Výsledky vyhledávání

Akademický článek

Using the SNAP-Tag technology to easily measure and demonstrate apoptotic changes in cancer and blood cells with different dyes.

Autor: Mira Woitok, Elena Grieger, Olusiji A Akinrinmade, Susanne Bethke, Anh Tuan Pham, Christoph Stein, Rolf Fendel, Rainer Fischer, Stefan Barth, Judith Niesen

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0243286 (2020)

In vitro and ex vivo development of novel therapeutic agents requires reliable and accurate analyses of the cell conditions they were preclinical tested for, such as apoptosis. The detection of apoptotic cells by annexin V (AV) coupled to fluorophore

Externí odkaz: https://doaj.org/article/c05b4978132b4524b68c1177dd13fb04

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Generation of an artificial human B cell line test system using Transpo-mAbTM technology to evaluate the therapeutic efficacy of novel antigen-specific fusion proteins.

Autor: Diana Klose, Mira Woitok, Judith Niesen, Roger R Beerli, Ulf Grawunder, Rainer Fischer, Stefan Barth, Rolf Fendel, Thomas Nachreiner

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180305 (2017)

The antigen-specific targeting of autoreactive B cells via their unique B cell receptors (BCRs) is a novel and promising alternative to the systemic suppression of humoral immunity. We generated and characterized cytolytic fusion proteins based on an

Externí odkaz: https://doaj.org/article/3d8df7af4837489b88b6d6e8d638ee06

Zobrazit plný text záznamu

Using the SNAP-Tag technology to easily measure and demonstrate apoptotic changes in cancer and blood cells with different dyes

Autor: Rolf Fendel, Olusiji A. Akinrinmade, Elena Grieger, Mira Woitok, Stefan Barth, Susanne Bethke, Anh Tuan Pham, Judith Niesen, Christoph Stein, Rainer Fischer

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0243286 (2020)
PLOS ONE 15(12), e0243286 (2020). doi:10.1371/journal.pone.0243286
PLoS ONE

PLOS ONE 15(12), e0243286 (2020). doi:10.1371/journal.pone.0243286
Published by PLOS, San Francisco, California, US

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51345232a46621c440d1f744167d0e1a
https://doaj.org/article/c05b4978132b4524b68c1177dd13fb04

Zobrazit plný text záznamu

Plný text ve formátu HTML

A novel fully-human cytolytic fusion protein based on granzyme B shows in vitro cytotoxicity and ex vivo binding to solid tumors overexpressing the epidermal growth factor receptor

Autor: Mira Woitok, Christoph Stein, Rainer Fischer, Stefan Barth, Rolf Fendel, Judith Niesen, Grit Hehmann-Titt

Publikováno v: Cancer Letters. 374:229-240

Human cytolytic fusion proteins (hCFPs) offer a promising immunotherapeutic approach for the treatment of solid tumors, avoiding the immunogenicity and undesirable side-effects caused by immunotoxins derived from plants or bacteria. The well-characte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed22e62cf29e3e165e765ed4a225f00
https://doi.org/10.1016/j.canlet.2016.02.020

Zobrazit plný text záznamu

A specific photoimmunotheranostics agent to detect and eliminate skin cancer cells expressing EGFR

Autor: Verena von Felbert, Stefan Barth, Mira Woitok, K. Bräutigam, Ivo Meinhold-Heerlein, Ahmad Fawzi Hussain, Dirk Bauerschlag, Nicolai Maass

Publikováno v: Journal of Cancer Research and Clinical Oncology. 142:1003-1011

Purpose The term ""theranostics"" represents a new paradigm in medicine especially for cancer treatment. This term was coined by Funkhouser in 2002 and defines a reagent that combines therapeutic and diagnostic properties. It is widely believed that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f040ccce23f07c1b73bea2df750a5aee
https://doi.org/10.1007/s00432-016-2122-7

Zobrazit plný text záznamu

Fine Tuning Antibody Conjugation Methods using SNAP-tag Technology

Autor: Gisela Maria Hanz, Felix Zeppernick, Ivo Meinhold-Heerlein, Elmar Stickeler, Rainer Fischer, Ahmad Fawzi Hussain, Gerrit Gresch, Katharina Kolberg, Andreas Bleilevens, Claudia Kessler, Dirk Bauerschlag, Anka Maria Haugg, Elmar Weinhold, Karinna Chouman, Nicolai Maass, Radoslav Mladenov, Mira Woitok

Publikováno v: Anti-Cancer Agents in Medicinal Chemistry. 17

Background Targeted imaging and therapy (theranostics) is a promising approach for the simultaneous improvement of cancer diagnosis, prognosis and management. Therapeutic and imaging reagents are coupled to tumor-targeting molecules such as antibodie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0b52e387fb30ba5fcccc56ea126e5e
https://doi.org/10.2174/1871520617666170213123737

Zobrazit plný text záznamu

Efficient targeting of CD13 on cancer cells by the immunotoxin scFv13-ETA' and the bispecific scFv [13xds16]

Autor: Rolf Fendel, Mira Woitok, Gerrit Gresch, Stefan Barth, Rainer Fischer, Christoph Stein, Elena Grieger, Judith Niesen

Publikováno v: Journal of cancer research and clinical oncology. 143(11)

Treatment of cancer using standard chemotherapy still offers a poor prognosis combined with severe side effects. Novel antibody-based therapies have been shown to overcome low efficiency and lack of selectivity by targeting cancer-associated antigens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d121e3ce6dfe81f0f0d6f225495c01a4
https://pubmed.ncbi.nlm.nih.gov/28669053

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání