Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mira T. Kassouf"'
Autor:
Andrew J. King, Duantida Songdej, Damien J. Downes, Robert A. Beagrie, Siyu Liu, Megan Buckley, Peng Hua, Maria C. Suciu, A. Marieke Oudelaar, Lars L. P. Hanssen, Danuta Jeziorska, Nigel Roberts, Stephanie J. Carpenter, Helena Francis, Jelena Telenius, Aude-Anais Olijnik, Jacqueline A. Sharpe, Jacqueline Sloane-Stanley, Jennifer Eglinton, Mira T. Kassouf, Stuart H. Orkin, Len A. Pennacchio, James O. J. Davies, Jim R. Hughes, Douglas R. Higgs, Christian Babbs
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Globin loci harbor genes that are expressed embryonically and silenced postnatally. Here the authors show that zeta-globin silencing depends upon selective hypoacetylation of its TAD subdomain, which blocks its interaction with the alpha-globin super
Externí odkaz:
https://doaj.org/article/eb63b89aa9ae4973bb86a64000a9ce01
Autor:
Helena S. Francis, Caroline L. Harold, Robert A. Beagrie, Andrew J. King, Matthew E. Gosden, Joseph W. Blayney, Danuta M. Jeziorska, Christian Babbs, Douglas R. Higgs, Mira T. Kassouf
Publikováno v:
PLoS ONE, Vol 17, Iss 1 (2022)
Mouse embryonic stem cells (mESCs) can be manipulated in vitro to recapitulate the process of erythropoiesis, during which multipotent cells undergo lineage specification, differentiation and maturation to produce erythroid cells. Although useful for
Externí odkaz:
https://doaj.org/article/baa5ea583f194f4d8f3af8a8cc7078c9
Autor:
Jill M. Brown, Nigel A. Roberts, Bryony Graham, Dominic Waithe, Christoffer Lagerholm, Jelena M. Telenius, Sara De Ornellas, A. Marieke Oudelaar, Caroline Scott, Izabela Szczerbal, Christian Babbs, Mira T. Kassouf, Jim R. Hughes, Douglas R. Higgs, Veronica J. Buckle
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Self-interacting chromatin domains encompass genes and their cis-regulatory elements. Here the authors use high-resolution chromosome conformation capture and super-resolution imaging to study a 70 kb domain that includes the mouse α-globin regulato
Externí odkaz:
https://doaj.org/article/330016a401574168bf45d1576eed899f
Autor:
Robert A. Beagrie, M Gosden, Danuta M. Jeziorska, Helena Francis, Christian Babbs, Douglas R. Higgs, Mira T. Kassouf, Andrew King, C L Harrold, Joseph Blayney
Mouse embryonic stem cells (mESCs) can be manipulatedin vitroto recapitulate the process of erythropoiesis, during which multipotent cells undergo lineage specification, differentiation and maturation to produce erythroid cells. Although useful for i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a96ada153d435a54cf92aa6dce6bd412
https://doi.org/10.1101/2020.11.10.376749
https://doi.org/10.1101/2020.11.10.376749
Autor:
Jacqueline A. Sharpe, Megan Buckley, Helena Francis, Jacqueline A. Sloane-Stanley, Siyu Liu, Mira T. Kassouf, Maria C. Suciu, Christian Babbs, Jennifer Eglinton, Stephanie J Carpenter, Stuart H. Orkin, Andrew J. King, Aude-Anais Olijnik, Lars L. P. Hanssen, Danuta M. Jeziorska, Damien J. Downes, Nigel A. Roberts, Jelena Telenius, Robert A. Beagrie, A. Marieke Oudelaar, Peng Hua, Len A. Pennacchio, James O.J. Davies, Duantida Songdej, Douglas R. Higgs, Jim R. Hughes
Publikováno v:
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The α- and β-globin loci harbor developmentally expressed genes, which are silenced throughout post-natal life. Reactivation of these genes may offer therapeutic approaches for the hemoglobinopathies, the most common single gene disorders. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2e55d901b82c1f35bff2076e580a90
https://pubmed.ncbi.nlm.nih.gov/34290235
https://pubmed.ncbi.nlm.nih.gov/34290235
Publikováno v:
Current Opinion in Genetics & Development
Current Opinion in Genetics and Development
Current Opinion in Genetics and Development
The mammalian globin gene clusters provide a paradigm for studying the relationship between genome structure and function. As blood stem cells undergo lineage specification and differentiation to form red blood cells, the chromatin structure and expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9555d1130994515f01d9a58e0b60a3
https://pubmed.ncbi.nlm.nih.gov/33221670
https://pubmed.ncbi.nlm.nih.gov/33221670
Autor:
R Stolper, Jim R. Hughes, Chris Preece, Lars L. P. Hanssen, C L Harrold, Daniel Biggs, Jacqueline A. Sharpe, Doug Higgs, Damien J. Downes, Jelena Telenius, Samy Alghadban, Jacqueline A. Sloane-Stanley, Mira T. Kassouf, Benjamin Davies, M Gosden
Mammalian genomes are subdivided into large (50-2000 kb) regions of chromatin referred to as Topologically Associating Domains (TADs or sub-TADs). Chromatin within an individual TAD contacts itself more frequently than with regions in surrounding TAD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0e4bd42e7a8fa789352e9da59e6b851
https://doi.org/10.1101/2020.07.01.182089
https://doi.org/10.1101/2020.07.01.182089
Autor:
A. Marieke Oudelaar, Jacqueline A. Sharpe, Mira T. Kassouf, Douglas R. Higgs, Lars L. P. Hanssen, Chris Preece, Benjamin Davies, Jacqueline A. Sloane-Stanley, Damien J. Downes, M Gosden, Daniel Biggs, Jim R. Hughes
Publikováno v:
Nature cell biology
The genome is organized via CTCF–cohesin-binding sites, which partition chromosomes into 1–5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-domains (sub-TADs). Here we examined in vivo an ∼80 kb sub-TAD, con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77190927cfb68566f3c6cacb08e19b0e
http://europepmc.org/articles/PMC5540176
http://europepmc.org/articles/PMC5540176
Autor:
A. Marieke Oudelaar, Douglas R. Higgs, Jim R. Hughes, Ross C. Hardison, Mira T. Kassouf, Lars L. P. Hanssen
Publikováno v:
Human Molecular Genetics
It has been known for over a century that chromatin is not randomly distributed within the nucleus. However, the question of how DNA is folded and the influence of such folding on nuclear processes remain topics of intensive current research. A longs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f16d589e8e04e56d2d72c8aa7cd61a7
https://doi.org/10.1093/hmg/ddx306
https://doi.org/10.1093/hmg/ddx306
Autor:
Christoffer Lagerholm, Sara De Ornellas, Nigel A. Roberts, Christian Babbs, Veronica J. Buckle, Bryony Graham, Jelena Telenius, Mira T. Kassouf, Jim R. Hughes, A. Marieke Oudelaar, Jill M. Brown, Douglas R. Higgs, Izabela Szczerbal, Dominic Waithe
A variety of self-interacting domains, defined at different levels of resolution, have been described in mammalian genomes. These include Chromatin Compartments (A and B)1, Topologically Associated Domains (TADs)2,3, contact domains4,5, sub-TADs6, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6189d31e7d6dd6e7ea206943becc58ff