Residues essential for Panton-Valentine leukocidin S component binding to its cell receptor suggest both plasticity and adaptability in its interaction surface.

Autor: Benoit-Joseph Laventie, Frédéric Guérin, Lionel Mourey, Mira Y Tawk, Emmanuel Jover, Laurent Maveyraud, Gilles Prévost

Publikováno v: PLoS ONE, Vol 9, Iss 3, p e92094 (2014)

Panton-Valentine leukocidin (PVL), a bicomponent staphylococcal leukotoxin, is involved in the poor prognosis of necrotizing pneumonia. The present study aimed to elucidate the binding mechanism of PVL and in particular its cell-binding domain. The c

Externí odkaz: https://doaj.org/article/04d6238a46724c8288b5f7d313c76ba6

Interleukin 6 receptor inhibition in primary Sjögren syndrome: a multicentre double-blind randomised placebo-controlled trial

Autor: Christophe Richez, S. Rist, Christelle Sordet, Valérie Devauchelle-Pensec, Aleth Perdriger, Jacques Morel, Azeddine Dellal, Claire Larroche, Alain Saraux, Carine Salliot, Arsène Mekinian, Raphaèle Seror, Philippe Dieudé, Jean Sibilia, David Saadoun, Thierry Martin, Renaud Felten, Eric Hachulla, Charles Zarnitsky, Emanuelle Dernis, A. Contis, P. Kieffer, Patrice Cacoub, Jean-Marie Berthelot, Mira Y Tawk, Olivier Vittecoq, Lise Holterbach, Ouafaa Aberkane, Véronique Le Guern, Gilles Blaison, Nicolas Meyer, Cécile Arnold, Emmanuel Chatelus, François Maurier, Hatron Pierre Yves, Emmanuel Andrès, Pierre Duffau, Xavier Mariette, Jacques-Eric Gottenberg

Publikováno v: Annals of the Rheumatic Diseases
Annals of the Rheumatic Diseases, BMJ Publishing Group, 2021, 80 (3), pp.329-338. ⟨10.1136/annrheumdis-2020-218467⟩

ObjectivesNo immunomodulatory drug has been approved for primary Sjögren’s syndrome, a systemic autoimmune disease affecting 0.1% of the population. To demonstrate the efficacy of targeting interleukin 6 receptor in patients with Sjögren’s synd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc07f58bad38b830eb73ee1d9abb7f4
https://hal.umontpellier.fr/hal-03229642

Staphylococcal leukotoxins trigger free intracellularCa2+rise in neurones, signalling through acidic stores and activation of store‐operated channels

Autor: Gilles Prévost, Emmanuel Jover, Benoît-Joseph Laventie, Mira Y. Tawk, Bernard Poulain

Publikováno v: Cellular Microbiology

Headache, muscle aches and chest pain of mild to medium intensity are among the most common clinical symptoms in moderate Staphylococcus aureus infections, with severe infections usually associated with worsening pain symptoms. These nociceptive resp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89277a3599560faf196c937bcb7009a9
https://doi.org/10.1111/cmi.12069

List of Contributors

Autor: Klaus Aktories, Alberto Alape-Girón, Julien Barbier, Joseph T. Barbieri, Holger Barth, Ajit K. Basak, Roland Benz, Kinga Bercsenyi, Jonas Bergan, Stefan Bergmann, Sergey M. Bezrukov, Victoria A. Bjørnestad, Patrice Boquet, Laurent Boyer, Alejandra Bravo, Amy E. Bryant, Ladislav Bumba, Pablo Emiliano Cantón, Alexandre Chenal, Matteo Dal Peraro, Marcela de Souza Santos, Ulrich Dobrindt, J. Oliver Dolly, J. Daniel Dubreuil, Alain Filloux, Dara W. Frank, Marietta Flores-Díaz, John D. Fraser, Teresa Frisan, Jorge E. Galan, Blanca I. García-Gómez, Harald Genth, Daniel Gillet, Isabel Gómez, Per Einar Granum, Jörg Hacker, Callista B. Harper, Julie E. Heggelund, Mengfei Ho, Eileen M. Hotze, Jessica Huyet, Ioan Iacovache, Thomas Jank, Emmanuel Jover, Ingo Just, Anne-Marie Krachler, Ute Krengel, Daniel Ladant, Ries J. Langley, Emmanuel Lemichez, Stephen H. Leppla, Peng Li, Toril Lindbäck, Anne Berit Dyve Lingelem, Shihui Liu, Camille Locht, Diana L. Martínez de Castro, Jiri Masin, Bruce A. McClane, Adam McCluskey, Gretel Mendoza, Frederic A. Meunier, Mahtab Moayeri, Jordi Molgó, Laura Monturiol-Gross, Patrick Munro, Claire E. Naylor, Ekaterina M. Nestorovich, Josue Ocelotl, Janette Onofre, Joachim H.C. Orth, Kim Orth, Radim Osicka, Sabino Pacheco, Andrei P. Pomerantsev, Michel R. Popoff, Bernard Poulain, Gilles Prévost, Thomas Proft, Vittorio Ricci, Phillip J. Robinson, Stephanie Rolsma, Virginia I. Roxas-Duncan, Agnes Sagfors, Dor Salomon, Jorge Sánchez, Kirsten Sandvig, Christos Savva, Giampietro Schiavo, Gudula Schmidt, Nathalie Schmieg, Peter Sebo, Sadrick Shah, Archana Shrestha, Tore Skotland, Leonard A. Smith, Mario Soberón, Patrizia Sommi, A.C. Sotomayor-Perez, Dennis L. Stevens, Bradley G. Stiles, Mira Y. Tawk, Richard Titball, Sarah Tjaden, Rodney K. Tweten, Françoise Gisou van der Goot, Kristin R. Wade, Jiafu Wang, Brenda A. Wilson, Gaëlle Zimmermann-Meisse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c17236163b59dfe980e5c2e931932031
https://doi.org/10.1016/b978-0-12-800188-2.00043-4

Staphylococcal Panton-Valentine leucotoxin targets retina through the ganglion cell layer in a rabbit toxin-induced endophthalmitis model

Autor: Gilles Prévost, Mira Y. Tawk, Pauline Heitz, David Gaucher

Publikováno v: Acta Ophthalmologica. 92

Purpose Staphylococcal leucotoxins form a cluster of bi-component leucotoxins that are associated with tissue necrosis pathologies, such as necrotising pneumonia, osteomyelitis and endophtalmitis. Among them, Panton-Valentine leucotoxine (PVL) is oft

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ca0033afe51f568aecff93f9a12a44b
https://doi.org/10.1111/j.1755-3768.2014.t057.x