Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Mira Pochron"'
Autor:
Satheesh Chonat, Earl Fields, Hannah Baratz, Amanda Watt, Mira Pochron, Sandy Dixon, Margaret Tonda, Clark Brown, David Archer
Publikováno v:
eJHaem, Vol 5, Iss 1, Pp 125-130 (2024)
Abstract Introduction: Sickle haemoglobin (HbS) polymerisation perturbs red blood cell (RBC) rheology and drives sickle cell disease (SCD) pathophysiology. Voxelotor is an HbS polymerisation inhibitor that increases haemoglobin (Hb)–oxygen affinity
Externí odkaz:
https://doaj.org/article/d85d9eb3edf449ed8d418c775d96b9ae
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
In sickle cell disease (SCD), higher whole blood viscosity is a risk factor for vaso-occlusive crisis, avascular necrosis, and proliferative retinopathy. Blood viscosity is strongly impacted by hemoglobin (Hb) levels and red blood cell (RBC) deformab
Externí odkaz:
https://doaj.org/article/ddc0d935231c431eab449bccda6c81f2
Autor:
Merin Thomas, Andrew Crouch, Jaime Luis Betancourt, Leena Vattappally, Annie Ngyuen Dang, Sean T Campbell, Mira Pochron, E. Friedman, Julissa Morales, Susanna A Curtis, Caterina P. Minniti
Publikováno v:
Blood. 138:2025-2025
Background: Voxelotor (Oxbryta®) is a small molecule that binds to the alpha chain of hemoglobin (Hb) and increases the affinity of Hb for oxygen which reduces sickle Hb polymerization. It was approved by the FDA in 2019 for the treatment of sickle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e8fe0b26f5017b2eda71d1a5d084a1c
https://doi.org/10.1182/blood-2021-153676
https://doi.org/10.1182/blood-2021-153676
Autor:
Margaret Tonda, Earl Fields, Hannah Baratz, Sandy Dixon, Satheesh Chonat, David R. Archer, Mira Pochron, Clark Brown, Joshua Lehrer-Graiwer, Amanda Watt
Publikováno v:
Blood. 134:2281-2281
Background: Sickle hemoglobin (HbS) under conditions of deoxygenation polymerizes to cause sickling of red blood cells (RBCs) and other rheological abnormalities. Voxelotor has been previously shown in a preclinical model of sickle cell disease (SCD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa41d16ea7bca3584ead90f5ed3040e
https://doi.org/10.1182/blood-2019-129351
https://doi.org/10.1182/blood-2019-129351