Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

Autor: Groelly, FJ, Dagg, RA, Petropoulos, M, Rossetti, GG, Prasad, B, Panagopoulos, A, Paulsen, T, Karamichali, A, Jones, SE, Ochs, F, Dionellis, VS, Puig Lombardi, E, Miossec, MJ, Lockstone, H, Legube, G, Blackford, AN, Altmeyer, M, Halazonetis, TD, Tarsounas, M

Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we identify genome-wide the sites where MiDAS reactions occur when BRCA2 is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93efe3e828f6bf5a0f5a0e7f4f33f891
https://ora.ox.ac.uk/objects/uuid:98c91cf1-6c91-4808-a671-a9b09cb6c0ec

Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.

Autor: Groelly FJ; Genome Stability and Tumourigenesis Group, Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK., Dagg RA; Genome Stability and Tumourigenesis Group, Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK., Petropoulos M; Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland., Rossetti GG; Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland., Prasad B; Genome Stability and Tumourigenesis Group, Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK., Panagopoulos A; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland., Paulsen T; Genome Stability and Tumourigenesis Group, Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK., Karamichali A; Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland., Jones SE; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Ochs F; Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK., Dionellis VS; Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland., Puig Lombardi E; Genome Stability and Tumourigenesis Group, Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK., Miossec MJ; Bioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Lockstone H; Bioinformatics and Statistical Genetics Core, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK., Legube G; LBCMCP, Centre de Biologie Intégrative (CBI), CNRS, Université de Toulouse, UT3, Toulouse 31062, France., Blackford AN; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK., Altmeyer M; Department of Molecular Mechanisms of Disease, University of Zurich, 8057 Zurich, Switzerland., Halazonetis TD; Department of Molecular Biology, University of Geneva, 1205 Geneva, Switzerland. Electronic address: thanos.halazonetis@unige.ch., Tarsounas M; Genome Stability and Tumourigenesis Group, Department of Oncology, Oxford Institute for Radiation Oncology, University of Oxford, Oxford OX3 7DQ, UK. Electronic address: madalena.tarsounas@oncology.ox.ac.uk.

Publikováno v: Molecular cell [Mol Cell] 2022 Sep 15; Vol. 82 (18), pp. 3382-3397.e7. Date of Electronic Publication: 2022 Aug 23.

Integration of target discovery, drug discovery and drug delivery: A review on computational strategies.

Autor: Duarte Y; Center for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile., Márquez-Miranda V; Center for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile., Miossec MJ; Center for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile., González-Nilo F; Center for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.; Centro Interdisciplinario de Neurociencias de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

Publikováno v: Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology [Wiley Interdiscip Rev Nanomed Nanobiotechnol] 2019 Jul; Vol. 11 (4), pp. e1554. Date of Electronic Publication: 2019 Apr 01.

Whole Exome Sequencing Reveals the Major Genetic Contributors to Nonsyndromic Tetralogy of Fallot.

