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pro vyhledávání: '"Mioka Miyamoto"'
Publikováno v:
Journal of Pharmacy and Pharmacology. 71:167-175
Objectives We had previously found that reduced folate carrier (RFC; SLC19A1) is mainly involved in an influx of transport of methotrexate (MTX), a folate analogue, using alveolar epithelial A549 cells. Therefore, we examined MTX uptake in NCl-H441 (
Autor:
Mikihisa Takano, Ryoko Yumoto, Risako Harada, Mioka Miyamoto, Rika Harabayashi, Masashi Kawami
Publikováno v:
Lung. 194:923-930
Methotrexate (MTX) therapy of certain cancers and rheumatoid arthritis often induces serious interstitial lung complications including pulmonary fibrosis. In this study, we investigated the epithelial–mesenchymal transition (EMT) induced by MTX and
Publikováno v:
Drug Metabolism and Pharmacokinetics. 30:276-281
Methotrexate (MTX), a drug used for the treatment of certain cancers as well as rheumatoid arthritis, sometimes induces serious interstitial lung injury. Although lung toxicity of MTX is related to its accumulation, the information concerning MTX tra