Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Miquel Vila-Perelló"'
Autor:
Rob C. Oslund, Tamara Reyes-Robles, Cory H. White, Jake H. Tomlinson, Kelly A. Crotty, Edward P. Bowman, Dan Chang, Vanessa M. Peterson, Lixia Li, Silvia Frutos, Miquel Vila-Perelló, David Vlerick, Karen Cromie, David H. Perlman, Sampat Ingale, Samantha D. O’ Hara, Lee R. Roberts, Grazia Piizzi, Erik C. Hett, Daria J. Hazuda, Olugbeminiyi O. Fadeyi
Publikováno v:
Nature Chemical Biology. 18:850-858
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab69960405338ea714227347b00d561a
https://doi.org/10.1038/s41589-022-01044-0
https://doi.org/10.1038/s41589-022-01044-0
Autor:
Marco Cavaco, Silvia Frutos, David Andreu, Miquel Vila-Perelló, Vera Neves, Paula Oliete, Javier Valle, Miguel A. R. B. Castanho
Publikováno v:
ACS Medicinal Chemistry Letters. 12:1663-1668
© 2021 The Authors. Published by American Chemical Society
The frequency of brain disease has increased significantly in the past years. After diagnosis, therapeutic options are usually limited, which demands the development of innovative thera
The frequency of brain disease has increased significantly in the past years. After diagnosis, therapeutic options are usually limited, which demands the development of innovative thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb762c6d7b427170570f27f6f238f96
https://doi.org/10.1021/acsmedchemlett.1c00225
https://doi.org/10.1021/acsmedchemlett.1c00225
Autor:
Grazia Piizzi, Karen Cromie, Samantha D. O’Hara, Rob C. Oslund, Kelly A. Crotty, Vanessa M. Peterson, Lee R. Roberts, Daria J. Hazuda, Cory H. White, Erik C. Hett, Tamara Reyes-Robles, David H. Perlman, Dan Chang, David Vlerick, Silvia Frutos, Olugbeminiyi O. Fadeyi, Edward P. Bowman, Jake H. Tomlinson, Miquel Vila-Perelló, Lixia Li
Cell-cell interactions drive essential biological processes critical to cell and tissue development, function, pathology, and disease outcome. The growing appreciation of immune cell interactions within disease environments has led to significant eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be94bbf6f8e3c3e1350c37ea44680a31
https://doi.org/10.1101/2021.10.04.463039
https://doi.org/10.1101/2021.10.04.463039
Publikováno v:
Organic & Biomolecular Chemistry. 14:9549-9553
An ideal drug should be highly effective, non-toxic and be delivered by a convenient and painless single dose. We are still far from such optimal treatment but peptides, with their high target selectivity and low toxicity profiles, provide a very att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15599b68a1798f462651c740963fffa0
https://doi.org/10.1039/c6ob01833e
https://doi.org/10.1039/c6ob01833e
Autor:
Carme Calvis, Silvia Frutos, Jaume Adan, Anabel Otero, José L. Hernández, Francesc Mitjans, Miquel Vila-Perelló
Publikováno v:
Bioconjugate chemistry. 29(11)
Antibody-Drug Conjugates (ADCs) have been shown to produce clinical benefit in cancer patient thanks to their ability to target highly cytotoxic small molecules to tumor cells. However, the development of these complex molecules faces significant cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9578e166286295f98845f233e7cf4f2
https://pubmed.ncbi.nlm.nih.gov/30346741
https://pubmed.ncbi.nlm.nih.gov/30346741
Autor:
Galia T. Debelouchina, Matthew J. Bick, Miquel Vila-Perelló, Zhihua Liu, Seth A. Darst, Silvia Frutos, Tom W. Muir
Publikováno v:
Proceedings of the National Academy of Sciences. 111:8422-8427
Inteins are autoprocessing domains that cut themselves out of host proteins in a traceless manner. This process, known as protein splicing, involves multiple chemical steps that must be coordinated to ensure fidelity in the process. The committed ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc057c2150a4d6da164480d0f36b8d35
https://doi.org/10.1073/pnas.1402942111
https://doi.org/10.1073/pnas.1402942111
Autor:
Miquel Vila-Perelló, Scott Barbuto, Juliana Idoyaga, Ralph M. Steinman, Maria Paula Longhi, Gaëlle Breton, Tom W. Muir
Publikováno v:
Nature Chemical Biology. 9:250-256
Targeted delivery of antigens to dendritic cells (DCs) is a promising vaccination strategy. However, to ensure immunity, the approach depends on coadministration of an adjuvant. Here we ask whether targeting of both adjuvant and antigen to DCs is suf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2619e83bf7f6466466aebdfc5a3536
https://doi.org/10.1038/nchembio.1186
https://doi.org/10.1038/nchembio.1186
Publikováno v:
Journal of the American Chemical Society
Chemically modified proteins are invaluable tools for studying the molecular details of biological processes, and they also hold great potential as new therapeutic agents. Several methods have been developed for the site-specific modification of prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54a1c743e88055fa8409061ecdf9e77
https://doi.org/10.1021/ja309126m
https://doi.org/10.1021/ja309126m
Publikováno v:
Angewandte Chemie International Edition. 50:6511-6515
Coulombic forces play an important role in facilitating protein–protein interactions. It has been demonstrated that a strong electrostatic potential between two interacting proteins correlates with a fast rate of association and a strong binding af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed6bbde33ff0dc3b416cfd62aabf014
https://doi.org/10.1002/anie.201102909
https://doi.org/10.1002/anie.201102909
Autor:
Daniel P. Raleigh, Vasant Muralidharan, Miquel Vila-Perelló, Arthur G. Palmer, Tom W. Muir, Jae-Hyun Cho
Publikováno v:
Nature structural & molecular biology
Activation of many multidomain signaling proteins requires rearrangement of autoinhibitory interdomain interactions that occlude activator binding sites. In one model for activation, the major inactive conformation exists in equilibrium with activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f66a121bd111cd238c686d71a9dd9d
https://doi.org/10.1038/nsmb.2039
https://doi.org/10.1038/nsmb.2039