Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Miranda A. Salvo"'
Autor:
Alia O. Alia, Sohee Jeon, Jelena Popovic, Miranda A. Salvo, Katherine R. Sadleir, Robert Vassar, Leah K. Cuddy
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Current scientific research is driven by the ability to manipulate gene expression by utilizing the Cre/loxP system in transgenic mouse models. However, artifacts in Cre-driver mouse lines that introduce undesired effects and confound result
Externí odkaz:
https://doaj.org/article/167aa54b5aac49f5b0590a07a00301e3
Autor:
Leah K. Cuddy, Alia O. Alia, Miranda A. Salvo, Sidhanth Chandra, Tom N. Grammatopoulos, Craig J. Justman, Peter T. Lansbury, Joseph R. Mazzulli, Robert Vassar
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-23 (2022)
Abstract Background Amyloid plaque deposition and axonal degeneration are early events in AD pathogenesis. Aβ disrupts microtubules in presynaptic dystrophic neurites, resulting in the accumulation of impaired endolysosomal and autophagic organelles
Externí odkaz:
https://doaj.org/article/e44cfb2c142247068fdf496e4be970c6