Control of NFAT Isoform Activation and NFAT-Dependent Gene Expression through Two Coincident and Spatially Segregated Intracellular Ca2+ Signals

Autor: Kar, P, Mirams, GR, Christian, HC, Parekh, A

Publikováno v: Molecular Cell. 64(4):746-759

Excitation-transcription coupling, linking stimulation at the cell surface to changes in nuclear gene expression, is conserved throughout eukaryotes. How closely related coexpressed transcription factors are differentially activated remains unclear.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fa13fb435bf088d5c9a04394dd5cc776

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing

Autor: Quinn, TA, Granite, S, Allessie, MA, Antzelevitch, C, Bollensdorff, C, Bub, G, Burton, RAB, Cerbai, E, Chen, PS, Delmar, M, Difrancesco, D, Earm, YE, Efimov, IR, Egger, M, Entcheva, E, Fink, M, Fischmeister, R, Franz, MR, Garny, A, Giles, WR, Hannes, T, Harding, SE, Hunter, PJ, Iribe, G, Jalife, J, Johnson, CR, Kass, RS, Kodama, I, Koren, G, Lord, P, Markhasin, VS, Matsuoka, S, McCulloch, AD, Mirams, GR, Morley, GE, Nattel, S, Noble, D, Olesen, SP, Panfilov, AV, Trayanova, NA, Ravens, U, Richard, S, Rosenbaum, DS, Rudy, Y, Sachs, F, Sachse, FB, Saint, DA, Schotten, U, Solovyova, O, Taggart, P, Tung, L, Varró, A, Volders, PG, Wang, K, Weiss, JN, Wettwer, E, White, E, Wilders, R, Winslow, RL, Kohl, P

Publikováno v: Progress in biophysics and molecular biology, vol 107, iss 1

Cardiac experimental electrophysiology is in need of a well-defined Minimum Information Standard for recording, annotating, and reporting experimental data. As a step towards establishing this, we present a draft standard, called Minimum Information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::853281ce41da7e984c769215fa1a17e5
https://escholarship.org/uc/item/1dt0q2g5

Ten simple rules for training scientists to make better software.

Autor: Gallagher K; Doctoral Training Centre, University of Oxford, Oxford, United Kingdom., Creswell R; Department of Computer Science, University of Oxford, Oxford, United Kingdom., Lambert B; Department of Statistics, University of Oxford, Oxford, United Kingdom., Robinson M; Department of Computer Science, University of Oxford, Oxford, United Kingdom., Lok Lei C; Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau, China., Mirams GR; Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom., Gavaghan DJ; Doctoral Training Centre, University of Oxford, Oxford, United Kingdom.

Publikováno v: PLoS computational biology [PLoS Comput Biol] 2024 Sep 12; Vol. 20 (9), pp. e1012410. Date of Electronic Publication: 2024 Sep 12 (Print Publication: 2024).

Neural network emulation of the human ventricular cardiomyocyte action potential for more efficient computations in pharmacological studies.

Autor: Grandits T; Department of Mathematics and Scientific Computing, University of Graz, Graz, Austria.; NAWI Graz, University of Graz, Graz, Austria., Augustin CM; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging - Division of Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria., Haase G; Department of Mathematics and Scientific Computing, University of Graz, Graz, Austria., Jost N; Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.; HUN-REN-TKI, Research Group of Pharmacology, Budapest, Hungary., Mirams GR; Centre for Mathematical Medicine & Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom., Niederer SA; Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom., Plank G; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging - Division of Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.; BioTechMed-Graz, Graz, Austria., Varró A; Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary.; HUN-REN-TKI, Research Group of Pharmacology, Budapest, Hungary., Virág L; Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary., Jung A; Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging - Division of Medical Physics and Biophysics, Medical University of Graz, Graz, Austria.

Publikováno v: ELife [Elife] 2024 Apr 10; Vol. 12. Date of Electronic Publication: 2024 Apr 10.

Compartmentalization proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation.

Autor: Ayagama T; Department of Pharmacology, University of Oxford, Oxford, UK., Charles PD; Target Discovery Institute, University of Oxford, Oxford, UK., Bose SJ; Department of Pharmacology, University of Oxford, Oxford, UK., Boland B; Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland., Priestman DA; Department of Pharmacology, University of Oxford, Oxford, UK., Aston D; Department of Anaesthesia and Critical Care, Royal Papworth Hospital NHS Foundation Trust, Papworth Road, Cambridge CB2 0AY, UK., Berridge G; Target Discovery Institute, University of Oxford, Oxford, UK., Fischer R; Target Discovery Institute, University of Oxford, Oxford, UK., Cribbs AP; Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Headington OX3 7LD, UK., Song Q; Department of Pharmacology, University of Oxford, Oxford, UK., Mirams GR; Centre for Mathematical Medicine & Biology, Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Amponsah K; Centre for Mathematical Medicine & Biology, Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK., Heather L; Department of Physiology, Anatomy and Genetics, , University of Oxford, South Park Road, Oxford OX1 3PT, UK., Galione A; Department of Pharmacology, University of Oxford, Oxford, UK., Herring N; Department of Physiology, Anatomy and Genetics, , University of Oxford, South Park Road, Oxford OX1 3PT, UK., Kramer H; Mass spectrometry Facility, The MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK., Capel RA; Department of Pharmacology, University of Oxford, Oxford, UK., Platt FM; Department of Pharmacology, University of Oxford, Oxford, UK., Schotten U; Departments of Physiology and Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands., Verheule S; Departments of Physiology and Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands., Burton RAB; Department of Pharmacology, University of Oxford, Oxford, UK.; University of Liverpool, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, Liverpool, UK.

Publikováno v: IScience [iScience] 2024 Mar 28; Vol. 27 (6), pp. 109609. Date of Electronic Publication: 2024 Mar 28 (Print Publication: 2024).