Autor: Page DJ; From the Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom (D.J.P., S.G.W., R.M.M., E.F., B.D.K.)., Miossec MJ; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (M.J.M., H.J.C., L.S., A.T., M.S.-K.).; Center for Bioinformatics and Integrative Biology, Faculty of Biological Sciences, Universidad Andrés Bello, Santiago, Chile (M.J.M.)., Williams SG; From the Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom (D.J.P., S.G.W., R.M.M., E.F., B.D.K.)., Monaghan RM; From the Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom (D.J.P., S.G.W., R.M.M., E.F., B.D.K.)., Fotiou E; From the Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom (D.J.P., S.G.W., R.M.M., E.F., B.D.K.)., Cordell HJ; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (M.J.M., H.J.C., L.S., A.T., M.S.-K.)., Sutcliffe L, Topf A; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (M.J.M., H.J.C., L.S., A.T., M.S.-K.)., Bourgey M; Canadian Centre for Computational Genomics, Montréal, QC, Canada (M.B.).; McGill Genome Center, Montréal, QC, Canada (M.B., G.B., R.E., G.M.L.)., Bourque G; McGill Genome Center, Montréal, QC, Canada (M.B., G.B., R.E., G.M.L.)., Eveleigh R; McGill Genome Center, Montréal, QC, Canada (M.B., G.B., R.E., G.M.L.)., Dunwoodie SL; Chain Reaction Program in Congenital Heart Disease Research, Victor Chang Cardiac Research Institute, Sydney, NSW, Australia (S.L.D.).; Faculties of Medicine and Science, University of New South Wales, Sydney (S.L.D.).; Heart Centre for Children, The Children's Hospital at Westmead, Sydney, NSW (S.L.D.)., Winlaw DS; School of Child and Adolescent Health, Sydney Medical School, University of Sydney (D.S.W.).; Victor Chang Cardiac Research Institute, NSW, Australia (D.S.W.).; RDM Cardiovascular Medicine, Wellcome Centre for Human Genetics, University of Oxford (D.S.W., S.B.)., Bhattacharya S; RDM Cardiovascular Medicine, Wellcome Centre for Human Genetics, University of Oxford (D.S.W., S.B.).; Center for Human Genetics, Catholic University Leuven, Belgium (S.B., J.B., K.D.)., Breckpot J; Center for Human Genetics, Catholic University Leuven, Belgium (S.B., J.B., K.D.).; Pediatric and Congenital Cardiology, UZ Leuven (J.B., M.G.)., Devriendt K; Center for Human Genetics, Catholic University Leuven, Belgium (S.B., J.B., K.D.)., Gewillig M; Pediatric and Congenital Cardiology, UZ Leuven (J.B., M.G.)., Brook JD; School of Life Sciences, University of Nottingham, Queen's Medical Centre (J.D.B., K.J.S.)., Setchfield KJ; School of Life Sciences, University of Nottingham, Queen's Medical Centre (J.D.B., K.J.S.)., Bu'Lock FA; Congenital and Paediatric Cardiology, East Midlands Congenital Heart Centre and University of Leicester, Glenfield Hospital (F.A.B.)., O'Sullivan J; Adult Congenital and Paediatric Cardiac Unit, Freeman Hospital, Newcastle upon Tyne (J.O.)., Stuart G; University Hospitals Bristol NHS Foundation Trust, Bristol (G.S.)., Bezzina CR; Heart Center, Department of Clinical and Experimental Cardiology (C.R.B.), Academic Medical Center, Amsterdam, the Netherlands., Mulder BJM; Department of Medical Biology (B.J.M.M.), Academic Medical Center, Amsterdam, the Netherlands., Postma AV; Department of Clinical Genetics (A.V.P.), Academic Medical Center, Amsterdam, the Netherlands., Bentham JR; Department of Paediatric Cardiology, Yorkshire Heart Centre, Leeds (J.R.B.)., Baron M; Division of Molecular and Cellular Function, School of Biological Sciences, Faculty of Biology Medicine and Health, University of Manchester (M.B.)., Bhaskar SS; Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Oxford, Manchester (S.S.B., G.C.B.)., Black GC; Manchester Centre for Genomic Medicine, Saint Mary's Hospital, Oxford, Manchester (S.S.B., G.C.B.)., Newman WG; Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Oxford (W.G.N.); and Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, UK., Hentges KE, Lathrop GM; McGill Genome Center, Montréal, QC, Canada (M.B., G.B., R.E., G.M.L.)., Santibanez-Koref M; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom (M.J.M., H.J.C., L.S., A.T., M.S.-K.)., Keavney BD; From the Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine, and Health, Manchester Academic Health Science Centre, University of Manchester, United Kingdom (D.J.P., S.G.W., R.M.M., E.F., B.D.K.).

Publikováno v: Circulation research [Circ Res] 2019 Feb 15; Vol. 124 (4), pp. 553-563.

Computational Methods for Human Microbiome Analysis.

Autor: Miossec MJ; Center for Bioinformatics and Integrative Biology, Faculty of Biological Sciences, Universidad Andrés Bello, Santiago, Chile., Valenzuela SL; Center for Bioinformatics and Integrative Biology, Faculty of Biological Sciences, Universidad Andrés Bello, Santiago, Chile., Mendez KN; Center for Bioinformatics and Integrative Biology, Faculty of Biological Sciences, Universidad Andrés Bello, Santiago, Chile., Castro-Nallar E; Center for Bioinformatics and Integrative Biology, Faculty of Biological Sciences, Universidad Andrés Bello, Santiago, Chile.

Publikováno v: Current protocols in microbiology [Curr Protoc Microbiol] 2017 Nov 09; Vol. 47, pp. 1E.14.1-1E.14.17. Date of Electronic Publication: 2017 Nov 09.