Disposition of two highly permeable drugs in the stomach and the upper small intestine of healthy adults after a standard high-calorie, high-fat meal

Autor: Christina Pentafragka Maria Vertzoni Mira Symillides Konstantinos Goumas Christos Reppas

Objectives: To quantify the presence of two model highly permeable drugs, paracetamol and danazol, in the upper gastrointestinal lumen under conditions simulating the situation after disintegration of immediate release dosage forms administered in bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::5df8c414a87ebcf2067aa7de477b45d9
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2903599

On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants:an Exploratory Study Highlighting the Importance of Infant Food

Autor: Maria Vertzoni, Nikoletta Fotaki, Mira Symillides, Christos Reppas, Marina Statelova, Konstantinos Goumas, René Holm

Publikováno v: Statelova, M, Goumas, K, Fotaki, N, Holm, R, Symillides, M, Reppas, C & Vertzoni, M 2020, ' On the Design of Food Effect Studies in Adults for Extrapolating Oral Drug Absorption Data to Infants : an Exploratory Study Highlighting the Importance of Infant Food ', AAPS Journal, vol. 22, no. 1, 6 . https://doi.org/10.1208/s12248-019-0380-4
The AAPS Journal

In the present investigation, it was explored whether food effect on drug absorption in adults is similar with the food effect after administration of an infant meal with the drug product to adults. After confirming lack of pharmaceutical and pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955e732292b5001cbbcd5b15acdefe33
https://purehost.bath.ac.uk/ws/files/202386757/Paediatric_food_effect_and_meals_adults_AAPS_J.pdf

Evaluation of the Impact of Excipients and an Albendazole Salt on Albendazole Concentrations in Upper Small Intestine Using an In Vitro Biorelevant Gastrointestinal Transfer (BioGIT) System

Autor: James Butler, Mira Symillides, Maria Vertzoni, Ibrahim Khadra, Hugh Clark, Alexandros Kourentas, Gavin Halbert, Christos Reppas

Publikováno v: Journal of Pharmaceutical Sciences. 105:2896-2903

An in vitro biorelevant gastrointestinal transfer (BioGIT) system was assessed for its ability to mimic recently reported albendazole concentrations in human upper small intestine after administration of free base suspensions to fasted adults in abse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2769ea5089f328d7ab304f6abfb08575
https://doi.org/10.1016/j.xphs.2016.04.037

On the design of food effect studies in adults for extrapolating oral drug absorption data to infants: An exploratory study highlighting the importance of infant food

Autor: Marina Statelova, Konstantinos Goumas, Nikoletta Fotaki, René Holm, Mira Symillides, Christos Reppas, Maria Vertzoni

In the present investigation, it was explored whether food effect on drug absorption in adults is similar with the food effect after administration of an infant meal with the drug product to adults. After confirming lack of pharmaceutical and pharmac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::680edfc289ab948e96eeb92dd81ecbb7
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2883653

Two-Stage Single-Compartment Models to Evaluate Dissolution in the Lower Intestine

Autor: Filippos Kesisoglou, Mira Symillides, Maria Vertzoni, Christos Reppas, Constantinos Markopoulos

Publikováno v: Journal of Pharmaceutical Sciences. 104:2986-2997

The purpose was to propose two-stage single-compartment models for evaluating dissolution characteristics in distal ileum and ascending colon, under conditions simulating the bioavailability and bioequivalence studies in fasted and fed state by using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72584b25f462fbca871e779cc8f48716
https://doi.org/10.1002/jps.24485