Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Mira Krendel"'
Autor:
Angelina Regua, Csaba Papp, Andre Grageda, Baylee A. Porter, Tiffany Caza, Isabelle Bichindaritz, Mira Krendel, Abirami Sivapiragasam, Gennady Bratslavsky, Vladimir A. Kuznetsov, Leszek Kotula
Publikováno v:
Molecular Oncology, Vol 16, Iss 14, Pp 2632-2657 (2022)
Despite the current standard of care, breast cancer remains one of the leading causes of mortality in women worldwide, thus emphasizing the need for better predictive and therapeutic targets. ABI1 is associated with poor survival and an aggressive br
Externí odkaz:
https://doaj.org/article/195f405edb7f4b7589ba1a65f66976c7
Autor:
Daan Vorselen, Sarah R Barger, Yifan Wang, Wei Cai, Julie A Theriot, Nils C Gauthier, Mira Krendel
Publikováno v:
eLife, Vol 10 (2021)
Phagocytosis requires rapid actin reorganization and spatially controlled force generation to ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs membrane extensions to engulf such diverse targets remains unclear
Externí odkaz:
https://doaj.org/article/aef0f4ad09434fbab2364d8bb7e93e64
Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis
Autor:
Sarah R. Barger, Nicholas S. Reilly, Maria S. Shutova, Qingsen Li, Paolo Maiuri, John M. Heddleston, Mark S. Mooseker, Richard A. Flavell, Tatyana Svitkina, Patrick W. Oakes, Mira Krendel, Nils C. Gauthier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Phagocytosis of pathogens is thought to proceed through the sequential engagement of Fc-receptors on the phagocyte with antibodies on the target surface. Here authors show that myosin 1e and myosin 1f link the actin cytoskeleton to the membrane and a
Externí odkaz:
https://doaj.org/article/42adf260ea6c448fbdbf17cfb3eda9f6
Autor:
Jing Bi, Robert T. Carroll, Michael L. James, Jessica L. Ouderkirk, Mira Krendel, Vladimir Sirotkin
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 8, Pp 891-902 (2015)
Point mutations in the human MYO1E gene, encoding class I myosin Myo1e, are associated with focal segmental glomerulosclerosis (FSGS), a primary kidney disorder that leads to end-stage kidney disease. In this study, we used a simple model organism, f
Externí odkaz:
https://doaj.org/article/733d55e1adb941ab9ba2ad66a91f2a28
Autor:
Prabuddha Gupta, Nils C. Gauthier, Yu Cheng-Han, Yuan Zuanning, Bruno Pontes, Malte Ohmstede, René Martin, Hans-Joachim Knölker, Hans-Günther Döbereiner, Mira Krendel, Michael Sheetz
Publikováno v:
Biology Open, Vol 2, Iss 12, Pp 1288-1299 (2013)
Summary Because the actin network in active lamellipodia is continuously assembling at the edge, moving inward and disassembling, there is a question as to how actin-binding proteins and other components are transported to the leading edge and how na
Externí odkaz:
https://doaj.org/article/c4553e7e02cf4a579b58abc3b35031f5
Autor:
Raj Kumar Sadhu, Sarah R. Barger, Samo Penič, Aleš Iglič, Mira Krendel, Nils C. Gauthier, Nir S. Gov
Publikováno v:
Soft Matter. 19:31-43
Phagocytosis is the process of engulfment and internalization of comparatively large particles by cells, and plays a central role in the functioning of our immune system. We study the process of phagocytosis by considering a simplified coarse grained
Autor:
Claire E. Martin, Noah J. Phippen, Ava Keyvani Chahi, Manali Tilak, Sara L. Banerjee, Peihua Lu, Laura A. New, Casey R. Williamson, Mathew J. Platt, Jeremy A. Simpson, Mira Krendel, Nicolas Bisson, Anne-Claude Gingras, Nina Jones
Publikováno v:
Journal of the American Society of Nephrology. 33:1546-1567
Autor:
Mira Krendel, Sabine Leh, Michael E. Garone, Alcia Edwards-Richards, Jen-Jar Lin, Damien Brackman, Per Knappskog, Alexei Mikhailov
Publikováno v:
Pediatric Nephrology. 38:439-449
Pathogenic mutations in the non-muscle single-headed myosin, myosin 1E (Myo1e), are a rare cause of pediatric focal segmental glomerulosclerosis (FSGS). These mutations are biallelic, to date only reported as homozygous variants in consanguineous fam
Autor:
Eric L. Plante, Sharon E. Chase, Ebbing P. de Jong, Theresa M. Curtis, Michael E. Garone, Mira Krendel
Expression of the unconventional myosin, Myosin-1e (Myo1e), has been shown to contribute to tumor progression in the MMTV-PyMT mouse model of mammary tumorigenesis and is associated with poor outcome in breast cancer patients. However, the specific e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::863a0023f89a6b85c152d48c056a9374
https://doi.org/10.1101/2022.04.27.489205
https://doi.org/10.1101/2022.04.27.489205