Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mira Zhang"'
Publikováno v:
Blood Adv
Dose control of warfarin is a major complication in anticoagulation therapy and overdose is reversed by the vitamin K antidote. Improving the dosage management and antidotal efficacy requires mechanistic understanding. Here we find that effects of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a4130ec35dcecf1dac1f0a9dc80203c
https://doi.org/10.1182/bloodadvances.2020001750
https://doi.org/10.1182/bloodadvances.2020001750
Publikováno v:
Chem Rev
Proteins adopt different higher-order structures (HOS) to enable their unique biological functions. Understanding the complexities of protein higher-order structures and dynamics requires integrated approaches, where mass spectrometry (MS) is now pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdcfffda3147dfa1a751eedb6f678d9
https://doi.org/10.1021/acs.chemrev.9b00815
https://doi.org/10.1021/acs.chemrev.9b00815
Autor:
Michael L. Gross, Brett R. Beno, Mengru Mira Zhang, Ekaterina G. Deyanova, Guodong Chen, Richard Y.-C. Huang, Jing Li, Jagat Adhikari
Publikováno v:
Analytical Chemistry. 91:15709-15717
We describe an integrated approach of using hydrogen–deuterium exchange mass spectrometry (HDX-MS), chemical cross-linking mass spectrometry (XL-MS), and molecular docking to characterize the bindi...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66356db7fe08c8ca2608f5102770b8a4
https://doi.org/10.1021/acs.analchem.9b03879
https://doi.org/10.1021/acs.analchem.9b03879
Publikováno v:
Anal Chem
Fast photochemical oxidation of protein (FPOP) has become an important mass spectrometry-based protein footprinting approach. Although the hydroxyl radical (·OH) generated by photolysis of hydrogen peroxide (H(2)O(2)) is most commonly used, the path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca8cf5c7e98ca119509ff09c63bac01
https://doi.org/10.1021/acs.analchem.9b02134
https://doi.org/10.1021/acs.analchem.9b02134
Publikováno v:
Anal Chem
We found that a newly developed method named LITPOMS (ligand titration, fast photochemical oxidation of proteins and mass spectrometry) can characterize section-by-section of a protein the conformational changes induced by metal-ion binding. Peptide-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1517816dd236f51a30622e26939bd4
https://doi.org/10.1021/acs.analchem.9b01062
https://doi.org/10.1021/acs.analchem.9b01062
Autor:
Himadri B. Pakrasi, Ming Cheng, Daniel A. Weisz, Mengru Mira Zhang, Robert E. Blankenship, Haijun Liu
Publikováno v:
Science Advances
Cyanobacterial light-harvesting complex features efficient energy capture, transmission, and regulation to reaction centers.
In cyanobacteria and red algae, the structural basis dictating efficient excitation energy transfer from the phycobiliso
In cyanobacteria and red algae, the structural basis dictating efficient excitation energy transfer from the phycobiliso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb0b77e7271b85d8f6b44a3cc86b6c8
https://doi.org/10.1126/sciadv.aba5743
https://doi.org/10.1126/sciadv.aba5743
Autor:
Richard Y.-C. Huang, Mengru Mira Zhang, Ekaterina G. Deyanova, Guodong Chen, Brett R. Beno, Michael L. Gross, Jing Li
Publikováno v:
Anal Chem
Programmed cell death-1 (PD-1), an antigen co-receptor on cell surfaces, is one of the conspicuous immune checkpoints. Nivolumab, a monoclonal antibody therapeutic approved by the FDA, binds to PD-1 and efficiently blocks its pathways. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c429197fe78031494ee4a08ac9b8fee5
https://europepmc.org/articles/PMC7501946/
https://europepmc.org/articles/PMC7501946/
Publikováno v:
Journal of the American Society for Mass Spectrometry. 30:213-217
We report a novel method named LITPOMS (ligand titration, fast photochemical oxidation of proteins and mass spectrometry) to characterize protein-ligand binding stoichiometry, binding sites, and site-specific binding constants. The system used to tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281796c3b3ceee58d69a4d15fd524096
https://doi.org/10.1007/s13361-018-2076-x
https://doi.org/10.1007/s13361-018-2076-x
Autor:
Robert E. Blankenship, Himadri B. Pakrasi, Ming Cheng, Mengru Mira Zhang, Michael L. Gross, Daniel A. Weisz, Haijun Liu, Hao Zhang, Gary S. Gerstenecker, Bojie Zhang
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
mBio, Vol 10, Iss 2, p e00669-19 (2019)
mBio, vol 10, iss 2
mBio, Vol 10, Iss 2, p e00669-19 (2019)
mBio, vol 10, iss 2
Cyanobacterial phycobilisomes (PBSs) are photosynthetic antenna complexes that harvest light energy and supply it to two reaction centers (RCs) where photochemistry starts. PBSs can be classified into two types, depending on the presence of allophyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759849f403fa032564f16be51bfa629b
https://journals.asm.org/doi/10.1128/mBio.00669-19
https://journals.asm.org/doi/10.1128/mBio.00669-19
Publikováno v:
Free radical biologymedicine. 131
Fast Photochemical Oxidation of Protein (FPOP), based on a pulsed KrF laser (248 nm) for free-radical generation, is a biophysical method that utilizes hydroxyl radicals to footprint proteins in solution. FPOP has been recognized for structural prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::415e5a12bda2afba5481659ff45bf33c
https://pubmed.ncbi.nlm.nih.gov/30502457
https://pubmed.ncbi.nlm.nih.gov/30502457