Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Miook Cho"'
Autor:
Jie Cheng, Miook Cho, Jin-ming Cen, Meng-yun Cai, Shun Xu, Ze-wei Ma, Xinguang Liu, Xi-li Yang, Can Chen, Yousin Suh, Xing-dong Xiong
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115339 (2015)
SIRT1 exerts protective effects against endothelial cells dysfunction, inflammation and atherosclerosis, indicating an important role on myocardial infarction (MI) pathogenesis. Nonetheless, the effects of SIRT1 variants on MI risk remain poorly unde
Externí odkaz:
https://doaj.org/article/01b378ca709a454584b931abb24fce56
Autor:
Samuel J. Wattrus, Miook Cho, Austin Valido, Amy J. Wagers, Kathleen A. Messemer, Paul Besseling, Richard T. Lee, Ryan G. Walker, Melanie J. Mills, Jill M. Goldstein, Kyu Ha Lee, Jordan P. Lewandowski
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports
Scientific Reports
Recent advances in CRISPR/Cas gene editing technology have significantly expanded the possibilities and accelerated the pace of creating genetically engineered animal models. However, CRISPR/Cas-based strategies designed to precisely edit the genome
Autor:
Magdalena Czepnik, Jason C. McCoy, Erich J Goebel, Kelly L. Walton, Miook Cho, Craig A. Harrison, Gauthier Schang, Amy J. Wagers, Erik Martinez-Hackert, Ryan G. Walker, Daniel J. Bernard, Andrew P. Hinck, Senem Aykul, Juhyun Oh, Thomas B. Thompson, Ana Vujic, Richard T. Lee
Publikováno v:
BMC Biology
Background Growth/differentiation factor 8 (GDF8) and GDF11 are two highly similar members of the transforming growth factor β (TGFβ) family. While GDF8 has been recognized as a negative regulator of muscle growth and differentiation, there are con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1297a842fc51892500d150836c2c8b13
Autor:
Miook Cho, Juewon Kim, Jee-Young Lee, Yousin Suh, Shin-Hae Lee, Kyung Jin Min, Hye-Yeon Lee, Si-Young Cho, Dong-Hwa Choi
Publikováno v:
Advanced biosystems. 4(7)
Many studies utilizing animal models have revealed the genetic and pharmacogenetic modulators of the rate of organismal aging. However, finding routes for healthy aging during extended life remains one of the largest questions. With regards to an ant
Publikováno v:
Oncotarget
// Siyoung Cho 1 , Miook Cho 2 , Juewon Kim 1 , Matt Kaeberlein 3 , Sang Jun Lee 1 and Yousin Suh 2,4,5 1 R&D Unit, Amorepacific Corporation, Yongin-si, Gyeonggi-do, Korea 2 Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA
Publikováno v:
Aging (Albany NY)
Increased SIRT1 expression exerts beneficial effects in transgenic animal models, ameliorating the onset and progression of aging-related disease phenotypes in various organs including the heart. The potential beneficial effects of SIRT1 have made SI
Autor:
Miook Cho, Yousin Suh
Human genetics has provided a framework for understanding the biology of the human species and is a rapidly growing field of aging research. The genetic analysis of human aging is aimed at identifying genetic variants that reflect the biological age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5510d0649d160e89c991b79c762c6b5
https://doi.org/10.1016/b978-0-12-411596-5.00012-5
https://doi.org/10.1016/b978-0-12-411596-5.00012-5
Autor:
Rolf Bodmer, Rochelle Buffenstein, Hao Cheng, Ying-Ann Chiao, Miook Cho, Eileen M. Crimmins, Dao-Fu Dai, João Pedro de Magalhães, James F. Fries, William Giblin, Vera Gorbunova, Jing-Dong J Han, David E. Harrison, Ingrid A. Harten, Lei Hou, F. Brad Johnson, Matt R. Kaeberlein, Brian K. Kennedy, Ron Korstanje, Edward G. Lakatta, Scott F. Leiser, Morgan E. Levine, Kaitlyn N. Lewis, David B. Lombard, Hillary A. Miller, Richard A. Miller, Robert E. Monticone, Shannon J. Moore, Ludmila Müller, Geoffrey G. Murphy, Nancy L. Nadon, Monique N. O’Leary, Michelle Olive, Graham Pawelec, Scott D. Pletcher, Peter S. Rabinovitch, Katherine H. Schreiber, Andrei Seluanov, Shufei Song, Randy Strong, Yousin Suh, George L. Sutphin, Hazel H. Szeto, Robi Tacutu, Michael Van Meter, Dan Wang, Mingyi Wang, Michael J. Waterson, Robert J. Wessells, Thomas N. Wight, Bo Xian, Ting-Lin B. Yang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::098dc2eb0fb4119b70ce5e826d9ef5cd
https://doi.org/10.1016/b978-0-12-411596-5.00028-9
https://doi.org/10.1016/b978-0-12-411596-5.00028-9
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. :376-383
Age is a major risk factor for many human diseases. Extremely long-lived individuals, such as centenarians, have managed to ward off age-related diseases and serve as human models to search for the genetic factors that influence longevity. The discov
Autor:
Diddahally R. Govindaraju, Temuri Budagov, Gil Atzmon, Aviv Bergman, Clyde B. Schechter, Micol Katz, Woodring E. Wright, Derek M. Huffman, Glenn Siegel, Miook Cho, Nir Barzilai, Yousin Suh, Xiaoman Yang, Richard M. Cawthon, Jerry W. Shay
Publikováno v:
Proceedings of the National Academy of Sciences. 107:1710-1717
Telomere length in humans is emerging as a biomarker of aging because its shortening is associated with aging-related diseases and early mortality. However, genetic mechanisms responsible for these associations are not known. Here, in a cohort of Ash