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DOCK2 Deficiency Causes Defects in Antiviral T-Cell Responses and Impaired Control of Herpes Simplex Virus Infection.

Autor: Randall KL; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.; School of Medicine and Psychology, The Australian National University, Canberra, ACT, Australia., Flesch IEA; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Mei Y; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Miosge LA; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Aye R; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Yu Z; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Domaschenz H; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Hollett NA; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Russell TA; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Stefanovic T; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Wong YC; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Seneviratne S; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Ballard F; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Hernandez Gallardo R; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Croft SN; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Goodnow CC; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.; Garvan Institute of Medical Research, University of New South Wales, Darlinghurst, NSW, Australia., Bertram EM; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Enders A; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Tscharke DC; Division of Immunology and Infectious Diseases, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2024 Sep 23; Vol. 230 (3), pp. e712-e721.

Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome.

Autor: Mathur A; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Kay C; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Xue Y; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Pandey A; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Lee J; Centre for Advanced Microscopy, The Australian National University, Canberra, ACT, Australia., Jing W; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Enosi Tuipulotu D; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Lo Pilato J; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Feng S; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Ngo C; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Zhao A; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Shen C; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Rug M; Centre for Advanced Microscopy, The Australian National University, Canberra, ACT, Australia., Miosge LA; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Atmosukarto II; Lipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Price JD; Lipotek Pty Ltd. The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia., Ali SA; Division of Genome Science and Cancer, The Australian National University, Canberra, ACT, Australia., Gardiner EE; Division of Genome Science and Cancer, The Australian National University, Canberra, ACT, Australia., Robertson AA; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, Australia., Awad MM; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, Australia., Lyras D; Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, VIC, Australia., Kaakoush NO; School of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia., Man SM; Division of Immunology and Infectious Disease, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.

Publikováno v: EMBO reports [EMBO Rep] 2023 Jun 05; Vol. 24 (6), pp. e54600. Date of Electronic Publication: 2023 Apr 19.

SATB1 ensures appropriate transcriptional programs within naïve CD8 ⁺ T cells.

Autor: Nüssing S; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia., Miosge LA; John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Lee K; Department of Microbiology, Immunity Theme, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Olshansky M; Department of Microbiology, Immunity Theme, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Barugahare A; Bioinformatics Platform, Monash University, Clayton, VIC, Australia., Roots CM; John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Sontani Y; John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia., Day EB; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia., Koutsakos M; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia., Kedzierska K; Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC, Australia., Goodnow CC; John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; Garvan Institute of Medical Research & Cellular Genomics Futures Institute, University of New South Wales, Darlinghurst, NSW, Australia., Russ BE; Department of Microbiology, Immunity Theme, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Daley SR; John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia.; Centre for Immunology and Infection Control, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, QLD, Australia., Turner SJ; Department of Microbiology, Immunity Theme, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Publikováno v: Immunology and cell biology [Immunol Cell Biol] 2022 Sep; Vol. 100 (8), pp. 636-652. Date of Electronic Publication: 2022 Jul 13.

TLR7 gain-of-function genetic variation causes human lupus.

Autor: Brown GJ; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Cañete PF; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Wang H; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Medhavy A; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Bones J; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia., Roco JA; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., He Y; China Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, Shanghai, China., Qin Y; China Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, Shanghai, China., Cappello J; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Ellyard JI; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Bassett K; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Shen Q; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Burgio G; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Zhang Y; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Turnbull C; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Meng X; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Wu P; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Cho E; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Miosge LA; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Andrews TD; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Field MA; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia.; Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Queensland, Australia., Tvorogov D; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia., Lopez AF; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia., Babon JJ; Division of Structural Biology, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., López CA; Sección de Nefrología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Gónzalez-Murillo Á; Unidad de Terapias Avanzadas, Oncología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.; Fundación de Investigación Biomédica, Hospital Infantil Universitario Niño Jesús, Madrid, Spain., Garulo DC; Unidad de Reumatología, Hospital del Niño Jesus, Madrid, Spain., Pascual V; Department of Pediatrics, Drukier Institute for Children's Health, Weill Cornell Medical College, New York, NY, USA., Levy T; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Mallack EJ; Division of Child Neurology, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY, USA., Calame DG; Division of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Lotze T; Division of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.; Texas Children's Hospital, Houston, TX, USA., Lupski JR; Texas Children's Hospital, Houston, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Ding H; China Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, Shanghai, China.; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai, Jiao Tong University (SJTUSM), Shanghai, China., Ullah TR; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Victoria, Australia., Walters GD; Department of Renal Medicine, The Canberra Hospital, Canberra, Australian Capital Territory, Australia., Koina ME; Department of Anatomical Pathology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia., Cook MC; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Shen N; China Australia Centre for Personalised Immunology, Shanghai Renji Hospital, Shanghai Jiaotong University, Shanghai, China.; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai, Jiao Tong University (SJTUSM), Shanghai, China.; Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., de Lucas Collantes C; Sección de Nefrología, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.; Departamento de Pediatría. Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Madrid, Spain., Corry B; Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia., Gantier MP; Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai, Jiao Tong University (SJTUSM), Shanghai, China.; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia., Athanasopoulos V; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia., Vinuesa CG; Centre for Personalised Immunology, Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory, Australia. carola.vinuesa@crick.ac.uk.; Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, South Australia, Australia. carola.vinuesa@crick.ac.uk.; Francis Crick Institute, London, UK. carola.vinuesa@crick.ac.uk.

Publikováno v: Nature [Nature] 2022 May; Vol. 605 (7909), pp. 349-356. Date of Electronic Publication: 2022 Apr 27.