leon Smyth, Renee R. Handley
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-16 (2018)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Microglia play critical roles in the brain during homeostasis and pathological conditions. Understanding the molecular events underpinning microglial functions and activation states will further enable us to target these cells for the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e489d865d7fb8a41ad0c877cee2b68
http://link.springer.com/article/10.1186/s13024-018-0277-1
http://link.springer.com/article/10.1186/s13024-018-0277-1