Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Mira Barda‐Saad"'
Autor:
Guy Biber, Aviad Ben-Shmuel, Elad Noy, Noah Joseph, Abhishek Puthenveetil, Neria Reiss, Omer Levy, Itay Lazar, Ariel Feiglin, Yanay Ofran, Meirav Kedmi, Abraham Avigdor, Sophia Fried, Mira Barda-Saad
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Cancer cells proliferate and invade via cytoskeletal proteins such as WASp, exclusively expressed in hematopoietic cells. Here the authors show a specific small molecule compound inhibiting cancer cell activity by WASp degradation and demonstrating i
Externí odkaz:
https://doaj.org/article/42c120d99789446b99e08ed0d9914e76
Autor:
Aviad Ben-Shmuel, Batel Sabag, Abhishek Puthenveetil, Guy Biber, Moria Levy, Tammir Jubany, Fatima Awwad, Roshan Kumar Roy, Noah Joseph, Omri Matalon, Jessica Kivelevitz, Mira Barda-Saad
Publikováno v:
eLife, Vol 11 (2022)
Natural killer (NK) cells play a crucial role in immunity, killing virally infected and cancerous cells. The balance of signals initiated upon engagement of activating and inhibitory NK receptors with cognate ligands determines killing or tolerance.
Externí odkaz:
https://doaj.org/article/0eb12ba0b3104ee0ad2a469b937d9066
Autor:
Guy Biber, Batel Sabag, Anat Raiff, Aviad Ben‐Shmuel, Abhishek Puthenveetil, Jennifer I C Benichou, Tammir Jubany, Moria Levy, Shiran Killner, Mira Barda‐Saad
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 1, Pp n/a-n/a (2022)
Abstract Natural killer (NK) cells provide a powerful weapon mediating immune defense against viral infections, tumor growth, and metastatic spread. NK cells demonstrate great potential for cancer immunotherapy; they can rapidly and directly kill can
Externí odkaz:
https://doaj.org/article/43754ee220b8461cb4855fa6ba5454c7
Autor:
Batel Sabag, Moria Levy, Jessica Kivelevitz, Nataly Dashevsky, Aviad Ben-Shmuel, Abhishek Puthenveetil, Fatima Awwad, Mira Barda-Saad
Publikováno v:
Cancers, Vol 14, Iss 15, p 3756 (2022)
Understanding the crosstalk between natural killer (NK) cells and the tumor microenvironment (TME) has enhanced the potential of exploiting the interplay between activation and inhibition of NK cells for immunotherapy. This interaction is crucial for
Externí odkaz:
https://doaj.org/article/12cfdf16f14d4870aae03a1fb8f87ad8
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Natural killer (NK) cells are innate lymphoid cells, which play key roles in elimination of virally infected and malignant cells. The balance between activating and inhibitory signals derived from NK surface receptors govern the NK cell immune respon
Externí odkaz:
https://doaj.org/article/3b52d230fcfb4efca6a262bee6467052
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The emergence of immunotherapy for cancer treatment bears considerable clinical promise. Nevertheless, many patients remain unresponsive, acquire resistance, or suffer dose-limiting toxicities. Immune-editing of tumors assists their escape from the i
Externí odkaz:
https://doaj.org/article/cb056f84357a42a7a77edef150bcbc44
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/7b91629456fb4cbc81a0d884db48d534
Autor:
Avishay Edri, Avishai Shemesh, Muhammed Iraqi, Omri Matalon, Michael Brusilovsky, Uzi Hadad, Olga Radinsky, Orly Gershoni-Yahalom, John M. Dye, Ofer Mandelboim, Mira Barda-Saad, Leslie Lobel, Angel Porgador
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The Ebola virus (EBOV) uses evasion mechanisms that directly interfere with host T-cell antiviral responses. By steric shielding of human leukocyte antigen class-1, the Ebola glycoprotein (GP) blocks interaction with T-cell receptors (TCRs), thus ren
Externí odkaz:
https://doaj.org/article/eb7ada3b6b394490ba43790efa5efe92
Autor:
Omri Matalon, Mira Barda-Saad
Publikováno v:
Communicative & Integrative Biology, Vol 9, Iss 6 (2016)
Natural killer (NK) cells are essential for killing transformed and virally infected cells. To prevent auto-reactivity, NK cell activation is inhibited by inhibitory receptors that activate the tyrosine phosphatase SHP-1, which dephosphorylates signa
Externí odkaz:
https://doaj.org/article/e5eda6cd04574efdafb31243a19fcf4f
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 6, Pp 7629-7647 (2012)
Actin polymerization is a fundamental cellular process regulating immune cell functions and the immune response. The Wiskott-Aldrich syndrome protein (WASp) is an actin nucleation promoting factor, which is exclusively expressed in hematopoietic cell
Externí odkaz:
https://doaj.org/article/275790471fe74d86839f75acbc3ae501